Fibrosarcoma of the Soft Parts

Warren, Shields; Sommer, George N.J.

doi:10.1001/archsurg.1936.01190030078004

Cited by 91 publications

(3 citation statements)

References 3 publications

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“…Breast cancer and sarcoma. The first case report of MPNMs including breast cancer and sarcoma was reported in 1936 (66). Another five case reports of these MPNMs have been presented in the literature (34, 67-70).…”

Section: Review Of the Literaturementioning

confidence: 99%

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Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

Luca

Frusone

Vergine

et al. 2019

In Vivo

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Multiple primary malignant neoplasms are multiple tumors with different pathogenetic origin. They may be synchronous or metachronous. The management of these conditions represents an interesting clinical scenario. A crucial aspect is the decision regarding which tumor to treat initially, and how to schedule further treatments according to individual tumor risk. This process involves a multidisciplinary physician team to ensure favorable outcomes. We describe a case report of a female patient affected by primary synchronous tumors of the breast and pectoral skin, which raised a series of diagnostic, etiological and therapeutic issues persuading us to carry out a critical review of the literature. Multiple primary malignant neoplasms (MPMNs), or multiple primary cancers, are defined as multiple tumors with different pathogenetic origin. The phenomenon of MPMN was first described by Billroth at the end of the 19th century (1) and since then several cases of double or even triple primary malignant neoplasms have been reported (1-3). Neoplasms can be synchronous or metachronous and may appear in a single organ or in multiple organs concurrently. According to Moertel (2), synchronous neoplasms are defined as those that occur within 6 months from the diagnosis of a previous malignant tumor, and metachronous neoplasms are defined as neoplasms that appear 6 months after the first diagnosed tumor (2). Despite many changes in the definition have been proposed, the diagnosis of MPMNs that is widely accepted is based on the criteria described by Warren and Gates (3). These criteria require that: (i) each tumor must have a clear picture and histological confirmation of malignancy; (ii) each tumor must be topographically distinct and separated by healthy mucosa (at least 2 cm of normal mucosa between two tumors of the same region); (iii) the lesions must be not metastases of each other (3). In this report, we describe our recent observation and treatment of a female patient affected by primary synchronous tumors of the breast and pectoral skin. This combination, to the best of our knowledge, has never been previously reported in the literature, and it raised a series of diagnostic, etiological and therapeutic issues persuading us to carry out a critical review of the literature.

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Section: Review Of the Literaturementioning

confidence: 99%

“…Another five case reports of these MPNMs have been presented in the literature (34, 67-70). It was Warren who first highlighted how radiotherapy treatment for breast cancer was a risk factor for the development of sarcoma (66).…”

Section: Review Of the Literaturementioning

confidence: 99%

Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

Luca

Frusone

Vergine

et al. 2019

In Vivo

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“…RIA was first reported in the literature in 1929 [6], and the first case of sarcoma after radiotherapy for breast cancer was reported by Warren and Sommer in 1936 [7]. The diagnostic criteria for RIA include a previous history of radiotherapy with a latency period of several years (five or more), development of sarcoma within a previous irradiated field, and a histology confirmation.…”

Section: Discussionmentioning

confidence: 99%

ecancermedicalscience

Aljarrah

Nos

Clough

et al.

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Radiation-induced angiosarcomas (RIA) are rare tumours that can affect breast cancer patients following treatment with breast conservative surgery and radiotherapy. Their diagnosis is often delayed because of their benign appearance and the difficulty in differentiation from radiation-induced skin changes. We report here a case of RIA which occurred seven years after radiotherapy to highlight awareness of the disease and the role of careful histological evaluation of these tumours.

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Dermatofibrosarcoma Protuberans

Binkley¹

1939

Arch Derm Syphilol

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Fibrosarcoma of the Soft Parts

Cited by 91 publications

References 3 publications

Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

ecancermedicalscience

Dermatofibrosarcoma Protuberans

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