Fibrosarcoma of nose and paranasal sinuses

Agarwal, Mudit; Gupta, Sunil; Gupta, Omesh P.; Samant, H. C.

doi:10.1002/jso.2930150109

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…[1][2][3][4]7,9,15,18,[23][24][25][26][27]29 Sinonasal FSs have been previously described in several series and in numerous case reports. [1][2][3][4]17,[23][24][25][26][27] Our understanding of tumors previously classified as FSs has evolved over the past several decades, as immunohistochemistry and molecular studies have led to more precise classification of these tumors as other specific entities. We have recently encountered a distinct sinonasal spindle cell neoplasm with reproducible clinical and pathologic features, previously diagnosed as FS in most instances.…”

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confidence: 99%

Low-grade Sinonasal Sarcoma With Neural and Myogenic Features

Lewis¹,

Oliveira²,

Nascimento

et al. 2012

American Journal of Surgical Pathology

135

196

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Sarcomas of the sinonasal region are rare. We describe a distinct spindle cell sarcoma of the sinonasal region characterized by concomitant neural and myogenic differentiation. Consultation files and surgical cases from Mayo Clinic were reviewed. Twenty-eight cases were identified that met the inclusion criteria. Clinical data were collected from medical records, consultation letters, and referring pathologists. Reverse transcriptase-polymerase chain reaction for synovial sarcoma fusion transcripts was performed on 18 cases. Cytogenetic studies were performed on 2 cases. The 21 female and 7 male patients ranged in age from 24 to 85 years (mean, 52 y). All cases showed a characteristic histology, which included a cellular spindle cell neoplasm with uniform, elongate nuclei and an infiltrative growth pattern. All tumors demonstrated expression of S-100 with actin positivity in 96% of cases tested. Reverse transcriptase-polymerase chain reaction for synovial sarcoma fusion transcripts was negative in all cases tested. Cytogenetic studies conducted on 2 cases demonstrated the chromosomal translocation t(2;4). The nasal cavity (54%) and ethmoid sinus (57%) were the most commonly involved areas, singly or in combination. Follow-up information was available for 57% (16/28) of cases, with a mean of 8.3 years. Of these, 44% (7/16) experienced at least 1 recurrence. No patient has developed metastases or died of disease. We describe a unique tumor with a characteristic morphologic, immunophenotypic, and cytogenetic profile. On the basis of the locally aggressive nature of this lesion we believe it is best considered a low-grade sarcoma and suggest the term low-grade sinonasal sarcoma with neural and myogenic features.

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mentioning

confidence: 99%

Low-grade Sinonasal Sarcoma With Neural and Myogenic Features

Lewis¹,

Oliveira²,

Nascimento

et al. 2012

American Journal of Surgical Pathology

135

196

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“…There was no evidence of recurrence over a two-year follow-up period. A further case involving, but possibly not arising from, the ethmoids was reported by Agarwal et al (1980) where local excision was followed by 500 Gy of post-operative radiotherapy over five weeks. There was no evidence of recurrence three years later.…”

Section: Discussionmentioning

confidence: 99%

Fibrosarcoma of the ethmoid

Smith

Soames

1989

J. Laryngol. Otol.

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Fibrosarcoma may involve the ethmoid sinus by extension from the maxillary antrum or, more rarely arise as a primary neoplasm.A case of a well differentiated primary fibrosarcoma of the ethmoid sinuses is reported which presented in a 24-year-old male. The tumour was treated by wide local resection. From a review of similar cases in the literature together with their treatment modalities and outcome. It is concluded that wide local resection is the treatment of choice.

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“…There was no improvement after palliative radiotherapy and the patient died 3 weeks after admission Died 3 weeks after admission Agarwal et al [13] The patient received radiotherapy Surgical summary: using a Caldwell-Luc approach, resection of the tumor was done…”

Section: No Surgical Intervention Was Donementioning

confidence: 99%

Fibrosarcomas of the Paranasal Sinuses: A Systematic Review

Bughrara¹,

Almsaddi²,

John³

et al. 2022

Cureus

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Fibrosarcomas are rare, malignant neoplasms of mesenchymal origin. Fibrosarcomas appear to be sporadic, but cases of fibrosarcomas secondary to radiation of nasopharyngeal carcinomas have been reported. Paranasal sinus fibrosarcomas (PNFS) are even rarer with few cases being reported since the 1950s. There have been several retrospective cohort studies examining PNFS; however, to our knowledge, no comprehensive review exists. This review aims to summarize the findings of all published cases of PNFS from the 1950s to the 2020s. We hope that a comprehensive review will assist in accurate and early diagnoses of PNFS, and help guide treatment as early treatment is associated with a favorable prognosis. This systematic review reports results following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search was conducted on PubMed, Embase, and Cochrane Library. Studies were screened using established inclusion/exclusion criteria. A total of 26 studies were included for data extraction, and relevant data were collected and analyzed. In our study, the most common study type was case reports (n = 19). The most common presentation for PNFS included male gender (n = 17) with maxillary sinus (n = 57) involvement. Patients commonly presented with complaints of nasal obstruction (n = 15), epistaxis (n = 11), and facial fullness/pain (n = 9). Surgical resection was the mainstay treatment, with the use of chemotherapy or radiation depending on surgical margins and resectability. The diagnosis was commonly made with histological analysis. This review of the literature provides a summary and reference of important presenting factors, elements of diagnosis, and treatment options regarding PNFS to help bring awareness and guide the treatment of such a rare disease. Moving forward, there is a greater need for larger standardized studies that can further complement our findings, as well as more consistent reporting of cases.

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Fibrosarcoma of nose and paranasal sinuses

Cited by 7 publications

References 7 publications

Low-grade Sinonasal Sarcoma With Neural and Myogenic Features

Low-grade Sinonasal Sarcoma With Neural and Myogenic Features

Fibrosarcoma of the ethmoid

Fibrosarcomas of the Paranasal Sinuses: A Systematic Review

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