Fibrosarcoma Associated with a Benign Cystic Teratoma of the Ovary

Krüger, Stefan; Schmidt, Hannelore; Küpker, W.; Rath, Friedrich W.; Feller, Alfred C.

doi:10.1006/gyno.2001.6408

Cited by 22 publications

(9 citation statements)

References 28 publications

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“…Foci of hemorrhage and necrosis within the malignant component are common. The most common secondary tumor is squamous cell carcinoma, corresponding to up to 80% of such neoplasms, but several malignancies have already been reported, including adenocarcinomas, adenosquamous carcinomas, undifferentiated carcinomas, sarcomas, carcinosarcomas, and melanomas [1,14,16,17,24,30]. Other neoplasms arising in teratomas include carcinoid tumors, thyroidtype tumors, and neuroectodermal tumors [3,12,22,25].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and immunohistochemical features of a sebaceous carcinoma arising within a benign dermoid cyst of the ovary

Ribeiro‐Silva

Chang

Bisson³

et al. 2003

Virchows Archiv

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Pure sebaceous neoplasms arising in dermoid cysts of the ovary are exceedingly rare. A 63-year-old female with abdominal swelling and pain underwent a right salpingo-oophorectomy that showed a unilocular cyst weighing 830 g and measuring 15x12x10 cm, filled with sebaceous material containing a few hair shafts. The cyst wall exhibited plaques protruding into the cavity of the cyst. Microscopy revealed a dermoid cyst with nests and lobules of atypical and infiltrating sebaceous cells surrounded by basaloid cells. The tumor cells stained diffusely for high-molecular-weight cytokeratins and focally for cytokeratin 7, cytokeratin 19, epithelial membrane antigen and carcinoembryonic antigen in the immunohistochemistry study. Low-molecular-weight cytokeratins, cytokeratin 20, vimentin, S100, p63, estrogen receptor, progesterone receptor, p53 and c-erbB-2 were negative in tumoral cells. The proliferative labeling index (Ki67 and proliferating cell nuclear antigen) was low. Basal cell carcinoma with sebaceous differentiation and sebaceoma must be considered in the differential diagnosis. However, the presence of obvious malignant sebaceous differentiation in nearly every tumor nest and lack of peripheral palisading and peri-tumoral myxoid stroma excluded these diagnoses. Some histogenetic concepts relevant to this case are discussed along with a brief review of this neoplasm. To our knowledge, this is the sixth case report of a sebaceous carcinoma arising in a mature cystic teratoma of the ovary.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological and immunohistochemical features of a sebaceous carcinoma arising within a benign dermoid cyst of the ovary

Ribeiro‐Silva

Chang

Bisson³

et al. 2003

Virchows Archiv

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“…Since the definition was established of the histopathological criteria for the diagnosis of fibrosarcoma, an important component of which is a count of ≥ 4 mitotic figures per 10 HPF2, a number of cases of ovarian fibrosarcoma have been reported with a wide heterogeneity in clinical and pathomorphological features (Table 1)2–14…”

Section: Discussionmentioning

confidence: 99%

“…One of the reasons for the reported heterogeneity of these ovarian tumors is related to the divergent histopathological criteria. In the vast majority of cases, the diagnosis of ovarian fibrosarcoma is made on the basis of the count of mitotic figures, underestimating nuclear atypias and other features such as the presence of necrosis and hemorrhage2–14. Recently, a study published by Irving et al noted that cases of ovarian fibromatous tumor showing very high mitotic count, but blunt nuclei, do not usually exhibit an aggressive course of disease and should be diagnosed as ‘mitotically active cellular fibromas’ instead of fibrosarcomas15.…”

Section: Discussionmentioning

confidence: 99%

Sonographic features of primary ovarian fibrosarcoma: a report of two cases

Testa

Gaurilcikas²,

Licameli

et al. 2008

Ultrasound in Obstet & Gyne

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“…Sarcomatous transformation is even more unusual; only a few cases of leiomyosarcoma, chondrosarcoma, osteosarcoma, angiosarcoma, fibrosarcoma and malignant fibrous histiocytoma have ever been described. 1 Herein, we report a case of malignant fibrous histiocytoma arising in a mature cystic teratoma. According to our review of the literature, this is only the third account of such a case.…”

Section: Malignant Fibrous Histiocytoma Arising In a Mature Cysticmentioning

confidence: 97%

Malignant Fibrous Histiocytoma Arising in a Mature Cystic Teratoma of the Ovary - A Case Report -

Lee

Jung

et al. 2010

Korean J Pathol

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A 50-year-old female patient presented with anorexia and weight loss. Pelvic computed tomography revealed a 12.5 × 7.3 cm heterogeneous mass in the left ovary. About 30% of the tumor was occupied by a mature cystic teratoma. The remaining solid portion was composed of fibrous and histiocytic elements, arranged in storiform patterns admixed with bizarre giant cells. The mitotic index was 8 per 10 high power fields, including atypical mitoses. The only immunopositivity was for vimentin. The tumor was diagnosed as a malignant fibrous histiocytoma arising in a mature cystic teratoma. To the best of our knowledge, this is only the third such case in the English language literature.

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Fibrosarcoma Associated with a Benign Cystic Teratoma of the Ovary

Cited by 22 publications

References 28 publications

Clinicopathological and immunohistochemical features of a sebaceous carcinoma arising within a benign dermoid cyst of the ovary

Clinicopathological and immunohistochemical features of a sebaceous carcinoma arising within a benign dermoid cyst of the ovary

Sonographic features of primary ovarian fibrosarcoma: a report of two cases

Malignant Fibrous Histiocytoma Arising in a Mature Cystic Teratoma of the Ovary - A Case Report -

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