Fibrosacroma of the vocal fold: a late complication of radiotherapy

Nageris, Ben I.; Elidan, Josef; Sherman, Yevgeni

doi:10.1017/s0022215100128713

Cited by 11 publications

(3 citation statements)

References 10 publications

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“…In 1978, Donaldson 17 described a fibrosarcoma of the larynx arising at the site of a squamous cell carcinoma previously treated by radiotherapy. A similar case was reported in 1994 by Nageris et al, 25 who described a rare case of f ibrosarcoma of the vocal cord extending into and obliterating the paralaryngeal space, following radiotherapy for a glottic squamous cell carcinoma. In 1984, Ferlito et al 19 reported a metachronous coexistence of laryn- geal mucosa-associated lymphoid tissue (MALT) lymphoma (of a low grade of malignancy) and squamous cell carcinoma, with the term "pseudolympho- An apparent association of epithelial and mesenchymal neoplasms of the larynx is not always confirmed on closer scrutiny; for example, it is important to distinguish solitary tumors manifesting bidirectional or multidirectional differentiation from true synchronous primary cancers of the larynx originating from 2 discrete, different malignant clones.…”

supporting

confidence: 78%

Synchronous and Metachronous Multiple Primary Laryngeal Malignancies

Ferlito¹,

Rinaldo²,

Ko³

et al. 1998

Ann Otol Rhinol Laryngol

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The article reviews the literature on synchronous and metachronous multiple primary malignant laryngeal tumors of the same phenotype, of different phenotypes, and of different histogenesis.The development of a second or even third primary cancer involving the same system is not uncommon. For instance, the association of cancer of the larynx with lung cancer has been increasing and can be explained by the presence of common pathogenetic factors acting in the respiratory system.Multiple primary carcinomas of the larynx are not uncommon, but their exact incidence has not been clearly defined. The occurrence of an additional malignancy in the larynx should not necessarily be interpreted as a treatment failure for the initial laryngeal tumor, since the second tumor may represent a de novo primary malignancy. 'The frequency of primary or multicentric neoplastic areas in the larynx is relevant to research work on carcinogenesis and to clinical matters, such as the early detection of a second primary cancer in the respiratory tract.Patients who have had a primary cancer of the respiratory system are particularly prone to develop subsequent primary tumors elsewhere in this system. There is evidence that multiple synchronous tumors may involve the larynx -an observation that points up the relevance of the concept of "field cancerization" or "condemned mucosa" to this anatomic region.Two distinct synchronous or metachronous malignant tumors of the same histologie type (as, for example, tumors exhibiting squamous differentiation) are not rare in the larynx. Honcamp 2 observed 3 squamous carcinomas in the same larynx. Rabbet 3 reported 3 distinct primary cases of multicentric carcinoma of the larynx. Heiner 4 described a patient with 3 separate squamous carcinomas of the larynx. (The third primary malignant lesion was in situ carcinoma.) Thirty of 535 patients (5.6%) followed up over a 5-to 25-year period after treatment for carcinoma of the vocal fold developed a second primary laryngeal carcinoma. 5Second primary laryngeal cancer in limited (Tl or T2) glottic cancer has been observed in patients treated with different modalities -surgery or radiotherapy -and the incidence of a second primary laryngeal cancer is higher in the group of patients treated with surgery. In particular, in the group treated with surgery (118 patients), 9 of the 32 second primary cancers occurred in the larynx; in the group of irradiated patients (185 patients), 1 of the 23 second primary cancers occurred in the larynx. New malignancies occurring within the larynx were classified as second primary tumors if they occurred more than 5 years after treatment. 6

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supporting

confidence: 78%

Synchronous and Metachronous Multiple Primary Laryngeal Malignancies

Ferlito¹,

Rinaldo²,

Ko³

et al. 1998

Ann Otol Rhinol Laryngol

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“…There are sporadic reported cases of RIS, such as osteosarcoma and angiosarcoma [4,5]. Nageris et al [6] reported fibrosarcoma as a late complication of radiotherapy. In this case, the patient appeared with fibrosarcoma 5 years after laser surgery and radiotherapy of laryngeal squamous carcinoma.…”

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confidence: 99%

Radiation-induced Fibrosarcoma of the Larynx: a Case Report and Review of Literature

Gong

Huang

2021

Preprint

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Background: Radiation-induced sarcoma (RIS) is a rare complication following radiotherapy of head and neck carcinoma. It occurs mostly within the limits of the irradiated area and always suggests a poor prognosis. Case summary: Herein, we reported one case of a 61-year-old male with laryngeal squamous cell carcinoma (SCC), who had a history of surgery and radiotherapy. In 2014, this patient was admitted in our hospital for increasing hoarseness five years after surgery and radiotherapy. Finally, the patient was diagnosed as fibrosarcoma and was given total laryngectomy, the patient was died in August 2019 within following up. In addition, the clinical and pathological characteristics of similar cases and their probable tumorgenesis were also reviewed. Conclusion: RIS is increasingly important. They usually occur mostly within the limits of the irradiated area. SCC is the most common malignant tumour in the head and neck region, and radiotherapy is a primary adjuvant therapy method. For patients receiving radiotherapy, physicians should follow up more carefully for early detection the RISs. For sarcomas occurring in head and neck region, especially RIS, complete surgical resection is the primary treatment. The choice of radiotherapy and chemotherapy should be more cautious. The prognosis of primary sarcomas or RISs is still controversial. No matter primary sarcomas or RISs, we believe that complete surgical resection should be considered as a top priority in surgery.

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“…Radyoterapi sonrası tedavi amacıyla da olsa radyasyon uygulanan alanlarda, ilk tümörden farklı histolojik tiplerde ikinci tümör gelişen olgular da bildirilmiştir. 2 Literatürdeki bu vakaların büyük kısmı osteojenik sarkomlardır. Baş boyun malignitelerinin tedavisinde radyoterapi oldukça sık kullanılır.…”

Section: Introductionunclassified

Fibrosarcoma of the ethmoid region

Akyol¹,

Ergin²

2013

Turk Arch Otolaryngol

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Fibrosacroma of the vocal fold: a late complication of radiotherapy

Cited by 11 publications

References 10 publications

Synchronous and Metachronous Multiple Primary Laryngeal Malignancies

Synchronous and Metachronous Multiple Primary Laryngeal Malignancies

Radiation-induced Fibrosarcoma of the Larynx: a Case Report and Review of Literature

Fibrosarcoma of the ethmoid region

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