Fibronectin-Integrin (α5β1) Modulates Migration and Invasion of Murine Melanoma Cell Line B16F10 by Involving MMP-9

Sil, Hrishikesh; Sen, Triparna; Chatterjee, Amitava

doi:10.3727/096504011x13079697132925

Cited by 49 publications

(47 citation statements)

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“…How theta bursts produce these effects remains to be determined although it is known that the stimulation pattern engages kinases and small GTPases (Chen et al, 2007(Chen et al, , 2010b) that regulate integrin status in various types of adhesion junctions (Munshi and Stack, 2006;Jin et al, 2011;Sil et al, 2011). Moreover, recent studies showed that LTP induction leads to focal activation of matrix metalloproteinase-9 (MMP-9; Nagy et al, 2006; Bozdagi et al, 2007), an extracellular proteinase that cleaves matrix proteins and thereby generates integrin ligands .…”

Section: Discussionmentioning

confidence: 99%

Integrin Dynamics Produce a Delayed Stage of Long-Term Potentiation and Memory Consolidation

Babayan

Kramár

Barrett³

et al. 2012

J. Neurosci.

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Memory consolidation theory posits that newly acquired information passes through a series of stabilization steps before being firmly encoded. We report here that in rat and mouse, hippocampus cell adhesion receptors belonging to the ␤1-integrin family exhibit dynamic properties in adult synapses and that these contribute importantly to a previously unidentified stage of consolidation. Quantitative dual immunofluorescence microscopy showed that induction of long-term potentiation (LTP) by theta burst stimulation (TBS) activates ␤1 integrins, and integrin-signaling kinases, at spine synapses in adult hippocampal slices. Neutralizing antisera selective for ␤1 integrins blocked these effects. TBS-induced integrin activation was brief (Ͻ7 min) and followed by an ϳ45 min period during which the adhesion receptors did not respond to a second application of TBS. Brefeldin A, which blocks integrin trafficking to the plasma membrane, prevented the delayed recovery of integrin responses to TBS. ␤1 integrin-neutralizing antisera erased LTP when applied during, but not after, the return of integrin responsivity. Similarly, infusions of anti-␤1 into rostral mouse hippocampus blocked formation of long-term, object location memory when started 20 min after learning but not 40 min later. The finding that ␤1 integrin neutralization was effective in the same time window for slice and behavioral experiments strongly suggests that integrin recovery triggers a temporally discrete, previously undetected second stage of consolidation for both LTP and memory.

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Section: Discussionmentioning

confidence: 99%

Integrin Dynamics Produce a Delayed Stage of Long-Term Potentiation and Memory Consolidation

Babayan

Kramár

Barrett³

et al. 2012

J. Neurosci.

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“…The most imaginable scenario is that signaling to MMP-9 occurs through both pathways. Supporting evidence from Sil et al demonstrated that adhesion to FN induced MMP-9 mRNA, protein, and activity in murine melanoma cells via the alpha5beta1 integrin and the FAK, ERK, and PI3K pathways [157]. Preliminary data in this laboratory suggest treatment of CD9-HT1080 cells with U0126 and PD98059 to block pro-MMP-9 release to levels comparable with Mock-HT1080 cells (Figure B-3).…”

Section: Chapter 4 Cd9 Contributions To Cancer Cell Biology * †supporting

confidence: 53%

Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man

Herr¹

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“…The Erk signaling pathway is reported to participate in integrin function (35,36). However, it is not known if Erk signaling plays a role in thrombin-mediated integrin function.…”

Section: Discussionmentioning

confidence: 99%

Cooperation of protease-activated receptor 1 and integrin ανβ5 in thrombin-mediated lung cancer cell invasion

Zhu¹,

Wang²,

Wu³

et al. 2012

Oncology Reports

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Abstract. Protease-activated receptor 1 (PAR1) and integrins play an important role in thrombin-mediated tumor cell invasion. However, the role of PAR1 and integrin α ν β 5 and the relationship between the two receptors in thrombin-induced lung cancer invasion remains unknown. Moreover, the mechanisms through which immobilized thrombin facilitates tumor invasion are poorly understood. In this study, both native and immobilized thrombin promoted lung cancer cell adhesion, migration and extracellular signal-regulated kinase phosphorylation. Integrin α ν β 5 is involved in both native and immobilized thrombin-mediated tumor cell invasion; PAR1 had no effect on immobilized thrombin-mediated cell invasion. PAR1 and integrin α ν β 5 colocalized on the surface of native thrombin-treated cells. This study suggests that targeting of integrin α ν β 5 or the PAR1-integrin α ν β 5 complex may present an important therapeutic opportunity to prevent lung cancer invasion.

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Fibronectin-Integrin (α5β1) Modulates Migration and Invasion of Murine Melanoma Cell Line B16F10 by Involving MMP-9

Cited by 49 publications

References 0 publications

Integrin Dynamics Produce a Delayed Stage of Long-Term Potentiation and Memory Consolidation

Integrin Dynamics Produce a Delayed Stage of Long-Term Potentiation and Memory Consolidation

Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man

Cooperation of protease-activated receptor 1 and integrin ανβ5 in thrombin-mediated lung cancer cell invasion

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