Fibronectin–Carbon‐Nanotube Hybrid Nanostructures for Controlled Cell Growth

Namgung, Seon; Kim, Taekyeong; Baik, Ku Youn; Lee, Minbaek; Nam, Jwa Min; Hong, Seok Hoon

doi:10.1002/smll.201001513

Cited by 73 publications

(73 citation statements)

References 21 publications

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“…99 When fibronectin immobilization on CNT monolayer is done, it leads to an increase in seeding efficiency and on the proliferation rate of stem cells over the scaffold, proving the importance of the interaction between CNTs and ECM proteins on cell metabolism. 100 Functionalization of CNTs through ECM protein immobilization was successful in producing a biomaterial that can be used in biomedical engineering. 3 MacDonald et al noted that matrices containing 2-wt% SWNTs showed some delay in the compaction of the gel during the first 3 days of their experiment: an indication that the CNTs improve the mechanical properties of the gel when added to it.…”

Section: Similarity Of Nanotubes With Ecmmentioning

confidence: 99%

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Tonelli¹,

Santos²,

Gomes³

et al. 2012

IJN

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Abstract:In recent years, significant progress has been made in organ transplantation, surgical reconstruction, and the use of artificial prostheses to treat the loss or failure of an organ or bone tissue. In recent years, considerable attention has been given to carbon nanotubes and collagen composite materials and their applications in the field of tissue engineering due to their minimal foreign-body reactions, an intrinsic antibacterial nature, biocompatibility, biodegradability, and the ability to be molded into various geometries and forms such as porous structures, suitable for cell ingrowth, proliferation, and differentiation. Recently, grafted collagen and some other natural and synthetic polymers with carbon nanotubes have been incorporated to increase the mechanical strength of these composites. Carbon nanotube composites are thus emerging as potential materials for artificial bone and bone regeneration in tissue engineering.

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Section: Similarity Of Nanotubes With Ecmmentioning

confidence: 99%

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Tonelli¹,

Santos²,

Gomes³

et al. 2012

IJN

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show abstract

“…In particular, CNTs have emerged as a promising functional nanomaterial for bone regeneration as they can promote osteogenesis of mesenchymal stem cells [5], as well as osteoblast functioning [6], and bone calcification [7]. Previous studies reported that extracellular matrix proteins adsorbed on CNTs mediate cell adhesion and subsequently remodel cell cytoskeleton [8,9]. The cytoskeletal remodelling of the cells activates focal adhesion kinase and triggers cell signalling that promotes osteogenic differentiation [8,9].…”

Section: Introductionmentioning

confidence: 98%

“…Previous studies reported that extracellular matrix proteins adsorbed on CNTs mediate cell adhesion and subsequently remodel cell cytoskeleton [8,9]. The cytoskeletal remodelling of the cells activates focal adhesion kinase and triggers cell signalling that promotes osteogenic differentiation [8,9]. However, despite all the findings discovered through in vitro cell culture on CNTs, in vivo applications of CNTs are still very limited due to the difficulties to fabricate three-dimensional (3D) microporous structures with nano-scale CNTs [9e12].…”

Section: Introductionmentioning

confidence: 99%

In situ hybridization of carbon nanotubes with bacterial cellulose for three-dimensional hybrid bioscaffolds

Park¹,

Park²,

Jo³

et al. 2015

Biomaterials

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“…It is also well-known that cell adhesion to ECM is usually dictated by focal adhesions (FAs), which link actin cytoskeleton to ECM and provide regions for signal transduction to regulate cell growth. 38 Similarly our results suggest that effective adsorption of growth factor proteins of the cell and nutrients in the culture media contribute promotion of cell proliferation and differentiation on SWCNT films. Therefore, the strong protein adsorption ability of SWCNT films is one of the possible reasons for enhanced proliferation and differentiation, in addition to nanoporous structures of network SWCNT films.…”

Section: Acs Applied Materials and Interfacesmentioning

confidence: 79%

Random Networks of Single-Walled Carbon Nanotubes Promote Mesenchymal Stem Cell’s Proliferation and Differentiation

Lee

Shim

Khalid

et al. 2015

ACS Appl. Mater. Interfaces

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Studies on the interaction of cells with single-walled carbon nanotubes (SWCNTs) have been receiving increasing attention owing to their potential for various cellular applications. In this report, we investigated the interactions between biological cells and nanostructured SWCNTs films and focused on how morphological structures of SWCNT films affected cellular behavior such as cell proliferation and differentiation. One directionally aligned SWCNT Langmuir-Blodgett (LB) film and random network SWCNT film were fabricated by LB and vacuum filteration methods, respectively. We demonstrate that our SWCNT LB and network film based scaffolds do not show any cytotoxicity, while on the other hand, these scaffolds promote differentiation property of rat mesenchymal stem cells (rMSCs) when compared with that on conventional tissue culture polystyrene substrates. Especially, the SWCNT network film with average thickness and roughness values of 95 ± 5 and 9.81 nm, respectively, demonstrated faster growth rate and higher cell thickness for rMSCs. These results suggest that systematic manipulation of the thickness, roughness, and directional alignment of SWCNT films would provide the convenient strategy for controlling the growth and maintenance of the differentiation property of stem cells. The SWCNT film could be an alternative culture substrate for various stem cells, which often require close control of the growth and differentiation properties.

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Fibronectin–Carbon‐Nanotube Hybrid Nanostructures for Controlled Cell Growth

Cited by 73 publications

References 21 publications

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

In situ hybridization of carbon nanotubes with bacterial cellulose for three-dimensional hybrid bioscaffolds

Random Networks of Single-Walled Carbon Nanotubes Promote Mesenchymal Stem Cell’s Proliferation and Differentiation

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