Fibronectin and its soluble EDA-FN isoform as biomarkers for inflammation and sepsis

Abstract

Lemańska-Perek A, Adamik B. Fibronectin and its soluble EDA-FN isoform as biomarkers for inflammation and sepsis.

Aqueous Fibronectin Correlates With Severity of Macular Edema and Visual Acuity in Patients With Branch Retinal Vein Occlusion: A Proteome Study

“…Fibronectin is a 230 to 270 kDa glycoprotein that exists in a soluble form and an insoluble form. [34][35][36] The soluble form in the aqueous humor regulates thrombosis and accelerates wound healing. 35,36 At the wall of injured vessels the soluble form of fibronectin is rapidly deposited and promotes platelet aggregation when linked with fibrin.…”

“…[34][35][36] The soluble form in the aqueous humor regulates thrombosis and accelerates wound healing. 35,36 At the wall of injured vessels the soluble form of fibronectin is rapidly deposited and promotes platelet aggregation when linked with fibrin. 37 Our data indicated that the increased level of fibronectin was associated with retinal ischemia as the content of fibronectin was higher in BRVO with greater than 5 disc areas of retinal nonperfusion.…”

Construction of fibronectin conditional gene knock-out mice and the effect of fibronectin gene knockout on hematopoietic, biochemical and immune parameters in mice

“…FN has multiple functional domains that can bind to integrin, collagen, fibrin and heparin, and participate in cell adhesion, migration, proliferation and differentiation ( Hynes, 2012 ; Mao & Schwarzbauer, 2005 ; Pankov, 2002 ). More and more studies have demonstrated that FN plays an important role in assessement the severity of severe infection and sepsis ( Lemańska-Perek & Adamik, 2019 ; Ruiz Martin et al, 2004 ).…”

Serum Glycoproteomic Alterations in Patients with Diabetic Retinopathy

“…Two glycopeptides of fibronectin (sites N-542 and T-2156) showed changes in glycosylation in patients with DR. The expression of fibronectin in the retina, plasma, and kidneys has been shown to be increased in diabetes and has been associated with inflammation and retinal dysfunction [ 18 , 19 , 20 ]. Fibronectin is involved in ECM remodeling via cell-adhesion, migration, and thrombosis regulation [ 18 ].…”

“…Our analysis revealed that several altered glycoproteins, including fibronectin, antithrombin-III, alpha-2-HS-glycoprotein, inter-alpha-trypsin inhibitor heavy chain H1, hemopexin, and vitronectin are involved in peptidolytic processes through regulatory effects [ 18 , 31 , 32 , 33 , 34 , 35 ]. The altered glycosylation of serum peptidase regulators may offer novel insights into the pathogenesis of DR. ITIH1, a peptidase inhibitor, has previously been identified to be a potential biomarker of DR [ 36 ].…”