Fibromyalgia and Risk of Dementia—A Nationwide, Population-Based, Cohort Study

Tzeng, Nian Sheng; Chung, Chi Hsiang; Liu, Feng Cheng; Chiu, Yu-Hsiang; Chang, Hsin‐An; Yeh, Chin Bin; Huang, San Yuan; Lu, Ru Band; Yeh, Hui Wen; Kao, Yu Chen; Chiang, Wei Shan; Tsao, Chang Hui; Wu, Yung-Fu; Chou, Yu Ching; Lin, Fu Huang; Chien, Wu Chien

doi:10.1016/j.amjms.2017.09.002

Cited by 38 publications

(47 citation statements)

References 56 publications

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“…Our findings are broadly consistent with those of a nested-case control study of Taiwanese Nationals indicating an increased risk for dementia in adults with OA 14 and a cross-sectional study of Appalachian adults, which documented a strong association of OA and related joint pain to perceived memory loss 13 . Our findings are also in general agreement with cross-sectional 5,6,23 , caseecontrol 44,45 , and longitudinal studies 7,8,11 documenting significant associations of non-specific chronic pain 5e8,11 and other (non-OA) chronic pain conditions 5,6,44,45 to impairment in cognitive functioning. Notably, in one recent study of a small US cohort followed for an average of 4.4 years, PI was associated with significantly increased risk for incident dementia 7 .…”

Section: Discussionsupporting

confidence: 90%

Association of osteoarthritis and pain with Alzheimer's Diseases and Related Dementias among older adults in the United States

Ikram

Innes

Sambamoorthi

2019

Osteoarthritis and Cartilage

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Background: Emerging evidence suggests that Pain Interference (PI) and certain chronic pain conditions, including Osteoarthritis (OA) may be associated with risk for Alzheimer's disease and Related Dementias (ADRD). However, research exploring the relation of OA and PI to ADRD remains sparse. Objective: To assess the association of OA and PI to ADRD using cross-sectional data from a representative sample of USA adults aged 65 years. Design: Retrospective cross-sectional. Study sample: Older adults (age 65 years) drawn from the Medical Expenditure Panel Survey (MEPS, 2009e2015). Methods: OA was identified using both medical conditions files and participant responses to arthritisspecific queries. ADRD was ascertained using the medical conditions files. PI was defined as reported frequent PI with normal activities (PIA). OA and PIA were categorized as a composite variable: 1) OA with PIA; 2) OA without PIA; 3) No OA with PIA; and 4) No OA and no PIA (reference group). Adjusted associations of OA and PIA to ADRD were assessed using logistic regression and adjusted for biological, demographic, socioeconomic , lifestyle, and health conditions. Results: Overall, 27.1% had OA, of whom 47.6 % reported PIA vs 31.1% of those without OA; 2.8% had diagnosed ADRD. Adults with PIA either with or without OA had significantly higher odds of ADRD relative to those without OA or PIA (Adjusted odd ratios (AOR's) ¼ 1.37, 95%CI e 1.01, 1.86 (p ¼ 0.04) and 1.44, 95%CI e 1.13, 1.82 (p ¼ 0.003), respectively). Conclusion: PIA in both the presence and absence of OA remained significantly and positively associated with ADRD after adjustment for multiple confounders.

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Section: Discussionsupporting

confidence: 90%

Association of osteoarthritis and pain with Alzheimer's Diseases and Related Dementias among older adults in the United States

Ikram

Innes

Sambamoorthi

2019

Osteoarthritis and Cartilage

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“…26 The details of this program have been documented in previous studies. 17,27,28 The NHIRD registration files and the original claims data include the overall data of personal information and the disease coding.…”

Section: Design and Study Methodsmentioning

confidence: 99%

“…10 Other population-based studies have also shown that viral diseases of the skin, such as herpes simplex or herpes zoster infections, were associated with the increased risk of dementia, [11][12][13][14][15][16] and some studies have observed that treatment with antiherpetic antiviral medications could attenuate the risk of developing dementia in patients with herpetic virus infection. 17,18 Several studies have shown that HPV may be detected in neurological diseases, for example, in the brains of patients with pediatric epilepsy 19,20 and Rasmussen's encephalitis. 21 Furthermore, another study also found that HPV may also play a role in inducing oxidative and inflammatory response in Alzheimer's disease pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Increased risk of dementia in patients with genital warts: A nationwide cohort study in Taiwan

Lin

Chien

Chung

et al. 2020

The Journal of Dermatology

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Genital warts are a common sexually transmitted disease caused by human papillomavirus (HPV) infections. The prevalence of dementia is 4-8% in those aged 65 years or older in Taiwanese community studies, with a high social and economic burden for patients, family caregivers, the community and society. Previous studies have shown that viral infections such as herpes simplex and herpes zoster were associated with dementia. This study aimed to investigate the association between dementia and HPV infections. A population-based cohort study using data from Taiwan's National Health Insurance Research Database was conducted. Fine and Grays's survival analysis was employed to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for the association between genital warts and dementia. From all of the potential participants aged 50 years or more, a total of 16 116 patients were enrolled, including 4029 genital warts-infected patients, with 12 087 sex-, age-and indexed date-matched controls (1:3). The cumulative incidences of dementia were 10.72 per 10 3 person-years and 6.43 per 10 3 person-years in the genital warts and control group, respectively. There were 475 dementia cases from the genital warts cohort during the follow-up period of 15 years. The adjusted HR for dementia was 1.485 (95% CI, 1.321-1.668; P < 0.001) for genital warts patients after adjusting for all of the covariates. Our study indicates that genital warts infection may increase the risk of dementia.

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“…Tzeng et al ( 2018b ) described several possible limitations, and therefore concluded that the findings suggest association of FM with dementia, rather than causation, and that a longer follow-up period would help to clarify the long-term risks. However, in view of the study by Pridgen et al ( 2017 ) suggesting that herpes virus infections may contribute to FM, the linking factor—and probable causative agent—is HSV1.…”

Section: Recent Data From Other Diseases Relevant To Hsv1 and Cognitimentioning

confidence: 99%

“…The third article concerns FM and dementia, pursued by Taiwanese investigators again using the country’s insurance data, the rationale being that inflammation-related diseases or other pain disorders, such as headaches, have been shown to be associated with increased risk of dementia. Tzeng et al ( 2018b ) investigated 41,612 subjects with FM diagnosed between January 1, and December 31, 2000, and 124,836 controls without FM, matched for age, sex and index year. All subjects were aged 50 years or over.…”

Section: Recent Data From Other Diseases Relevant To Hsv1 and Cognitimentioning

confidence: 99%

Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease

Itzhaki

2018

Front. Aging Neurosci.

185

149

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Strong evidence has emerged recently for the concept that herpes simplex virus type 1 (HSV1) is a major risk for Alzheimer’s disease (AD). This concept proposes that latent HSV1 in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE-ε4) is reactivated intermittently by events such as immunosuppression, peripheral infection, and inflammation, the consequent damage accumulating, and culminating eventually in the development of AD. Population data to investigate this epidemiologically, e.g., to find if subjects treated with antivirals might be protected from developing dementia—are available in Taiwan, from the National Health Insurance Research Database, in which 99.9% of the population has been enrolled. This is being extensively mined for information on microbial infections and disease. Three publications have now appeared describing data on the development of senile dementia (SD), and the treatment of those with marked overt signs of disease caused by varicella zoster virus (VZV), or by HSV. The striking results show that the risk of SD is much greater in those who are HSV-seropositive than in seronegative subjects, and that antiviral treatment causes a dramatic decrease in number of subjects who later develop SD. It should be stressed that these results apply only to those with severe cases of HSV1 or VZV infection, but when considered with the over 150 publications that strongly support an HSV1 role in AD, they greatly justify usage of antiherpes antivirals to treat AD. Three other studies are described which directly relate to HSV1 and AD: they deal respectively with lysosomal changes in HSV1-infected cell cultures, with evidence for a role of human herpes virus type 6 and 7 (HHV6 and HHV7) in AD, and viral effects on host gene expression, and with the antiviral characteristics of beta amyloid (Aβ). Three indirectly relevant studies deal respectively with schizophrenia, relating to antiviral treatment to target HSV1, with the likelihood that HSV1 is a cause of fibromyalgia (FM), and with FM being associated with later development of SD. Studies on the link between epilepsy, AD and herpes simplex encephalitis (HSE) are described also, as are the possible roles of APOE-ε4, HHV6 and HSV1 in epilepsy.

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Fibromyalgia and Risk of Dementia—A Nationwide, Population-Based, Cohort Study

Cited by 38 publications

References 56 publications

Association of osteoarthritis and pain with Alzheimer's Diseases and Related Dementias among older adults in the United States

Association of osteoarthritis and pain with Alzheimer's Diseases and Related Dementias among older adults in the United States

Increased risk of dementia in patients with genital warts: A nationwide cohort study in Taiwan

Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease

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