Fibromuscular Dysplasia: State of the Science and Critical Unanswered Questions

Olin, Jeffrey W.; Gornik, Heather L.; Bacharach, J. Michael; Biller, José; Fine, Lawrence J.; Gray, Bruce H.; Gray, William A.; Gupta, Rishi; Hamburg, Naomi M.; Katzen, Barry T.; Lookstein, R.; Lumsden, Alan B.; Newburger, Jane W.; Rundek, Tatjana; Sperati, C. John; Stanley, James C.

doi:10.1161/01.cir.0000442577.96802.8c

Cited by 391 publications

(554 citation statements)

References 275 publications

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“…Patients with FMD can present with arterial stenosis, beading, dissection, and aneurysm. In the US Registry for FMD cohort 2,3) , nearly 80% of registrants had renal FMD (presenting as hypertension), and almost three-quarters had carotid FMD (presenting as stroke or transient ischemic attack). Vertebral FMD was the third most common condition (36.6%).…”

Section: See Article Vol 23: 673-680mentioning

confidence: 99%

“…Vertebral FMD was the third most common condition (36.6%). Other reported sites of involvement include the mesenteric arteries, iliac arteries, intracranial vessels, and upper extremity (brachial) arteries 2,3) . Incidences of FMD are more common among females, accounting for approximately 90% of the adult cases.…”

Section: See Article Vol 23: 673-680mentioning

confidence: 99%

“…Incidences of FMD are more common among females, accounting for approximately 90% of the adult cases. Although FMD was thought to be a disease in young women, recent studies revealed that older individuals account for a large proportion of the total affected patients 2,3) . High prevalence of aneurysms (23.5%), sudden death (19.8%), and stroke (53.5%) among first-and second-degree family members in the US Registry suggests that FMD may represent an inherited systemic arteriopathy with diverse clinical phenotype 2,3) .…”

Section: See Article Vol 23: 673-680mentioning

confidence: 99%

“…Secondly, gene -environment interactions in FMD susceptibility ought to be considered. Two proposed interactions are smoking and estrogen 3,10) . Savard et al demonstrated that patients with renal FMD have a much higher smoking rate than the matched hypertensive controls 10) .…”

Section: See Article Vol 23: 673-680mentioning

confidence: 99%

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A New Plausible Link between Lysophosphatidylcholine, TGF-<i>β</i>, and Fibromuscular Dysplasia

Shimabukuro

2016

J Atheroscler Thromb

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Section: See Article Vol 23: 673-680mentioning

confidence: 99%

Section: See Article Vol 23: 673-680mentioning

confidence: 99%

Section: See Article Vol 23: 673-680mentioning

confidence: 99%

Section: See Article Vol 23: 673-680mentioning

confidence: 99%

See 2 more Smart Citations

A New Plausible Link between Lysophosphatidylcholine, TGF-<i>β</i>, and Fibromuscular Dysplasia

Shimabukuro

2016

J Atheroscler Thromb

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“…Histologically, FMD is broadly classified on the basis of the arterial layer involved into intimal, medial and perimedial fibroplasia. Clinically, FMD can manifest as arterial stenosis, occlusion, aneurysm, or dissection [1][2][3][4]. A very strong association between FMD and Spontaneous Coronary Artery Dissection (SCAD) has been established in several studies [3,5].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous coronary artery dissection secondary to intimal fibromuscular dysplasia (RCD code: I-1C.O)

Tariq

Sharkey

2017

Journal of Rare Cardiovascular Diseases

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Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory arterial disease of unknown etiology. Histologically, FMD is classified on the basis of arterial layer involved into intimal, medial and perimedial types. The medial form represents approximately 80% of the cases of FMD, perimedial and intimal forms are rare and account for 10% and 5% of the cases respectively. Clinically, FMD can manifest as arterial stenosis, occlusion, aneurysm or dissection. Coronary artery manifestations of FMD are rare but potentially fatal. Most cases present as a dissection of the involved coronary artery or its branch, which clinically leads to unstable angina, myocardial infarction, left ventricular dysfunction, or potentially sudden cardiac death. Various recent studies have established FMD as the leading risk factor for Spontaneous Coronary Artery Dissection (SCAD). We present autopsy findings of a 71 year old woman who suffered a spontaneous dissection of the posterior descending artery secondary to FMD-intimal type. The optimal diagnostic and treatment guidelines for SCAD secondary to FMD have not been established due to the lack of evidence. Further research into the pathogenesis, molecular and cellular biology, epidemiology and clinical management of FMD and its coronary artery manifestations is required. JRCD 2017; 3 (2): 56-58

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Association of Multifocal Fibromuscular Dysplasia in Elderly Patients With a More Benign Clinical Phenotype

et al. 2018

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Fibromuscular Dysplasia: State of the Science and Critical Unanswered Questions

Cited by 391 publications

References 275 publications

A New Plausible Link between Lysophosphatidylcholine, TGF-<i>β</i>, and Fibromuscular Dysplasia

A New Plausible Link between Lysophosphatidylcholine, TGF-<i>β</i>, and Fibromuscular Dysplasia

Spontaneous coronary artery dissection secondary to intimal fibromuscular dysplasia (RCD code: I-1C.O)

Association of Multifocal Fibromuscular Dysplasia in Elderly Patients With a More Benign Clinical Phenotype

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