Fibrolamellar hepatocellular carcinoma that was successfully treated with surgical resection: a case report

Na, Seong Kyun

doi:10.17998/jlc.2022.06.10

Cited by 1 publication

(4 citation statements)

References 19 publications

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“…Although they are not specific for this carcinoma, these findings, along with clinical presentation and imaging, can help provide a diagnosis. The DNAJB1-PRKACA fusion gene can also aid in differentiating FLHCC from HCC since it is not present in the latter case [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pathology remains the gold standard for diagnosis, and FLHCC tumor cells will demonstrate an eosinophilic cytoplasm with prominent nuclei and a fibrous stroma arranged in parallel lamellae [ 5 , 8 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Surgical resection remains the mainstay for treatment, although these tumors are aggressive, and recurrence of the carcinoma is common because of the large tumor size and the majority of patients presenting at an advanced stage [ 1 , 3 , 4 , 8 , 10 ]. Patients unable to undergo resection due to metastasis or major vessel involvement have a 5-year survival rate of 0-5% in comparison to a 58-82% rate of those who underwent surgery [ 4 , 7 , 8 ]. Favorable prognostic indicators include female gender and locoregional disease without lymph node involvement [ 3 , 4 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…About 50% of patients affected present at advanced stages when the carcinoma has already metastasized, negatively affecting their clinical course [ 1 , 6 ]. However, if detected early enough, surgical resection significantly improves survival outcomes [ 1 , 7 , 8 ]. The low incidence of the carcinoma makes it challenging to recruit patients for clinical trials, and as a result, treatment options for FLHCC are limited [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Fibrolamellar Hepatocellular Carcinoma (FLHCC) in a Young Patient Presenting With Nausea and Vomiting After a Greasy Meal

Ismail,

Singh,

Elaskandrany

et al. 2024

Cureus

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Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare and distinct subtype of liver cancer, predominantly affecting younger patients without underlying liver diseases. This case report discusses a unique presentation of FLHCC in a 38-year-old male with a past medical history of a well-controlled seizure disorder. The patient presented with nausea, vomiting, and abdominal pain following a fatty meal. Laboratory tests revealed elevated liver enzymes and anemia, and imaging showed a large hepatic lesion. Initial management included a septic workup and broad-spectrum antibiotics. However, a liver biopsy performed subsequently revealed the presence of FLHCC. The patient underwent a successful open right hepatectomy and was managed postoperatively with consideration of his seizure disorder. Follow-up at six months showed a stable postoperative condition without any evidence of recurrence. The diagnosis of FLHCC is challenging due to its rarity and nonspecific presentation. The case emphasizes the importance of considering FLHCC in the differential diagnosis of hepatic lesions, particularly in young patients. Surgical resection remains the primary treatment modality. This case underscores the importance of a thorough evaluation of hepatic lesions, especially in younger patients. It also illustrates the complexities in managing patients with FLHCC, requiring a multidisciplinary approach for optimal outcomes. Further research is necessary to better understand the pathogenesis of FLHCC and to develop more effective treatment strategies.

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Section: Discussionmentioning

confidence: 99%