Fibrolamellar hepatocarcinoma: radiology, management, and pathology

Wong, Lufee; Link, Daniel P.; Frey, C. F.; Ruebner, R. H.; Tesluk, Henry; Pimstone, Neville R.

doi:10.2214/ajr.139.1.172

Cited by 38 publications

(9 citation statements)

References 8 publications

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“…Satellite nodules may also be present. Abundance of fibrosis distributed in bands or laminae (hence fibrolamellar) is a hallmark of this neoplasm [68,69,70,71,72].…”

Section: Fibrolamellar Carcinomamentioning

confidence: 99%

Focal liver lesions: MR imaging–pathologic correlation

et al. 2001

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Magnetic resonance signal intensity of focal liver lesions is affected by numerous pathologic factors. Lesion histologic features, such as cellularity, vascularity, stromal component, and intratumoral necrosis or hemorrhage, strongly affect T1 and T2 relaxation times. Additionally, intracellular content of certain substances, such as glycogen, fat, melanin, iron, and copper, may also have a substantial role in determining MR signal behavior. In this review we discuss the correlations between MR imaging features and pathologic findings in benign and malignant focal liver lesions. Knowledge of imaging-pathology correlations greatly assist in charac terizing focal lesions. Moreover, in certain tumor histotypes, such as hepatocellular carcinoma, careful analysis of lesion signal intensity may help predict the degree of tumor differentiation.

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“…Satellite nodules may also be present. Abundance of fibrosis distributed in bands or laminae (hence fibrolamellar) is a hallmark of this neoplasm [68,69,70,71,72].…”

Section: Fibrolamellar Carcinomamentioning

confidence: 99%

Focal liver lesions: MR imaging–pathologic correlation

et al. 2001

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“…Common HCC is usually reported in the setting of chronic hepatitis or cirrhosis, whereas FL-HCC primarily occurs in a normal liver. [5][6][7][8] Fibrolamellar HCC is a very rare subtype, and accounts for only 0.9% of HCC. 9 The characteristics of FL-HCC are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Mediastinal metastasis from a fibrolamellar hepatocellular carcinoma: Report of a case

et al. 2010

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Fibrolamellar hepatocellular carcinoma (FL-HCC) is an uncommon clinicopathological variant of hepatocellular carcinoma (HCC). The etiology of FL-HCC is unknown, but FL-HCC is not associated with hepatic viruses or alcohol. Hepatocellular carcinoma usually occurs in cases of chronic hepatitis or cirrhosis, whereas FL-HCC predominantly occurs in a normal liver and in younger adults. Fibrolamellar HCC shows relatively slow growth, and late recurrence is common. Repeated resections for recurrences should be considered not only because there is a lack of other effective treatment options but also because FL-HCC shows a relatively better prognosis after a resection in comparison to common HCC. This report presents a case of a rare mediastinal metastasis from FL-HCC in a patient who had undergone a previous resection for retroperitoneal metastasis after the initial hepatic operation. This is the second report of the same case. This patient also had a mediastinal neurogenic tumor, and these mediastinal tumors were concurrently resected.

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“…Geralmente ele não está associado com cirrose, hepatite B ou C 13 . Quase todos os casos são diagnosticados em fase avançada, devido a maioria serem reconhecidos incidentalmente e\ou achado de massa abdominal palpável, sem apresentar sintomas 1,3,4,10 .…”

Section: Introductionunclassified

Hepatocarcinoma fibrolamelar (HFL): relato de caso

Maia¹,

Júnior²,

Viegas³

et al. 2009

ABCD, arq. bras. cir. dig.

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INTRODUÇÃO: O hepatocarcinoma fibrolamelar, variante do hepatocarcinoma, é neoplasia rara, responsável por 2% das de origem hepatocelular. RELATO DO CASO: Homem de 24 anos iniciou sintoma doloroso abdominal quatro meses antes da primeira consulta com hiporexia, emagrecimento, vômitos, aumento hepático e nodulação em hipocôndrio direito. Ressonância magnética abdominal mostrou lesão hepática heterogênea, hipervascular, com cicatriz central (provável calcificação), sugestivo de hepatocarcinoma fibrolamelar e presença de hepatomegalia moderada. Realizou-se trissegmentectomia hepática (segmentos VI, VII, VIII), com margem de segurança, sendo a via de acesso a por incisão subcostal direita. Houve confirmação de carcinoma hepatocelular (variante fibrolamelar) moderadamente diferenciado. Na evolução em seis meses encontrava-se bem com exame ultrassonográfico de controle normal, exceto sinais da ressecção efetuada. CONCLUSÃO: Apesar de prognóstico sombrio, o tratamento cirúrgico do hepatocarcinoma fibrolamelar é boa opção quando ampla hepatectomia pode ser realizada.

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Fibrolamellar hepatocarcinoma: radiology, management, and pathology

Cited by 38 publications

References 8 publications

Focal liver lesions: MR imaging–pathologic correlation

Focal liver lesions: MR imaging–pathologic correlation

Mediastinal metastasis from a fibrolamellar hepatocellular carcinoma: Report of a case

Hepatocarcinoma fibrolamelar (HFL): relato de caso

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