Fibrolamellar Carcinoma: A Multimodal Approach

Abstract

Fibrolamellar carcinoma is a rare variant of hepatocellular carcinoma not associated with cirrhosis or viral hepatitis. Serum alpha-fetoprotein levels are usually normal; the histology is of a well-differentiated tumor, and the staging is the same as for hepatocellular carcinoma. We describe the case of a female patient in her 4th decade of life with a diagnosis of fibrolamellar hepatocellular carcinoma with a multimodal approach. The rare incidence of this cancer and its unusual clinical presentation justifies reporting this case and highlights the importance of multidisciplinary teams in the treatment of cancer patients.

Mixed fibrolamellar hepatocellular carcinoma

“…1 It represents up to 25% of cases of fibrolamellar hepatocellular carcinoma and has been associated with a worse prognosis. 2 A 22-year-old previously healthy female patient presented with an abdominal discomfort for the past 2 months. The physical examination revealed a firm nodular mass in the right flank.…”

Mixed Fibrolamellar Hepatocellular Carcinoma

“…Mixed fibrolamellar hepatocellular carcinoma is a rare liver tumor defined by the presence of both pure fibrolamellar hepatocellular carcinoma and conventional hepatocellular components [1]. It represents up to 25% of cases of fibrolamellar hepatocellular carcinoma, and has been associated with a worse prognosis [2].…”