Fibroin-Gelatin Composite Stimulates the Regeneration of a Splinted Full-Thickness Skin Wound in Mice

Arkhipova, A. Yu.; Куликов, Д. А.; Мойсенович, А. М.; Andryukhina, V V; Chursinova, Yu V; Filyushkin, Yu. N.; Fedulov, A V; Бобров, М. А.; Mosalskaya, D.V.; Глазкова, П.А.; Куликов, А. В.; Nalivkin, A E; Молочков, А. В.; Semenov, D Yu

doi:10.1007/s10517-019-04656-0

Cited by 1 publication

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“…The particles injected into the defect area produced accelerated wound healing, improved re-epithelialization and formation of connective tissue, also replacing the damaged derma and stimulating regeneration of subcutaneous muscle and skin appendages. After 21 days, while only 50% control animals healed, all the experimental animals completely healed without cicatrices [ 84 ].…”

Section: Recent Advances On the Development Of Silk Fibroin-based mentioning

confidence: 99%

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

Pollini

Paladini

2020

Materials

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Nature is an incredible source of inspiration for scientific research due to the multiple examples of sophisticated structures and architectures which have evolved for billions of years in different environments. Numerous biomaterials have evolved toward high level functions and performances, which can be exploited for designing novel biomedical devices. Naturally derived biopolymers, in particular, offer a wide range of chances to design appropriate substrates for tissue regeneration and wound healing applications. Wound management still represents a challenging field which requires continuous efforts in scientific research for definition of novel approaches to facilitate and promote wound healing and tissue regeneration, particularly where the conventional therapies fail. Moreover, big concerns associated to the risk of wound infections and antibiotic resistance have stimulated the scientific research toward the definition of products with simultaneous regenerative and antimicrobial properties. Among the bioinspired materials for wound healing, this review focuses attention on a protein derived from the silkworm cocoon, namely silk fibroin, which is characterized by incredible biological features and wound healing capability. As demonstrated by the increasing number of publications, today fibroin has received great attention for providing valuable options for fabrication of biomedical devices and products for tissue engineering. In combination with antimicrobial agents, particularly with silver nanoparticles, fibroin also allows the development of products with improved wound healing and antibacterial properties. This review aims at providing the reader with a comprehensive analysis of the most recent findings on silk fibroin, presenting studies and results demonstrating its effective role in wound healing and its great potential for wound healing applications.

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Section: Recent Advances On the Development Of Silk Fibroin-based mentioning

confidence: 99%

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

Pollini

Paladini

2020

Materials

View full text Add to dashboard Cite

show abstract

Fibroin-Gelatin Composite Stimulates the Regeneration of a Splinted Full-Thickness Skin Wound in Mice

Cited by 1 publication

References 11 publications

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

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