Fibroepithelial lesions

Simsir, Aylin; Finkelstein, Alexander

doi:10.1017/cbo9780511979941.007

Cited by 2 publications

(3 citation statements)

References 32 publications

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“…Phyllodes tumors present as a firm and painless breast mass that may have grown rapidly. The radiologic impression is that of a rounded, well-defined lesion, but there may be heterogeneous shadowing and a focally irregular outline [1, 2, 11, 33]. …”

Section: Bland Spindle Cells and Benign Epithelial Elementsmentioning

confidence: 99%

“…Benign and borderline tumors make up 75 and 10% of phyllodes tumors, respectively, and are capable of recurrence but uncommonly metastasis. Malignant phyllodes tumors can recur and have a metastatic rate of 20–25% [1, 2, 11, 33]. …”

Section: Bland Spindle Cells and Benign Epithelial Elementsmentioning

confidence: 99%

“…Benign phyllodes tumor can show marked variation in stromal cellularity from sclerotic to moderately cellular from region to region. In general, low-grade phyllodes tumor has a lower epithelial to stromal ratio, with more cellular stromal fragments and increased numbers of elongate spindle nuclei and spindle cells in the background compared to fibroadenoma [6, 33]. When stromal tissue fragments show increased hypercellularity and any degree of nuclear enlargement and atypia, it is reasonable to raise the possibility of a benign phyllodes tumor, particularly if stroma is prominent, and categorize the tumor as “atypical” and warranting further biopsy.…”

Section: Bland Spindle Cells and Benign Epithelial Elementsmentioning

confidence: 99%

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Spindle Cell Lesions of the Breast on Fine-Needle Aspiration Biopsy: A Miscellany of Masses

Michelow

Field

2019

Acta Cytologica

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A variety of primary breast and metastatic lesions to the breast can present with spindle cell cytomorphology. These lesions may range from benign reactive or inflammatory lesions to high-grade malignancies. Spindle cell lesions of the breast are not often seen on fine-needle aspiration biopsy (FNAB) but need to be correctly managed when they are encountered. While mesenchymal lesions of the breast have a spindle morphology, lesions derived from the epithelium and myoepithelium can be spindled as well. By assessing if the lesion comprises spindle cells only or if other components such as epithelial cells are apparent and then determining whether the spindle cells appear bland or pleomorphic, together with close clinicoradiologic correlation and prudent use of ancillary tests, a variety of lesions can be diagnosed on FNAB. However, core needle biopsy or excision biopsy may be required in some patients. The cytomorphology, ancillary studies, and clinicoradiologic findings of a range of spindle cell lesions of the breast are further discussed.

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