Fibroblasts and Sympathetic Innervation of Blood Vessels

Soares‐da‐Silva, Patrício; Azevedo, Isabel

doi:10.1159/000158614

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…In various mammalian tissues, namely blood vessels and heart, there is a close association between fibroblasts and sympathetic innervation. This association is anatomic, as assessed by morphometric studies (Azevedo & Soares-da-Silva, 198 1; Soares-da-Silva & Azevedo, 1985) as well as functional. The functional link between fibroblasts and sympathetic innervation involves a repressive effect of the innervation upon the fibroblasts: .…”

Section: Discussionmentioning

confidence: 99%

“…In blood vessels, fibroblasts are in close proximity to adrenergic varicosities, an observation which led us to put forward the hypothesis of a functional sympathetic innervation of those cells (Azevedo & Soares-da-Silva, 198 1 ;Soares-da-Silva & Azevedo, 1985). This hypothesis has thereafter been strongly supported by the reactivity of fibroblasts to sympathetic denervation in veins (Branco, Albino-Teixeira, Azevedo & Osswald, 1984;Azevedo & Osswald, 1986), arteries and in the heart (Dimitriadou, Aubineau, Taxi & Seylaz, 1988;Sarmento, Soaresda-Silva, Albino-Teixeira & Azevedo, 1987).…”

Section: Introductionmentioning

confidence: 99%

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Effects of sympathetic denervation on liver fibroblasts: prevention by adenosine

Albino‐Teixeira

Matias

Soares‐da‐Silva

et al. 1990

Journal of Autonomic Pharmacology

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1. The effect of chemical denervation with 6-hydroxydopamine (6-OHDA) upon portal tract fibroblasts of dogs and rabbits was studied. 2. Denervation led to a significant increase in the density of portal tract fibroblasts both in the dog and in the rabbit. 3. Mast cells, present in the dog but not in the rabbit liver, were also significantly increased by denervation. 4. Noradrenaline depletion induced by reserpine did not increase the density of fibroblasts in the liver portal spaces of the dog. Mast cell density, however, was actually decreased when compared with control. 5. Continuous i.v. infusions of adenosine (10 micrograms kg-1h-1) to dogs totally prevented the effects of 6-OHDA-induced denervation upon fibroblast and mast cell densities in the portal space connective tissue. 6. It is concluded that the sympathetic nervous system is exerting a repressive effect on liver fibroblasts, as was found to occur in various other mammalian tissues. Mast cells, which are known to be activated in various pathological processes of fibrosis, appear to share with fibroblasts a modulating effect from the sympathetic nervous system. 7. The results strongly support the hypothesis of adenosine being the sympathetic trophic factor involved in the control of fibroblasts in the connective tissue of dog liver. A similar role for adenosine had previously been found in the dog saphenous vein.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of sympathetic denervation on liver fibroblasts: prevention by adenosine

Albino‐Teixeira

Matias

Soares‐da‐Silva

et al. 1990

Journal of Autonomic Pharmacology

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“…Evidence indicates that fibroblasts in blood vessels may be under sympathetic (monoaminergic) nervous control [13]. The distribution of fibroblasts and adrenergic nerves is parallel in the walls of at least some of the blood vessels and there is a closer anatomic relationship between the fibroblasts and adrenergic (monoaminergic) varicosities compared with the proximity of adrenergic varicosities with smooth muscle cells.…”

Section: Discussionmentioning

confidence: 99%

Myelinated fibers of spinal cord blood vessels—sensory innervation?

Heavner

Coates

Racz

2000

Current Review of Pain

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“…Since cocaine inhibits neuronal uptake, this shows that this type of uptake plays an important role in the mesenteric artery but not in the saphenous vein, insofar as spontaneous efflux is concerned. The artery has an adventitio-medial (symmetrical) type of innervation (Soares-da-Silva and Azevedo, 1985), whereas the vein has a medial (asymmetric) innervation (Coimbra et al, 1974); therefore, the close proximity of nerve varicosities favours uptake into neighbouring nerve elements in the former, but not in the latter vessel. Thus, strictly speaking, the phenomenon occurring in the mesenteric artery and only to a minor degree, if at all, in the saphenous vein, would be uptake (and not reuptake).…”

Section: Effects Of Ouabain and Cocaine On The Effluxmentioning

confidence: 99%

Spontaneous and Ouabain‐induced Eflux of Catecholamines and Dihydroxyphenylglycol in Two Canine Blood Vessels

Branco

Osswald

1988

Fundamemntal Clinical Pharma

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The spontaneous efflux of endogenous noradrenaline, dopamine, dihydroxyphenylglycol (DOPEG) from adrenergic nerve endings of 2 canine blood vessels (the mesenteric artery and the saphenous vein) were studied during 8 successive incubation periods of 15 min each. Extraneuronal uptake and O-methylation were minimized by the presence of adequate concentrations of tropolone and hydrocortisone. Both vessels had an efflux characterized by a decline in the 3 catechols, which was most marked for noradrenaline; the mesenteric artery lost larger amounts than the saphenous vein. Ouabain caused a large increase in the efflux of noradrenaline and dopamine and a reduction of DOPEG efflux. Cocaine had only a modest effect, more evident in the case of the mesenteric artery, increasing noradrenaline and reducing DOPEG effluxes. The combination of ouabain and cocaine had no additive effects, and the effects of ouabain were even reduced (on some parameters) by cocaine. Accordingly, the noradrenaline:DOPEG ratio was markedly increased by ouabain, but not by cocaine; cocaine significantly reduced the effects of ouabain. The ratio dopamine:noradrenaline was decreased by cocaine and by ouabain. Comparison of tissue content and efflux allowed us to conclude that apparently no significant de novo synthesis of noradrenaline occurred during the incubation period. We conclude that a fast and early component of spontaneous efflux is due to loss from the neurons and that its greater magnitude in the mesenteric artery may be due to differences in neuronal [Na+] and/or to differences in neuronal membrane adenosine triphosphatase activity. The results also suggest that neuronal reuptake plays only a minor role in the handling of spontaneously released noradrenaline.

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Fibroblasts and Sympathetic Innervation of Blood Vessels

Cited by 9 publications

References 9 publications

Effects of sympathetic denervation on liver fibroblasts: prevention by adenosine

Effects of sympathetic denervation on liver fibroblasts: prevention by adenosine

Myelinated fibers of spinal cord blood vessels—sensory innervation?

Spontaneous and Ouabain‐induced Eflux of Catecholamines and Dihydroxyphenylglycol in Two Canine Blood Vessels

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