Fibroblasts Adhesion to Laser-Modified Titanium Surfaces—A Systematic Review

Abstract

Objective: Laser treatment has been recently introduced in many fields of implant dentistry. The systematic review tried to address the question: “How does laser modification of titanium surface influence fibroblast adhesion?”. Methods: An electronic search of the PubMed and Scopus databases was performed. The following keywords were used: (laser) AND (fibroblast) AND (titanium) AND (implant OR disc) AND (proliferation OR adhesion). Initially, 136 studies were found. Ten studies met the inclusion criteria and were included in the review. All studies chosen to be included in the review were considered to have a low risk of bias. Results: Studies included in the review varied with laser parameters or ways of observing fibroblast behavior. Studies showed that fibroblasts tend to take different shapes and create extensions on modified surfaces and that their metabolic activity is more intense. One study concentrated on laser application and showed that three-directional laser application is the most successful in terms of fibroblast adhesion. Studies which concentrated more on laser parameters showed that too low energy density (lower or equal to 0.75 J/cm2) does not influence fibroblast adhesion. Increasing the energy density over 0.75 J/cm2 causes better cell adhesion of fibroblasts to the laser-modified sample. One included study focused on increasing titanium surface wettability, which also positively influenced cell adhesion. Conclusion: The studies included in the review proved a positive effect of laser-modified titanium surfaces on fibroblast adhesion. However, the application of an appropriate laser energy dose is crucial.

Evaluation of Adhesion and Viability of Human Gingival Fibroblasts on Strontium-Coated Titanium Surfaces: an in vitro Study

“…2,19 Furthermore, HGFs seeded onto Sr-coated and uncoated Ti surfaces were not morphologically different from untreated control fibroblast cells, further affirming the biocompatibility of both Sr and Ti. The adherent cells on Sr-coated Ti surfaces exhibited spindle-shaped (fusiform) morphology with cellular bridges that grew as Previous studies have shown that this cell morphology has a higher ability for attachment than round cells, 25 indicating that the fusiform morphology of adhered fibroblasts in this study might be associated with more cell adhesion and proliferation, and hence could provide better circumstances for successful implant treatment. Moreover, this study determined the quantity of live cells present in Sr-coated Ti surfaces by assessing their cell viability.…”

Surface Functionalization of Titanium-Based Implants with a Nanohydroxyapatite Layer and Its Impact on Osteoblasts: A Systematic Review

“…Conventional dental implants employed for such purposes are fabricated from titanium and its alloys [34]. The strategic utilization of titanium and its derivatives is predicated on their capacity to ensure biocompatibility, corrosion resistance, commendable physical properties, and an effective interaction with body cells, facilitating their adhesion to the implant surface [35,36]. Dentistry, as an ever-evolving scientific discipline, steadfastly pursues the advancement of dental materials and treatment outcomes [37].…”

Randomized Clinical Trial Comparing Insertion Torque and Implant Stability of Two Different Implant Macrogeometries in the Initial Periods of Osseointegration

“…However, clinical studies in patients are essential to prove the effectiveness of any material. Furthermore, in order to keep the peri-implant health condition, mechanical debridement therapy was periodically recommended to the patients, avoiding peri-implant diseases, keeping the stabilization of the surrounding hard and soft tissues [ 27 ], which can also have influence by the type of implant [ 28 ]. In addition, if necessary, the adjunctive use of ozone, glycine/erythritol, probiotics, and chlorhexidine treatment may be considered [ 29 ].…”