2019
DOI: 10.1038/s41590-019-0515-x
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Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

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Cited by 63 publications
(87 citation statements)
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“…In addition to nitric oxide production, sustained expression of MHCII by FRCs can mediate contraction of antigen-specific CD4 + T cells after peak expansion to limit prolonged inflammation caused by viral infection 116 . In contrast to mechanisms of restraint, FRCs can also enhance T cell fitness 117 . FRC-derived IL-6 leads to chromatin remodeling in CD8 + T cells to enhance their survival, metabolism and capacity to form tissueresident memory populations (Fig.…”
Section: Box 1 | Tertiary Lymphoid Structures (Tls) and Tls In Diseasementioning
confidence: 99%
“…In addition to nitric oxide production, sustained expression of MHCII by FRCs can mediate contraction of antigen-specific CD4 + T cells after peak expansion to limit prolonged inflammation caused by viral infection 116 . In contrast to mechanisms of restraint, FRCs can also enhance T cell fitness 117 . FRC-derived IL-6 leads to chromatin remodeling in CD8 + T cells to enhance their survival, metabolism and capacity to form tissueresident memory populations (Fig.…”
Section: Box 1 | Tertiary Lymphoid Structures (Tls) and Tls In Diseasementioning
confidence: 99%
“…On the one hand, FRCs regulate T cell function by attenuating self-reactivity through the presentation of peripheral tissue antigens and by reducing the proliferation of activated cells through the production of nitric oxide 5,6 . On the other hand, they are able to enhance immune responses by expressing costimulatory molecules, such as ICOSL, CD40 or IL-6, which promote IL-2 and TNF production by CD8 + T cells 51 . FRCs also respond to a variety of additional signals, including conduit fluid flow via the mechanosensitive ion channel Piezo1 52 , pathogen-associated molecular patterns 53 and activated T cells signals, like IL-17, which drive a metabolic reprograming of FRCs that promotes survival and proliferation 54 .…”
Section: Mesenchymal Cells In the Regulation Of Immunitymentioning
confidence: 99%
“…Lymph node fibroblastic reticular cells (FRCs) have contradictory roles in immune responses, such as inhibition of T cell proliferation via nitric oxide (32) and T cell reprogramming towards memory T cells via IL6 (33). Albeit FRCs in LNs acquire transcriptional programs typically associated with tumor escape (34), we considered the possibility that immune evasion in Col1a2 Cre + IAb fl/fl mice resulted from MHCII deletion in FRCs.…”
Section: Resultsmentioning
confidence: 99%