Abstract:Fibroblast growth factor receptors are tyrosine kinases that mediate cellular growth and differentiation during normal development and injury‐repair. To determine whether FGF receptor 3 (FGFR3) is involved in crypt morphogenesis, we examined the function of FGFR3 following intestinal injury and during gut development. FGFR3 is expressed in epithelial cells near the crypt base, where stem cells reside. Mice lacking FGFR3 develop fewer intestinal crypts (~49% of wt) and have reduced crypt survival following radi… Show more
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