Fibroblast Growth Factors in the Management of Acute Kidney Injury Following Ischemia-Reperfusion

Abstract

Ischemia-reperfusion injury (IRI), which is triggered by a transient reduction or cessation of blood flow followed by reperfusion, is a significant cause of acute kidney injury (AKI). IRI can lead to acute cell death, tissue injury, and even permanent organ dysfunction. In the clinic, IRI contributes to a higher morbidity and mortality and is associated with an unfavorable prognosis in AKI patients. Unfortunately, effective clinical drugs to protect patients against the imminent risk of renal IRI or treat already existing AKI are still lacking. Fibroblast growth factors (FGFs) are important regulators of key biological and pathological processes, such as embryonic development, metabolic homeostasis and tumorigenesis through the regulation of cell differentiation, migration, proliferation and survival. Accumulating evidence suggests that altered expression of endogenous FGFs is associated with IRI and could be instrumental in mediating the repair process. Therefore, FGFs have been proposed as potential biomarkers in the clinic. More importantly, exogenous FGF ligands have been reported to protect against renal IRI and display promising features for therapy. In this review, we summarize the evidence and mechanisms of AKI following IRI with a focus on the therapeutic capacity of several members of the FGF family to treat AKI after IRI.

miRNAs as Novel Biomarkers of Chronic Kidney Injury in Anabolic-Androgenic Steroid Users: An Experimental Study

“…Another gene target is fibroblast growth factor 18 (FGF18). It belongs to the FGF family that is involved in important biological and pathological processes, such as embryonic development, metabolic homeostasis and tumorigenesis through the regulation of cell differentiation, migration, proliferation and survival (Deng et al, 2020). As previously described, miR-21 was upregulated in injury with fibrosis both in mouse and human models (Chau et al, 2012).…”

Tilianin Reduces Apoptosis via the ERK/EGR1/BCL2L1 Pathway in Ischemia/Reperfusion-Induced Acute Kidney Injury Mice

“…Therefore, our present study identified tilianin as a promising therapeutic agent against I/R-induced AKI. Hypovolemia, hypotension, and heart failure are all common causes of transient ischemia, which contributed to AKI easily and explained for nearly one-third of patients requiring renal replacement therapy (Havasi and Borkan, 2011;Deng et al, 2020;Sabapathy et al, 2020). In I/R-induced AKI, proximal tubular epithelial cells were highly susceptible to injury, and apoptosis played a critical role in this process (de Ponte et al, 2021;Tonnus et al, 2021).…”

Role of HRTPT in kidney proximal epithelial cell regeneration: Integrative differential expression and pathway analyses using microarray and scRNA‐seq

“… 40 A recent review has detailed the possible role of FGF in the management of acute renal injury following ischaemia/reperfusion (IRI). 41 Evidence suggests that alterations in the expression of endogenous FGF are associated with IRI and may alter the repair process and discovered that exogenous FGF ligand might also be protective against IRI. Mouse model studies showed that FGFR2 knockout aggravated acute tubular dysfunction.…”