Fibroblast Growth Factors as Multifunctional Signaling Factors

Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning

“…High-affinity receptors for FGFs comprise a family of four transmembrane proteins (FGFR1-4) with intrinsic tyrosine activities of diverse functions (Johnson and Williams, 1993;Szebenyi and Fallon, 1999;Xu et al, 1999b). They share several common structural features, including a hydrophobic leader sequence, three immunoglobulin (Ig) like domains, an acidic box, a CAM (cell adhesion molecule) homology domain, a transmembrane region, and a divided tyrosine kinase (TK) domain.…”

Molecular and cellular biology of prostate cancer—the role of apoptosis as a target for therapy

“…FGFs bind to receptor tyrosine kinases (FGFRs), heparin sulphate proteoglycans (HSPG), and a cysteine-rich FGF receptor (CFR). 142 The FGFs signal through complex signalling pathways, in which there is extensive cross-talk with the pathways utilised by IGF, and TGF-b. 142,143 Four members (FGF-3 to FGF-6) have been shown to be oncogene products, and FGF-7 has been shown to be a growth factor for keratinocytes.…”

“…142 The FGFs signal through complex signalling pathways, in which there is extensive cross-talk with the pathways utilised by IGF, and TGF-b. 142,143 Four members (FGF-3 to FGF-6) have been shown to be oncogene products, and FGF-7 has been shown to be a growth factor for keratinocytes. 143 The ability of FGF-1 and FGF-2 to modulate the proliferation of endoepithelial cells re¯ects their angiogenic activity.…”

Temporal expression pattern of the insulin-like growth factor II and fibroblast growth factor transcripts in avian embryogenesis

“…Somatomedins (IGF-I and -II) comprise a family of the polypeptides with the growth-promoting effects in a wide variety of the cultured cells (Florini et al, 1991;Florini et al, 1996;Pirskanen et al, 2000). It has been shown that these factors stimulate the proliferation, differentiation and protein accretion of the cells derived from the avian embryos (Szebenyi and Fallon, 1999). In vitro analysis shows that IGFs promote the terminal cellular differentiation for an expressionand secretion-dependent autocrine mechanism.…”

“…They influence the formation of the primary body axis, neural axis, limbs and other embryonic structures. The activities of the FGFs depend on their coordination of the fundamental cellular functions, such as survival, replication, differentiation, adhesion and motility, through the effects on gene expression and on the cytoskeleton (Szebenyi and Fallon, 1999). The basic fibroblast growth factor, also known as bFGF or FGF2, is a particularly potent mitogen and promotes the cell survival by inhibiting the apoptosis.…”