Fibroblast growth factor receptors and their ligands in the adult rat kidney

Cancilla, Belinda; Davies, Ann D. M.; Cauchi, Jennifer; Risbridger, Gail P.; Bertram, John F.

doi:10.1046/j.1523-1755.2001.00781.x

Cited by 59 publications

(50 citation statements)

References 50 publications

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“…This interaction results in a series of molecular events that culminate in biological responses such as mitosis, differentiation or migration (Friesel and Maciag, 1999). In this regard, FGFR2 is localized throughout the whole cell and, as observed in some cases, staining up to the apical membrane, mainly in tubular segments of the inner stripe of the outer medulla, which is similar to what has been observed by other researchers (Cancilla et al, 2001). It can be speculated that the growth factor reaches its receptor from the blood vessels in normal conditions, but it can also reach the receptor through the tubular lumen when the fi ltration barrier is damaged.…”

Section: Discussionsupporting

confidence: 87%

Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure

et al. 2012

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Acute renal failure (ARF) can be caused by injuries that induce tissue hypoxia, which in turn can trigger adaptive or infl ammatory responses. We previously showed the participation of basic fi broblast growth factor (FGF-2) in renal repair. Based on this, the aim of this study was to analyze the effect of FGF-2 signaling pathway manipulation at hypoxia-induced protein levels, as well as in key proteins from the vasoactive systems of the kidney. We injected rat kidneys with FGF-2 recombinant protein (r-FGF) or FGF-2 receptor antisense oligonucleotide (FGFR2-ASO) after bilateral ischemia, and evaluated the presence of iNOS, EPO and HO-1, in representation of hypoxiainduced proteins, as well as COX-2, renin, kallikrein, and B2KR, in representation of the vasoactive systems of the kidney. A reduction in iNOS, HO-1, EPO, renin, kallikrein, B2KR, and in renal damage was observed in animals treated with r-FGF. The opposite effect was found with FGF-2 receptor down-regulation. In contrast, COX-2 protein levels were higher in kidneys treated with r-FGF and lower in those that received FGFR2-ASO, as compared to saline treated kidneys. These res ults suggest that the protective role of FGF-2 in the pathogenesis of ARF induced by I/R is a complex process, through which a differential regulation of metabolic pathways takes place.

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Section: Discussionsupporting

confidence: 87%

Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure

et al. 2012

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“…In our previous experiment, VEGF promoted cell outgrowth from aortic explant (Akita et al, 1996). According to Cancilla et al (2001) Schwartz and Liaw, 1993). This FGF prototype has pleiotropic effects in different cell and organ systems.…”

Section: Discussionmentioning

confidence: 99%

“…The fibroblast growth factors (FGFs) are a family of heparin-binding proteins involved in many biological processes in both developing and adult mammals, including cell proliferation, differentiation, and angiogenesis (Cancilla et al, 2001). The actions of the FGFs, particularly the basic form (basic FGF ¼ FGF-2), have been described in a large number of cells (for a review see Bikfalvi et al, 1997).…”

mentioning

confidence: 99%

Angiogenesis and Fibroblast Growth Factors (FGFs) in a Three-Dimensional Collagen Gel Culture

Nagatoro

Fujita

Murata

et al. 2003

Okajimas Folia Anat. Jpn.

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Summary: Small pieces of mouse aorta were cultured in collagen gels, and the formation of capillary-like tubes from the aortic explant was observed under phase-contrast and transmission electron microscopes. Migration of fibroblastic cells from the aortic explant occurred in 2 days. After about 10 days of culture, capillary-like tubes from the aortic explant were formed in the collagen gels. An immunohistochemical study on the collagen gel culture revealed the expression of fibroblast growth factor 2 (FGF-2) near the aortic explant at the active initial stage, with random migration of fibroblastic cells expressing FGF-9. mRNA was isolated from these cultures, and reverse transcription-polymerase chain reaction (RT-PCR) of the cultures revealed the expressions of both FGF-2 and FGF-9. Based on our results, we propose that FGF-9 is also related to angiogenic events.

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“…Functional FGFRs are transmembrane proteins characterized by an extracellular ligand-binding domain that contains up to three extracellular immunoglobulin (Ig)-like domains and an intracellular domain, which consists of a juxtamembrane region and a split tyrosine kinase domain (Johnson and Williams, 1993). Alternative mRNA splicing of the Ig loops in FGFR-1 through FGFR-3, leads to distinct functional variants of the receptor (Cancilla et al, 2001;Ornitz et al, 1996). FGF binding induces FGFR dimerization, which is followed by intermolecular transphosphorylation of the receptor subunits and the initiation of intracellular signal transduction cascades (Ornitz et al, 1996;Powers et al, 2000;Robinson et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

FGFR-1 signaling is involved in spermiogenesis and sperm capacitation

Cotton

Gibbs

Sanchez-Partida

et al. 2006

Journal of Cell Science

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Cloning of the fibroblast growth factor receptor (FGFR) adaptor Snt-2 cDNA and the identification of FGFR-1 protein in association with sperm tails, suggested that FGFR-1 signaling was involved in either sperm tail development or function. This hypothesis was tested by the creation of transgenic mice that specifically expressed a dominant-negative variant of FGFR-1 in male haploid germ cells. Mating of transgenic mice showed a significant reduction in pups per litter compared with wild-type littermates. Further analysis demonstrated that this subfertility was driven by a combination of reduced daily sperm output and a severely compromised ability of those sperm that were produced to undergo capacitation prior to fertilization. An analysis of key signal transduction proteins indicated that FGFR-1 is functional on wild-type sperm and probably signals via the phosphatidylinositol 3-kinase pathway. FGFR-1 activation also resulted in the downstream suppression of mitogen activated protein kinase signaling. These data demonstrate the FGFR-1 is required for quantitatively and qualitatively normal spermatogenesis and has a key role in the regulation of the global tyrosine phosphorylation events associated with sperm capacitation.

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Fibroblast growth factor receptors and their ligands in the adult rat kidney

Cited by 59 publications

References 50 publications

Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure

Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure

Angiogenesis and Fibroblast Growth Factors (FGFs) in a Three-Dimensional Collagen Gel Culture

FGFR-1 signaling is involved in spermiogenesis and sperm capacitation

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