Fibroblast Growth Factor Receptor 3 (FGFR3) modulates Paneth cell lineage allocation through a β‐catenin/Tcf‐4 dependent signaling mechanism

Brodrick, Brooks; Vidrich, Alda; Buzan, Jenny M.; Bradley, Leigh; Cohn, Steven M.

doi:10.1096/fasebj.23.1_supplement.359.1

Cited by 2 publications

(2 citation statements)

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“…PCs secrete antimicrobial peptides and proteins (AMPs), enzymes and growth factors, which form a biochemical barrier near the crypts, prevent bacterial invasion, and maintain stability of the intestinal environment (Brodrick et al, 2011;Gubatan et al, 2021;. These defense proteins are released into the intestinal lumen as "degranulation" by cytoplasmic granules at the top of PC (Ayabe et al, 2000).…”

Section: Pcs and Immune Regulationmentioning

confidence: 99%

Metabolic Modulation of Cellular Function

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Pcs and Immune Regulationmentioning

confidence: 99%

Metabolic Modulation of Cellular Function

2024

Frontiers Research Topics

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“…PCs secrete antimicrobial peptides and proteins (AMPs), enzymes and growth factors, which form a biochemical barrier near the crypts, prevent bacterial invasion, and maintain stability of the intestinal environment (Brodrick et al, 2011;Gubatan et al, 2021;He et al, 2022). These defense proteins are released into the intestinal lumen as "degranulation" by cytoplasmic granules at the top of PC (Ayabe et al, 2000).…”

Section: Pcs and Immune Regulationmentioning

confidence: 99%

Paneth cell development in the neonatal gut: pathway regulation, development, and relevance to necrotizing enterocolitis

Yang

Shi

2023

Front. Cell Dev. Biol.

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Paneth cells (PCs) are intestinal epithelial cells (IECs) that contain eosinophilic granules, which are located in Lieberkühn crypts. An increasing number of animal and human experiments have indicated that PCs are involved in the progression of a variety of intestinal as well as systemic inflammatory responses including necrotizing enterocolitis (NEC). NEC is an enteric acquired disease with high mortality that usually occurs in premature infants and neonates, however the underlying mechanisms remain unclear. In this review, we summarize the features of PCs, including their immune function, association with gut microbiota and intestinal stem cells, and their mechanism of regulating IEC death to explore the possible mechanisms by which PCs affect NEC.

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Fibroblast Growth Factor Receptor 3 (FGFR3) modulates Paneth cell lineage allocation through a β‐catenin/Tcf‐4 dependent signaling mechanism

Cited by 2 publications

References 1 publication

Metabolic Modulation of Cellular Function

Metabolic Modulation of Cellular Function

Paneth cell development in the neonatal gut: pathway regulation, development, and relevance to necrotizing enterocolitis

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