Fibroblast growth factor is stored in fiber extracellular matrix and plays a role in regulating muscle hypertrophy

Yamada, Shigeru; Buffinger, Nicholas; DiMario, Joseph X.; Strohman, Richard C.

doi:10.1249/00005768-198910001-00009

Cited by 80 publications

(39 citation statements)

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“…The detection of these fibers is based on their expression of embryonic andtor neonatal myosin (Yamada et al, 1989). In the present study, anti-BrdU positive cells, branched fibers (Fig.…”

Section: Number Of Branched Fibersmentioning

confidence: 51%

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Characteristics of compensatory hypertrophied muscle in the rat: I. Electron microscopic and immunohistochemical studies

et al. 1996

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“…The detection of these fibers is based on their expression of embryonic andtor neonatal myosin (Yamada et al, 1989). In the present study, anti-BrdU positive cells, branched fibers (Fig.…”

Section: Number Of Branched Fibersmentioning

confidence: 51%

“…New fiber formation in the compensatory model has been detected previously by several groups (Schiaffino et al, 1979;Salleo et al, 1980;Yamada et al, 1989). In the present study, we used immunohistochemical techniques to detect proliferating cells in the OP muscles using BrdU at each time interval.…”

Section: Number Of Branched Fibersmentioning

confidence: 52%

Characteristics of compensatory hypertrophied muscle in the rat: I. Electron microscopic and immunohistochemical studies

et al. 1996

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“…Continued proliferation of the cells may be supported by mitogens such as fibroblast growth factor (FGF) and insulin-like growth factor (IGF), which are up-regulated in muscle after injury (Jennische and Olivecrona, 1987;Jennische, 1989;Guthridge et al, 1992). Most satellite cells in regenerating muscle proliferate within empty sleeves of basal lamina from the degenerating myofibers and this material is thought to play several important roles as: (1) mechanical scaffolding (Vracko and Benditt, 19721, (2) a reservoir of growth factors (Yamada et al, 1989), and (3) a substratum of macromolecules favorable for myogenesis (Ocalan, et al, 1988;von der Mark and Ocalan, 1989). Finally, re-establishment of vascular and neural connections within the regenerating muscle is essential for normal growth and function (Grounds, 1991).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of skeletal muscle regeneration

Bischoff

Heintz

1994

Developmental Dynamics

161

103

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We have studied the effect of adding extra satellite cells or soluble factors from crushed muscle on regeneration of minced fragments from rat tibialis muscle. The muscle mince was wrapped in an artificial epimysium to prevent adhesions and cell immigration from adjacent muscles. Regeneration was quantitatively assessed by electrophoretic determination of the muscle-specific form of creatine kinase. Control minces exhibited three periods of change in creatine kinase activity during a 7-week regeneration period. Activity fell rapidly during the first week, then rose gradually from 1 3 weeks and increased more rapidly from 3-7 weeks. To augment the original complement of myogenic cells, satellite cells were isolated from the contralateral muscle, purified by density gradient centrifugation, and expanded in culture for 3 days before adding to the muscle mince. The added cells resulted in a 3-fold enhancement of creatine kinase activity throughout the regeneration period. Soluble muscle extract incorporated into a collagen matrix also stimulated regeneration when added to muscle mince. The extract accelerated the rate of creatine kinase increase during the 1 3 week period beyond that observed in the control or cell augmented mince, suggesting that factors in the extract may facilitate revascularization or reinnervation. The specific activity of creatine kinase was increased in regenerates augmented with both cells and extract, indicating that the effects enhance primarily myogenic processes.

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“…19 The myofiber extracellular matrix could provide a reservoir for these growth factors in muscle. 48 Moreover, other cell types participating in the degeneration-regeneration process and known to release different factors might activate satellite cells. Injured muscles are also infiltrated by inflammatory cells: neutrophils increase substantially in number at 1 to 6 h after a muscle lesion and then decline rapidly, whereas macrophages constitute the largest cell population at 12 h postinjury.…”

mentioning

confidence: 99%

Macrophages enhance muscle satellite cell proliferation and delay their differentiation

et al. 1999

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Fibroblast growth factor is stored in fiber extracellular matrix and plays a role in regulating muscle hypertrophy

Cited by 80 publications

References 0 publications

Characteristics of compensatory hypertrophied muscle in the rat: I. Electron microscopic and immunohistochemical studies

Characteristics of compensatory hypertrophied muscle in the rat: I. Electron microscopic and immunohistochemical studies

Enhancement of skeletal muscle regeneration

Macrophages enhance muscle satellite cell proliferation and delay their differentiation

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