Fibroblast growth factor-9 (glia-activating factor) stimulates proliferation and production of glial fibrillary acidic protein in human gliomas either in the presence or in the absence of the endogenous growth factor expression.

Miyagi, Naohisa; Kato, Seiya; Terasaki, Mizuhiko; Aoki, Takeshi; Sugita, Yasuo; Miki, Yoshio; Shigemori, Minoru; Morimatsu, Minoru

doi:10.3892/or.6.1.87

Cited by 14 publications

(18 citation statements)

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“…It is generally accepted that induction of peptide growth factor expression and/or transactivation of signaling pathways mediated by these growth factors is an important mechanism responsible for PGE 2 -induced cell proliferation. Fibroblast growth factor 9 is a potent mitogen for numerous cell types, including epithelium, stroma, neuronal cell, and chondrocytes (13,20,41,47), and plays important roles in the development of human diseases (13,18,26,41,47). In this report, we provide compelling evidence that PGE 2 directly induces FGF-9 expression and this action is parallel to its ability to stimulate estrogen biosynthesis.…”

Section: Discussionsupporting

confidence: 51%

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Prostaglandin E₂ Induces Fibroblast Growth Factor 9 via EP3-Dependent Protein Kinase Cδ and Elk-1 Signaling

Chuang

Sun

Chen

et al. 2006

Molecular and Cellular Biology

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Fibroblast growth factor 9 (FGF-9) is a potent mitogen that controls the proper development of many tissues and organs. In contrast, aberrant expression of FGF-9 also results in the evolution of many human diseases, such as cancers and endometriosis. Despite its vital function being reported, the cellular and molecular mechanisms responsible for the regulation of FGF-9 expression are mostly unknown. We report here that prostaglandin E 2 (PGE 2 ) induces expression of FGF-9, which promotes endometriotic stromal cell proliferation, through the EP3 receptor-activated protein kinase C␦ (PKC␦) signaling pathway. Activation of PKC␦ leads to phosphorylation of ERK1/2, and the transcription factor Elk-1 thereby promotes transcription of FGF-9. Two Elk-1 cis-binding sites located at nucleotides ؊1324 to ؊1329 and ؊1046 to ؊1051 of the human FGF-9 promoter are identified as crucial for mediating PGE 2 actions. Collectively, we demonstrate, for the first time, that PGE 2 can directly induce FGF-9 expression via a novel signaling pathway involving EP3, PKC␦, and a member of the ETS domain-containing transcription factor superfamily in primary human endometriotic stromal cells. Our findings may also provide a molecular framework for considering roles for PGE 2 in FGF-9-related embryonic development and/or human diseases.

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Section: Discussionsupporting

confidence: 51%

“…In addition, FGF-9 also plays pivotal roles in the development of human diseases, such as ovarian endometrioid adenocarcinomas, glioma, prostate cancer, and endometriosis (13,18,26,41,47). It was reported that FGF-9 can stimulate the proliferation of epithelial cells derived from ovarian endometrial carcinoma and prostate cancer (13,18).…”

mentioning

confidence: 99%

Prostaglandin E₂ Induces Fibroblast Growth Factor 9 via EP3-Dependent Protein Kinase Cδ and Elk-1 Signaling

Chuang

Sun

Chen

et al. 2006

Molecular and Cellular Biology

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“…If this is substantiated through experimental approaches, notwithstanding the fact that signaling genes are overrepresented in the mammalian genome, it would present a huge contribution to our understanding of the genetic mechanisms to environmental stressor adaptation. The MYH1, MYH3, MYH8, MYH10 and MYH13 genes on OAR11 have a direct role in energy metabolism that facilitates diverse functions including muscular contraction, cytokinesis and phagocytosis (Miyagi et al, 1999). The UGT8 (CHI6), GRIA1 (OAR5), PCDH9 (CHI12) and FGF11 (OAR11) genes are associated with the development and function of the nervous and endocrine systems (Monaghan et al, 1989;Barnard and Henley, 1990;Bosio et al, 1996;Smallwood et al, 1996;Halbleib and Nelson, 2006), while the BMP2 (OAR3), FGF2 (CHI17), FGF9 (CHI12, OAR10), GJB2 (CHI12), GJB6 (CHI12), GJA3 (CHI12, OAR12) and SPP1 (CHI6) genes encode proteins that influence body size, skeletal and embryonic development, and testicular embryogenesis (Abraham et al, 1986;Burgess and Maciag, 1989;Shimoyama et al, 1991;Ornitz et al, 1996;Ortega et al, 1998;Miyagi et al, 1999;Bandyopadyay et al, 2006).…”

Section: Functional Annotation Of the Candidate Genesmentioning

confidence: 99%

“…The MYH1, MYH3, MYH8, MYH10 and MYH13 genes on OAR11 have a direct role in energy metabolism that facilitates diverse functions including muscular contraction, cytokinesis and phagocytosis (Miyagi et al, 1999). The UGT8 (CHI6), GRIA1 (OAR5), PCDH9 (CHI12) and FGF11 (OAR11) genes are associated with the development and function of the nervous and endocrine systems (Monaghan et al, 1989;Barnard and Henley, 1990;Bosio et al, 1996;Smallwood et al, 1996;Halbleib and Nelson, 2006), while the BMP2 (OAR3), FGF2 (CHI17), FGF9 (CHI12, OAR10), GJB2 (CHI12), GJB6 (CHI12), GJA3 (CHI12, OAR12) and SPP1 (CHI6) genes encode proteins that influence body size, skeletal and embryonic development, and testicular embryogenesis (Abraham et al, 1986;Burgess and Maciag, 1989;Shimoyama et al, 1991;Ornitz et al, 1996;Ortega et al, 1998;Miyagi et al, 1999;Bandyopadyay et al, 2006). The BMP2 gene has also been reported to influence body size in cattle and sheep (Kijas et al, 2012;Xu et al, 2015) and the SPP1 gene was found to be located on a candidate region under selection in sheep (Lv et al, 2014), but the authors concluded that it had no role in the adaptation to climate-mediated selection pressure.…”

Section: Functional Annotation Of the Candidate Genesmentioning

confidence: 99%

Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment

et al. 2015

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Goats and sheep are versatile domesticates that have been integrated into diverse environments and production systems. Natural and artificial selection have shaped the variation in the two species, but natural selection has played the major role among indigenous flocks. To investigate signals of natural selection, we analyzed genotype data generated using the caprine and ovine 50K SNP BeadChips from Barki goats and sheep that are indigenous to a hot arid environment in Egypt's Coastal Zone of the Western Desert. We identify several candidate regions under selection that spanned 119 genes. A majority of the genes were involved in multiple signaling and signal transduction pathways in a wide variety of cellular and biochemical processes. In particular, selection signatures spanning several genes that directly or indirectly influenced traits for adaptation to hot arid environments, such as thermo-tolerance (melanogenesis) (FGF2, GNAI3, PLCB1), body size and development (BMP2, BMP4, GJA3, GJB2), energy and digestive metabolism (MYH, TRHDE, ALDH1A3), and nervous and autoimmune response (GRIA1, IL2, IL7, IL21, IL1R1) were identified. We also identified eight common candidate genes under selection in the two species and a shared selection signature that spanned a conserved syntenic segment to bovine chromosome 12 on caprine and ovine chromosomes 12 and 10, respectively, providing, most likely, the evidence for selection in a common environment in two different but closely related species. Our study highlights the importance of indigenous livestock as model organisms for investigating selection sweeps and genome-wide association mapping.

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“…Segundo a literatura, a atividade proliferativa celular pode ser influenciada por outros FGFs: FGF4 (Baczyk et al, 2005;Suzuki et al, 2001), FGF7 (Palmieri et al, 2003), FGF8 (Suzuki et al, 2001;Xu et al, 1998), FGF9 (Miyagi et al, 1999) e FGF10 (Xu et al, 1998 Mol. Cell.…”

Section: Resultsunclassified

Fator de crescimento fibroblástico básico e seus receptores em relação à atividade proliferativa na placenta bubalina em diferentes fases da gestação

Artoni

Moura

Barbosa

et al. 2007

Arq. Bras. Med. Vet. Zootec.

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Fibroblast growth factor-9 (glia-activating factor) stimulates proliferation and production of glial fibrillary acidic protein in human gliomas either in the presence or in the absence of the endogenous growth factor expression.

Cited by 14 publications

References 0 publications

Prostaglandin E₂ Induces Fibroblast Growth Factor 9 via EP3-Dependent Protein Kinase Cδ and Elk-1 Signaling

Prostaglandin E₂ Induces Fibroblast Growth Factor 9 via EP3-Dependent Protein Kinase Cδ and Elk-1 Signaling

Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment

Fator de crescimento fibroblástico básico e seus receptores em relação à atividade proliferativa na placenta bubalina em diferentes fases da gestação

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Fibroblast growth factor-9 (glia-activating factor) stimulates proliferation and production of glial fibrillary acidic protein in human gliomas either in the presence or in the absence of the endogenous growth factor expression.

Cited by 14 publications

References 0 publications

Prostaglandin E2 Induces Fibroblast Growth Factor 9 via EP3-Dependent Protein Kinase Cδ and Elk-1 Signaling

Prostaglandin E2 Induces Fibroblast Growth Factor 9 via EP3-Dependent Protein Kinase Cδ and Elk-1 Signaling

Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment

Fator de crescimento fibroblástico básico e seus receptores em relação à atividade proliferativa na placenta bubalina em diferentes fases da gestação

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Prostaglandin E₂ Induces Fibroblast Growth Factor 9 via EP3-Dependent Protein Kinase Cδ and Elk-1 Signaling

Prostaglandin E₂ Induces Fibroblast Growth Factor 9 via EP3-Dependent Protein Kinase Cδ and Elk-1 Signaling