Fibroblast growth factor 7 releasing particles enhance islet engraftment and improve metabolic control following islet transplantation in mice with diabetes

Abstract

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Considerations and challenges of islet transplantation and future therapies on the horizon

“…Modulation of the liver niche with growth factors [109] and anti-inflammatory agents [110] have been used with some success and polymer properties may be exploited to regulate release of such factors when islets are immediately transplanted and particularly vulnerable to apoptosis [109,111], but these are still at a very early pre-clinical stage. Accelerating the vascularisation of transplanted islets with a number of approaches including gene therapy methods [112] may be a relevant strategy to accelerate islet engraftment and may improve transplantation outcomes.…”

Paracrine Fibroblast Growth Factor-Based Therapy: An Unexpected Panacea for Metabolic-Dysfunction-Associated Fatty Liver Disease (MAFLD)

“…56 Alwahsh et al transplanted islets with FGF7-loaded galactosylated poly (DL-lactide-co-glycolic acid) particles into diabetic mice via the hepatic portal vein and found that these particles display a good safety profile and are able to induce short-term hepatocyte proliferation, enhance islet implantation, normalize blood glucose levels and improve liver damage. 57…”

“…56 Alwahsh et al transplanted islets with FGF7-loaded galactosylated poly (DLlactide-co-glycolic acid) particles into diabetic mice via the hepatic portal vein and found that these particles display a good safety profile and are able to induce short-term hepatocyte proliferation, enhance islet implantation, normalize blood glucose levels and improve liver damage. 57 FGF9: a contributing factor to MAFLD-HCC FGF9 is highly expressed in adipose tissue and moderately expressed in the liver. It promotes adipogenesis, aggravates inflammation, and promotes WAT development by inhibiting WAT browning.…”

Conditioning the liver into a favorable niche for pancreatic islet engraftment

“…In this issue of AJT, Alwahsh et al 5 present their innovate strategy to precondition the liver transplant site by creating a proliferative environment to subsequently enhance mouse syngeneic islet engraftment in order to improve long-term graft function.…”

“…In this issue of AJT , Alwahsh et al 5 present their innovate strategy to precondition the liver transplant site by creating a proliferative environment to subsequently enhance mouse syngeneic islet engraftment in order to improve long‐term graft function. To achieve liver tissue‐specific delivery of FGF, Alwahsh et al co‐transplanted syngeneic murine islets with FGF7 releasing galactosylated (GAL) poly(DL‐lactide‐co‐glycolic acid) particles.…”