Fibroblast Growth Factor 23 Is Increased in Calcium Nephrolithiasis with Hypophosphatemia and Renal Phosphate Leak

Rendina, Domenico; Mossetti, Giuseppe; Filippo, Gianpaolo De; Cioffi, Michele; Strazzullo, Pasquale

doi:10.1210/jc.2005-1606

Cited by 44 publications

(44 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reduced bone mass and high risk for osteoporotic fractures as a consequence of PTH and vitamin D abnormalities have also been documented in calcium stone formers [12,13,14,15], as well as a contributing role of FGF-23 and KLOTHO gene polymorphism in the pathogenesis of calcium nephrolithiasis [16,17]. Therefore, FGF-23 and KLOTHO are likely to influence the vitamin D status in this patient population.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status in Patients with Recurrent Kidney Stones

Pipili

Oreopoulos²

2013

Nephron Clin Pract

View full text Add to dashboard Cite

Data regarding the prevalence of 25-hydroxyvitamin D (25(OH)D) insufficiency in patients with nephrolithiasis, and the effects of vitamin D supplementation on parathyroid hormone (PTH) are few and conflicting. In this article, we examined the prevalence of vitamin D insufficiency and deficiency in 236 recurrent kidney stone formers and the correlation of vitamin D levels with other parameters of stone formation. The prevalent stone composition was calcium oxalate (80.4%) and uric acid (16.45%). One third of stone formers had vitamin D insufficiency and a quarter of them high PTH levels (PTH >7.5 pmol/l) with normal serum (total and ionized) calcium values. Predictor of high PTH was low 25(OH)D level (r = 0.989, r² = 0.977, p < 0.001). Stone formers with hypercalciuria had higher 25(OH)D values (72.26 ± 4.21 vs. 59.29 ± 1.76, p = 0.0013) compared to stone formers with urine calcium within normal ranges. Further studies are needed in order to better define the consequences of vitamin D insufficiency and to evaluate the impact of the therapeutic interventions in this cohort.

show abstract

Section: Discussionmentioning

confidence: 99%

Vitamin D Status in Patients with Recurrent Kidney Stones

Pipili

Oreopoulos²

2013

Nephron Clin Pract

View full text Add to dashboard Cite

show abstract

“…[68] Normal serum 1α,25(OH) 2D concentrations in the hypophosphatemic stone formers with hypercalciuria were unusual because most hypophosphatemic stone formers have elevated or high-normal serum 1α,25(OH) 2D concentrations. The role of FGF-23 in nephrolithiasis may be explored in future.…”

Section: Fgf-23 In Nephrolithiasismentioning

confidence: 99%

Renal phosphate handling: Physiology

Prasad

Bhadauria

2013

Indian J Endocr Metab

View full text Add to dashboard Cite

Phosphorus is a common anion. It plays an important role in energy generation. Renal phosphate handling is regulated by three organs parathyroid, kidney and bone through feedback loops. These counter regulatory loops also regulate intestinal absorption and thus maintain serum phosphorus concentration in physiologic range. The parathyroid hormone, vitamin D, Fibrogenic growth factor 23 (FGF23) and klotho coreceptor are the key regulators of phosphorus balance in body.

show abstract

“…Although increased serum levels of FGF-23 were found in hypophosphatemic nephrolithiasis patients (9), FGF-23 overexpression in cultured calvarias may suppress bone formation and matrix mineralization irrespective of the phosphate homeostasis (10). Serum 1,25-dihydroxyvitamin D [1,25(OH) 2 D 3 ] levels in IH patients are either normal or high (11)(12)(13)(14), and vitamin D receptor (VDR) polymorphism has been associated with hypercalciuria (15).…”

Section: Introductionmentioning

confidence: 99%

Expression of Fibroblast Growth Factor 23, Vitamin D Receptor, and Sclerostin in Bone Tissue from Hypercalciuric Stone Formers

Menon

Moysés

Gomes

et al. 2014

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background and objectives Increased bone resorption, low bone formation, and abnormal mineralization have been described in stone formers with idiopathic hypercalciuria. It has been previously shown that the receptor activator of NF-kB ligand mediates bone resorption in idiopathic hypercalciuria (IH). The present study aimed to determine the expression of fibroblast growth factor 23 (FGF-23), vitamin D receptor (VDR), and sclerostin in bone tissue from IH stone formers.Design, setting, participants, & measurements Immunohistochemical analysis was performed in undecalcified bone samples previously obtained for histomorphometry from 30 transiliac bone biopsies of idiopathic hypercalciuria stone-forming patients between 1992 and 2002 and 33 healthy individuals (controls). Serum parameters were obtained from their medical records.Results Histomorphometry disclosed 21 IH patients with high and 9 IH patients with normal bone resorption. Importantly, eroded surfaces (ES/BS) from IH patients but not controls were significantly correlated with VDR immunostaining in osteoblasts (r=0.51; P=0.004), sclerostin immunostaining in osteocytes (r=0.41; P=0.02), and serum 1,25-dihydroxyvitamin D (r=0.55; P,0.01). Of note, both VDR and sclerostin immunostaining were significantly correlated with serum 1,25-dihydroxyvitamin D in IH patients (r=0.52; P=0.01 and r=0.53; P=0.02, respectively), although VDR and sclerostin expression did not differ between IH and controls. IH patients with high bone resorption exhibited a significantly stronger sclerostin immunostaining than IH patients with normal bone resorption. FGF-23 expression in osteocytes from IH patients did not differ from controls and was not correlated with any histomorphometric parameter.Conclusions These findings suggest the contribution of VDR and sclerostin, as well as 1,25-dihydroxyvitamin D, to increase bone resorption in idiopathic hypercalciuria but do not implicate FGF-23 in the bone alterations seen in these patients.

show abstract

Fibroblast Growth Factor 23 Is Increased in Calcium Nephrolithiasis with Hypophosphatemia and Renal Phosphate Leak

Abstract: In our study population, renal phosphate leak affected 20% of stone formers and was strongly associated with increased serum FGF23 concentration.

Cited by 44 publications

References 17 publications

Vitamin D Status in Patients with Recurrent Kidney Stones

Vitamin D Status in Patients with Recurrent Kidney Stones

Renal phosphate handling: Physiology

Expression of Fibroblast Growth Factor 23, Vitamin D Receptor, and Sclerostin in Bone Tissue from Hypercalciuric Stone Formers

Contact Info

Product

Resources

About