Fibroblast Growth Factor 23 Expression in Human Calcified Vascular Tissues

Donate‐Correa, Javier; Mart&iacute;n-N&uacute;&ntilde;ez, Ernesto; Hern&aacute;ndez-Carballo, Carolina; Ferri, Carla; Tagua, V&iacute;ctor G.; Molinos, Alejandro Delgado; Castillo, &Aacute;ngel L&oacute;pez; Rodr&iacute;guez-Ramos, Sergio; Cerro-L&oacute;pez, Purificaci&oacute;n; L&oacute;pez-Tarruella, Victoria Castro; Felipe-Garc&iacute;a, Raquel; Ar&eacute;valo-Gonz&aacute;lez, Miguel A.; P&eacute;rez-Delgado, Nayra; Mora-Fern&aacute;ndez, Carmen; Navarro-Gonz&aacute;lez, Juan F.

doi:10.2139/ssrn.3335021

Cited by 3 publications

(2 citation statements)

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“…FGF23 levels did not differ according to an increase in calcification percentile severity. Although increased expression of FGF23 in human calcified tissue has been shown, 41 Scialla et al 42 described that FGF23 does not have a role in inducing arterial calcification. The opposite was found with sclerostin, a soluble Wnt pathway antagonist and a negative regulator of bone metabolism.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Mineral and Bone Disorders After Renal Transplantation

et al. 2022

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Original Clinical Science-General Background. Posttransplant mineral and bone diseases are causes of fractures, and their association with cardiovascular events is being studied. Methods. We analyzed the evolution of biochemical, histological, and imaging parameters pre-and 1 y post-renal transplantation in 69 patients and correlated mineral and bone findings with coronary calcifications. At inclusion and after 12 mo, clinical data and echocardiographic findings were recorded, and laboratory evaluations, radiography of the pelvis and hands, and bone biopsy were performed. Noncontrast cardiac computed tomography was performed during the second evaluation. Results. Serum levels of fibroblast growth factor 23 and sclerostin decreased in all patients, parathyroid hormone levels decreased in 89.8% of patients, bone alkaline phosphatase levels decreased in 68.1% of patients, and alpha-Klotho levels increased in 65.2% of patients. More than half of the patients presented with renal osteodystrophy at both biopsies, but histological findings improved: a significant transition from high to normal or low turnover and no significant differences in volume, mineralization defect, or cortical porosity at the 2 evaluations. Alpha-Klotho, sclerostin, and bone alkaline phosphatase shifts affect bone changes. Neither echocardiographic findings nor vascular calcification scores differed between the 2 points. Both the pretransplant period (dialysis vintage, sclerostin, and low bone volume at baseline) and the maintenance of abnormalities in the posttransplant period (high turnover posttransplant) were the most reliable predictors of the severity of the coronary calcification percentile. Conclusions. Renal transplantation improved bone and mineral abnormalities. The pretransplant period determines the severity of calcification. (Transplantation 2022;106: e251-e261).

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Section: Discussionmentioning

confidence: 99%

Improvement of Mineral and Bone Disorders After Renal Transplantation

et al. 2022

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“…Some animal studies have shown that RUNX2 expression is required for osteogenic phenotypic change in smooth muscle cells [21]. This transcription factor is also reportedly upregulated in human vascular fragments of large vascular territories where calcification is present [22]. However, evidence of osteogenesis is not a consistent finding across all studies of human VC.…”

Section: Discussionmentioning

confidence: 99%

Vascular calcification in skin and subcutaneous tissue in patients with chronic and end-stage kidney disease

et al. 2020

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Background: Vascular calcification (VC) is well described in large-and medium-sized vessels in patients with chronic kidney disease (CKD), especially in those with end-stage kidney disease (ESKD) on dialysis. Medial calcification is particularly prevalent in this population and contributes to arterial stiffness and increased cardiovascular mortality and morbidity. Apart from in the setting of calciphylaxis, few studies have assessed skin and subcutaneous calcification and associations with abnormalities of bone and mineral metabolism in patients with CKD. Methods: We performed a single-centre observational study to evaluate incisional skin tissue samples from three anatomical sites in patients with different stages of CKD undergoing elective surgery. We compared these samples to skin samples of a control cohort without CKD. Staining for calcification was performed with von Kossa method. A subgroup of skin samples were assessed by RT-PCR for upregulation of pro-calcific gene transcripts for tissue nonspecific alkaline phosphatase (TNAP) and Runt-related transcription factor 2 (RUNX2). Results: Forty-five patients were evaluated, 34 with CKD (including ESKD) and 11 control patients. VC was identified in 15 skin samples (13 CKD/ESKD and 2 controls). VC was present in the dermal and subcutaneous tissues of the neck, abdomen and arm samples. Two different histological types of VC were identified: speckled medial calcification and internal elastic lamina calcification. Presence of perieccrine calcification was identified in 14 samples, 10 with concurrent VC. There were no significant differences in serum parathyroid hormone, phosphate or calcium in patients with or without VC. Expression of TNAP or RUNX2 was not increased in samples from patients with ESKD or those with histological evidence of calcification. Conclusion: This study reports the novel finding of dermal and subcutaneous calcification in multiple anatomical locations in 38% of patients with advanced CKD/ESKD undergoing elective surgery but free from calciphylaxis.

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QR Codes in Education : A Review

Sondhi

Kumar

2022

IJSRST

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Mechanical advances carried utilizations of developments to schooling. Ordinary schooling progressively prospers with new advancements joined by more student dynamic conditions. In this continuum, there are students favoring self-learning. Customary learning materials yield alluring, spurring and innovatively improved learning materials. The QR (Quick Response) Codes are one of these advancements. The point of this review is to overhaul an illustration unit upheld with QR Codes and to get the student sees about the upgraded material. For this reason, the overhauled example unit was conveyed to 15 students in Balıkesir University in the scholastic year of 2013-2014. The students were approached to concentrate on the material. The students who had advanced mobile phones and Internet access were picked for the review. To give sectional variety, three gatherings were made. The gathering students were from Faculty of Education, Faculty of Science and Literature and Faculty of Engineering. Later the semi-organized meetings were held, the students were gotten some information about their pre-information about QR Codes, QR Codes' commitment to learning, hardships with utilizing QR Codes about and configuration issues. Spellbinding information examination was utilized in the review. The discoveries were deciphered based on Theory of Diffusion of Innovations and Theory of Uses and Gratifications. Later the exploration, the subjects found were attention to QR Code, kinds of QR Codes and applications, commitments to learning, and expansion of QR Codes. By and large, the students taking part in the review detailed that they knew about QR Codes; that they could utilize the QR Codes; and that involving QR Codes in schooling was valuable. They likewise communicated that such elements as visual components, allure and direct steering emphatically affected learning. What's more, they for the most part referenced that they didn't have any trouble utilizing QR Codes; that they enjoyed the plan; and that the substance ought to incorporate both shallow and inside and out data.

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Fibroblast Growth Factor 23 Expression in Human Calcified Vascular Tissues

Cited by 3 publications

References 0 publications

Improvement of Mineral and Bone Disorders After Renal Transplantation

Improvement of Mineral and Bone Disorders After Renal Transplantation

Vascular calcification in skin and subcutaneous tissue in patients with chronic and end-stage kidney disease

QR Codes in Education : A Review

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