Fibroblast growth factor 2 contributes to the effect of salidroside on dendritic and synaptic plasticity after cerebral ischemia/reperfusion injury

Li, Sisi; Lu, Ye-Chen; Ding, Daofang; Ma, Zhenzhen; Xing, Xiang‐Xin; Hua, Xu‐Yun; Xu, Jian‐Guang

doi:10.18632/aging.103308

Cited by 32 publications

(36 citation statements)

References 53 publications

(44 reference statements)

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“…In contrast, the microglia M2 phenotype promotes the secretion of anti-inflammatory cytokines, such as IL-4 and IL-10, thus alleviating neuroinflammation and improving neuronal survival (Schmieder et al, 2012). Li et al reported that the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in the brain tissue were significantly elevated in the rats with ischemic stroke (Li S. et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Effects of Exosomes on Neurological Function Recovery for Ischemic Stroke in Pre-clinical Studies: A Meta-analysis

Huang

Hong

Xiao

et al. 2020

Front. Cell. Neurosci.

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Background: Exosomes, especially stem cell-derived exosomes, have been widely studied in pre-clinical research of ischemic stroke. However, their pooled effects remain inconclusive.Methods: Relevant literature concerning the effects of exosomes on neurological performance in a rodent model of ischemic stroke was identified via searching electronic databases, including PubMed, Embase, and Web of Science. The primary outcomes included neurological function scores (NFS) and infarct volume (IV), and the secondary outcomes were several pro-inflammatory factors and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling-positive cells. Subgroup analyses regarding several factors potentially influencing the effects of exosomes on NFS and IV were also conducted.Results: We identified 21 experiments from 18 studies in the meta-analysis. Pooled analyses showed the positive and significant effects of exosomes on NFS (standardized mean difference −2.79; 95% confidence interval −3.81 to −1.76) and IV (standardized mean difference −3.16; 95% confidence interval −4.18 to −2.15). Our data revealed that the effects of exosomes on neurological outcomes in rodent stroke models might be related to routes of administration and exosomes sources. In addition, there was significant attenuation in pro-inflammatory factors, including interleukin-6, tumor necrosis factor-α and interleukin-1β, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling-positive cells when undergoing exosomes treatment.Conclusion: Cell-derived exosomes treatment demonstrated statistically significant improvements in structural and neurological function recovery in animal models of ischemic stroke. Our results also provide relatively robust evidence supporting cell-derived exosomes as a promising therapy to promote neurological recovery in stroke individuals.

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Section: Discussionmentioning

confidence: 99%

Effects of Exosomes on Neurological Function Recovery for Ischemic Stroke in Pre-clinical Studies: A Meta-analysis

Huang

Hong

Xiao

et al. 2020

Front. Cell. Neurosci.

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“…Salidroside exhibited neuroprotective effects against hypoxia/reperfusion injury by activating the SIRT1/FOXO3α pathway ( Xu, L. et al, 2018 ). In addition, salidroside is an effective treatment for ischemic stroke that functions via the fibroblast growth factor 2 (FGF2)-mediated cAMP/PKA/CREB pathway to promote dendritic and synaptic plasticity ( Li et al, 2020b ). Salidroside treatment reduced the expression of M1 microglia/macrophage markers and increased the exdslbpression of M2 microglia/macrophage markers after stroke and induced primary microglia from M1 phenotype to M2 phenotype ( Liu et al, 2018 ).…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review

Xie

et al. 2021

Front. Pharmacol.

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Natural products have a significant role in the prevention of disease and boosting of health in humans and animals. Stroke is a disease with high prevalence and incidence, the pathogenesis is a complex cascade reaction. In recent years, it’s reported that a vast number of natural products have demonstrated beneficial effects on stroke worldwide. Natural products have been discovered to modulate activities with multiple targets and signaling pathways to exert neuroprotection via direct or indirect effects on enzymes, such as kinases, regulatory receptors, and proteins. This review provides a comprehensive summary of the established pharmacological effects and multiple target mechanisms of natural products for cerebral ischemic injury in vitro and in vivo preclinical models, and their potential neuro-therapeutic applications. In addition, the biological activity of natural products is closely related to their structure, and the structure-activity relationship of most natural products in neuroprotection is lacking, which should be further explored in future. Overall, we stress on natural products for their role in neuroprotection, and this wide band of pharmacological or biological activities has made them suitable candidates for the treatment of stroke.

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“…Zhao et al has demonstrated that FGF2 possess neuroprotective effects through PI3K/Akt activation in a rodent stroke model Zhao et al (2016). A recent study on the mechanism underlying the effects of cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) on ischemic injury depends on regulating apoptosis and inflammation, and FGF2-mediated cAMP/PKA/cAMPresponse element binding protein (CREB) pathway to promote dendritic and synaptic plasticity (Li et al, 2020).…”

Section: Fgf2 In Strokementioning

confidence: 99%

Roles of Fibroblast Growth Factors and Their Therapeutic Potential in Treatment of Ischemic Stroke

et al. 2021

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Stroke is the leading cause of death worldwide, and its treatment remains a challenge. Complex pathological processes are involved in stroke, which causes a reduction in the supply of oxygen and energy to the brain that triggers subsequent cascade events, such as oxidative stress, inflammatory responses and apoptosis, resulting in brain injury. Stroke is a devastating disease for which there are few treatments, but physical rehabilitation can help improve stroke recovery. Although there are very few treatments for stroke patients, the discovery of fibroblast growth factors (FGFs) in mammals has led to the finding that FGFs can effectively treat stroke in animal models. As presented in this review, FGFs play essential roles by functioning as homeostatic factors and controlling cells and hormones involved in metabolism. They could be used as effective therapeutic agents for stroke. In this review, we will discuss the pharmacological actions of FGFs on multiple targets, including their ability to directly promote neuron survival, enhance angiogenesis, protect against blood-brain barrier (BBB) disruption, and regulate microglial modulation, in the treatment of ischemic stroke and their theoretical mechanisms and actions, as well as the therapeutic potential and limitations of FGFs for the clinical treatment of stroke.

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Fibroblast growth factor 2 contributes to the effect of salidroside on dendritic and synaptic plasticity after cerebral ischemia/reperfusion injury

Cited by 32 publications

References 53 publications

Effects of Exosomes on Neurological Function Recovery for Ischemic Stroke in Pre-clinical Studies: A Meta-analysis

Effects of Exosomes on Neurological Function Recovery for Ischemic Stroke in Pre-clinical Studies: A Meta-analysis

Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review

Roles of Fibroblast Growth Factors and Their Therapeutic Potential in Treatment of Ischemic Stroke

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