Fibroblast growth factor 2 can replace ectodermal signaling for feather development.

Song, Heekyung; Wang, Yuying; Goetinck, Paul F.

doi:10.1073/pnas.93.19.10246

Cited by 76 publications

(54 citation statements)

References 29 publications

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“…In particular, the scaleless mutant that exhibits a loss of function of the metatarsal epithelium to respond to dermal signals has played an important role in dissecting the inductive roles of early appendage formation (e.g., Goetinck and Abbott, 1963;Sengel and Abbott, 1963;Brotman, 1977b;McAleese and Sawyer, 1981). In conjunction with gene expression studies, scaleless has provided insights into how molecular mechanisms are linked to developmental events in the formation of feathers and scales (e.g., Shames et al, 1991;Zeltinger and Sawyer, 1992;Song et al, 1994Song et al, , 1996Vaillet et al, 1998;Widelitz et al, 2000). There are several chicken breeds that exhibit extensive feather formation along the shank and digits (e.g., Bantams, Cochins, and Silkies) that also provide useful models for study of the initial induction of epidermal organs of chick.…”

Section: Introductionmentioning

confidence: 99%

Bmp7 mediates early signaling events during induction of chick epidermal organs

Harris

Linkhart²,

Fallon³

2004

Developmental Dynamics

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The induction and specification of a large number of vertebrate organs require reciprocal signaling between an epithelium and subjacent mesenchyme. In the formation of integumentary organs, the initial inductive signaling events leading to the formation of the organ primordia stem from the mesenchyme. However, the epithelium must have the capacity to respond to these signals. We demonstrate that bone morphogenetic protein 7 (Bmp7) is an early molecular marker for epidermal organ development during development of feathers and scales of the chick. Bmp7 is expressed broadly in the preplacode epidermis and subsequently becomes localized to the forming placodes of feathers and scales. An examination of Bmp7 expression in the scaleless mutant chicken integument indicates that Bmp7 expression in the epidermis is associated with the ability to form epidermal organs. We show that BMP7 function is necessary for the formation of epidermal placodes in both feather and scale forming epidermis. In addition, precocious expression of Bmp7 in the metatarsal epidermis of the Silkie mutant or treatment of the metatarsus with ectopic BMP7 protein results in feather development from scale forming integument. From these data, we propose that Bmp7 is necessary and sufficient, in a developmental context, to mediate the competence of an epithelium to respond to inductive signals from the underlying mesenchyme to form epidermal organs in the chick. We propose that regulation of Bmp7 in localized areas of the embryonic epidermis facilitates the development of regional formation of integumentary organs. Developmental Dynamics 231:22-32, 2004.

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Section: Introductionmentioning

confidence: 99%

Bmp7 mediates early signaling events during induction of chick epidermal organs

Harris

Linkhart²,

Fallon³

2004

Developmental Dynamics

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“…We found a premature stop codon predicted to lead to loss of function in the gene encoding fibroblast growth factor 20 (FGF20) that is unique to the scaleless line (Wells et al, 2012). The FGF family was previously known to be important for feather development, making a molecule of this class a good candidate for the scaleless mutation (Song et al, 1996). These molecular genetic studies identifying specific DNA alterations in Naked neck and scaleless lines can be informative for introgression of these traits into production lines, but they do not yet constitute a systems biology approach, focussing as they do on simple Mendelian traits rather than interactive processes.…”

Section: Introductionmentioning

confidence: 99%

Systems biology and livestock production

Headon

2013

Animal

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The mapping of complete sets of genes, transcripts and proteins from many organisms has prompted the development of new '-omic' technologies for collecting and analysing very large amounts of data. Now that the tools to generate and interrogate such complete data sets are widely used, much of the focus of biological research has begun to turn towards understanding systems as a whole, rather than studying their components in isolation. This very broadly defined systems approach is being deployed across a range of problems and scales of organisation, including many aspects of the animal sciences. Here I review selected examples of this systems approach as applied to poultry and livestock production, product quality and welfare.

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“…An inductive signal from the dermis initiates formation of epidermal placodes that, in turn, induce dermal condensation in the underlying dermis (reviewed in Sengel,1976). Several molecules that mediate inductive signaling during hair and feather tract formation have been identified, including Wnts Noramly et al, 1999;Huelsken et al, 2001;Andl et al, 2002), bone morphogenetic protein (BMP) in early skin development (Scaal et al, 2002), BMP inhibitor at placode stages (Patel et al, 1999), fibroblast growth factors (FGFs) Song et al, 1996), Hedgehog and Notch/Delta families (Crowe et al, 1998;Viallet et al, 1998). Notch/Delta signals refine the patterning of the feather placode (Crowe et al, 1998).…”

Section: Abstract: Hex Homeobox Gene Feather Placode Wnt Feathermentioning

confidence: 99%

Expression of Hex during feather bud development

Obinata

Akimoto²

2005

Int. J. Dev. Biol.

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We studied proline-rich divergent homeobox gene Hex/Prh expression in the dorsal skin of chick embryo during feather bud development. Hex mRNA expression was first observed in the dorsolateral ectoderm and mesenchyme at 5 days, then in the epithelium and the dermis of the dorsal skin before placode (primordium of feather bud) formation and then was restricted to the placode and the dermis under the placode. Afterward, Hex expression was seen in the epidermis and the dermis of the posterior region of short bud. In accordance with Hex mRNA expression in the placode, Hex protein was observed in the epidermis as well as in the dermis of the placode. Immunoelectron microscopic study indicated that the protein located both in the nuclei and cytoplasm of the epidermis and the dermis at the short bud stage. The Wnt signaling pathway plays an essential role in the early inductive events in hair (Wnt3a and 7a) and feather (Wnt7a) follicles. The pattern of Hex expression in the epidermis was similar to that of Wnt7a, while little, if any, expression of Wnt7a was detected in the dermis under the placode or the dermis of the short bud compared with that of Hex, suggesting that Hex plays an important role in the initiation of feather morphogenesis.

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Fibroblast growth factor 2 can replace ectodermal signaling for feather development.

Cited by 76 publications

References 29 publications

Bmp7 mediates early signaling events during induction of chick epidermal organs

Bmp7 mediates early signaling events during induction of chick epidermal organs

Systems biology and livestock production

Expression of Hex during feather bud development

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