Fibroblast growth factor-2 and its receptor expression in proliferating precursor cells of the subventricular zone in the adult rat brain

Frinchi, Monica; Bonomo, Alessandra; Salinaro, Angela Trovato; Condorelli, D. F.; Fuxé, Kjell; Spampinato, Marcello G.; Mudò, Giuseppa

doi:10.1016/j.neulet.2008.09.059

Cited by 52 publications

(42 citation statements)

References 20 publications

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“…FGF-2 is a potent neurogenic factor promoting early neurogenesis, supporting proliferation of neural stem cells and progenitors and enhancing the survival of mature neurons. [69][70][71][72] Moreover, a reduction in FGF-2 expression and an increase in FGF receptor expression in the frontal cortex and hippocampus were observed in post-mortem human brain samples of patients suffering from major depression. 73,74 Similarly, animal models further support the role of the FGF system in depression and its potential involvement in antidepressant treatment.…”

Section: Discussionmentioning

confidence: 91%

Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior

et al. 2009

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Adult bone marrow-derived mesenchymal stem cells (MSCs) are regarded as potential candidates for treatment of neurodegenerative disorders, because of their ability to promote neurogenesis. MSCs promote neurogenesis by differentiating into neural lineages as well as by expressing neurotrophic factors that enhance the survival and differentiation of neural progenitor cells. Depression has been associated with impaired neurogenesis in the hippocampus and dentate gyrus. Therefore, the aim of this study was to analyze the therapeutic potential of MSCs in the Flinders sensitive line (FSL), a rat animal model for depression. Rats received an intracerebroventricular injection of culture-expanded and 1,1 0 -dioctadecyl-3,3,3 0 ,3 0 -tetramethylindocarbocyanine perchlorate (DiI)-labeled bone marrow-derived MSCs (10 5 cells). MSC-transplanted FSL rats showed significant improvement in their behavioral performance, as measured by the forced swim test and the dominant-submissive relationship (DSR) paradigm. After transplantation, MSCs migrated mainly to the ipsilateral dentate gyrus, CA1 and CA3 regions of the hippocampus, and to a lesser extent to the thalamus, hypothalamus, cortex and contralateral hippocampus. Neurogenesis was increased in the ipsilateral dentate gyrus and hippocampus of engrafted rats (granular cell layer) and was correlated with MSC engraftment and behavioral performance. We therefore postulate that MSCs may serve as a novel modality for treating depressive disorders.

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Section: Discussionmentioning

confidence: 91%

Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior

et al. 2009

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“…The roles of FGFR1 have been found in aspects of neurogenesis, [45] memory consolidation, [14] and affective disorders. [13] However, in the current MA, the central FGFR1 RNA levels were significantly higher in patients with MDD.…”

Section: Discussionmentioning

confidence: 99%

Significantly higher peripheral fibroblast growth factor-2 levels in patients with major depressive disorder

Wu¹,

Tseng²,

Chen

et al. 2016

Medicine

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“…FGFR-1, FGFR-2 and FGFR-3 are initially expressed in ventral regions of the ventricular zone [18]. By in situ hybridization and immunohistochemistry, FGFR-1 and FGFR-2 were described in dividing SVZ neural progenitors, whereas FGFR-3 was only found by non-proliferative SVZ cells [15]. Similar findings have been described in along the RMS in migratory neuronal precursors [44].…”

Section: Fgfr Expression In Neural Stem Cellmentioning

confidence: 71%

“…In the central nervous system (CNS), FGF2 is produced by glial cells [13] and binds to four different types of receptors: FGFR-1, FGFR-2, FGFR-3 y FGFR-4 [14]. Interestingly, FGFRs are differentially expressed in the neural progenitors of the SGZ and the SVZ [15]. The role of FGFR subtypes in these neurogenic regions and adult progenitor cells is still unclear [16].…”

Section: Introductionmentioning

confidence: 99%

Role of Fibroblast Growth Factor Receptors in Astrocytic Stem Cells

Galvez‐Contreras¹,

González-Castañeda²,

Luquı́n³

et al. 2012

CST

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There are two well-defined neurogenic regions in the adult brain, the subventricular zone (SVZ) lining the lateral wall of the lateral ventricles and, the subgranular zone (SGZ) in the dentate gyrus at the hippocampus. Within these neurogenic regions, there are neural stem cells with astrocytic characteristics, which actively respond to the basic fibroblast growth factor (bFGF, FGF2 or FGF-β) by increasing their proliferation, survival and differentiation, both in vivo and in vitro. FGF2 binds to fibroblast growth factor receptors 1 to 4 (FGFR1, FGFR2, FGFR3, FGFR4). Interestingly, these receptors are differentially expressed in neurogenic progenitors. During development, FGFR-1 and FGFR-2 drive oligodendrocytes and motor neuron specification. In particular, FGFR-1 determines oligodendroglial and neuronal cell fate, whereas FGFR-2 is related to oligodendrocyte specification. In the adult SVZ, FGF-2 promotes oligodendrogliogenesis and myelination. FGF-2 deficient mice show a reduction in the number of new neurons in the SGZ, which suggests that FGFR-1 is important for neuronal cell fate in the adult hippocampus. In human brain, FGF-2 appears to be an important component in the anti-depressive effect of drugs. In summary, FGF2 is an important modulator of the cell fate of neural precursor and, promotes oligodendrogenesis. In this review, we describe the expression pattern of FGFR2 and its role in neural precursors derived from the SVZ and the SGZ.

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Fibroblast growth factor-2 and its receptor expression in proliferating precursor cells of the subventricular zone in the adult rat brain

Cited by 52 publications

References 20 publications

Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior

Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior

Significantly higher peripheral fibroblast growth factor-2 levels in patients with major depressive disorder

Role of Fibroblast Growth Factor Receptors in Astrocytic Stem Cells

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