Fibroblast encapsulation in hybrid silica–collagen hydrogels

Desimone, Martín Federico; Hélary, Christophe; Mosser, Gervaise; Giraud‐Guille, Marie‐Madeleine; Livage, Jacques; Coradin, Thibaud

doi:10.1039/b921572g

Cited by 69 publications

(74 citation statements)

References 33 publications

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“…In parallel, the addition of polymers, either natural or synthetic, or of inorganic particles was also studied but most of these works were performed on acellularized systems [11][12][13]. Recently, we have shown that hybrid materials made from collagen and silicates were efficient in decreasing gel contraction and enhancing cell proliferation in the short term [14]. However, in the longer term, reorganization of the collagen network and rapid silica dissolution occurred, to the detriment of cell activity.…”

Section: Introductionmentioning

confidence: 96%

Silica–collagen bionanocomposites as three-dimensional scaffolds for fibroblast immobilization

Desimone¹,

Hélary²,

Rietveld³

et al. 2010

Acta Biomaterialia

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100

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Section: Introductionmentioning

confidence: 96%

Silica–collagen bionanocomposites as three-dimensional scaffolds for fibroblast immobilization

Desimone¹,

Hélary²,

Rietveld³

et al. 2010

Acta Biomaterialia

Self Cite

100

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“…215,223 Within the scope of bone regeneration, silica-based biohybrid materials involving structural proteins are promising materials for application as implants, according to the good properties of biocompatibility and non-cytotoxicity. 224 An additional advantage of these biohybrids is their bioactivity, a property related to the ability to induce the formation of HAP after soaking in a simulated body fluid (SBF), which is beneficial for the further attachment and proliferation of cells constituting the new tissue. This property has been achieved in different silica-protein hybrids and points out to a possible synergistic effect of silica and collagen on the material bioactivity, since those components alone were not able to promote the formation of apatite.…”

Section: Structural Proteins-based Silica and Silicate Biohybridsmentioning

confidence: 99%

Hybrid and biohybrid silicate based materials: molecular vs. block-assembling bottom–up processes

2011

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“…There are numerous similar examples including covalent binding of antibodies for functioning of sol-gel films (Fig. 7.7) [135][136][137][138][139][140][141].…”

Section: Biomedical Nanocompositesmentioning

confidence: 97%

Bionanocomposites Assembled by “From Bottom to Top” Method

Pomogailo

Джардималиева

2014

Nanostructured Materials Preparation via Condensation Ways

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Particles, which take part in different biological processes, have a special place in nanometer composites. Rich and variable biochemistry of proteins displays key importance of a nanometer phenomenon for a working mechanism of living organisms [1,2], and this provides a wide range of possibilities for development of new types of hybrid nanomaterials with constructible structures, functions and shapes [3][4][5].Integration of nanoparticles and biomolecules, each having unique properties, on the one hand, and being in the same nanometer scale (enzymes, antigens, and antibodies of typical sizes 2-20 nm like nanoparticles), on the other hand, as of two structurally compatible classes of materials, gives resultant new hybrid nanomaterials with synergetic properties and functions (Fig. 7.1).Interaction of nanoparticles with biopolymers (proteins, nucleic acids, polysaccharides) plays very important role in enzyme catalysis, biosorption, biohydrometallurgy, geobiotechnology, etc.). There is a great interest to nanomaterials, which can be used in biomedical and pharmaceutical applications due to their biocompatibility and biodegradation. At the same time bionanocomposites should meet some demands to plasticity of a matrix, they should have improved barrier, antimicrobial properties, ability to controlled release of bioactive substances such as antimicrobial agents, antioxidants, drugs, calcium compounds in biologically available form and their mixtures, etc. Biopolymers, such as natural and synthetic proteins, obtained by chemical methods or by genetic modification of microorganisms or plants, nucleic acids (including synthetic ones), biodegraded complex polyethers, such as polylactic acid, and its derivatives, oligo-hydroxyalkanoate, most often, polyhydroxybutyrate, their copolymers, biomedical materials, such as hydroxyapatites, are used. There is an interesting group of materials for this purpose including synthetic and natural (vegetable and animal) polysaccharides, such as cellulose and its derivatives, alginates, dextranes, acacia gum, chitosan, and any of its natural and synthetic derivatives, especially chitosan acetate, and proteins obtained from raw animal materials, as well as proteins from maize (especially zein) or soya, gluten derivatives, gelatin, casein, etc. Relatively widely used in

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Fibroblast encapsulation in hybrid silica–collagen hydrogels

Abstract: Silica-collagen scaffolds are synthesized by the simultaneous polymerization of aqueous silicates and self-assembly of protein triple helices in the presence of living human dermal fibroblasts.

Cited by 69 publications

References 33 publications

Silica–collagen bionanocomposites as three-dimensional scaffolds for fibroblast immobilization

Silica–collagen bionanocomposites as three-dimensional scaffolds for fibroblast immobilization

Hybrid and biohybrid silicate based materials: molecular vs. block-assembling bottom–up processes

Bionanocomposites Assembled by “From Bottom to Top” Method

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