Fibroblast Chalone and Serum Mitogen (Anti-chalone)

Houck, J. C.; Sharma, V. K.; Richard, Sharma; Cheng, Richard F.

doi:10.1038/newbio246111a0

Cited by 18 publications

(4 citation statements)

References 5 publications

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“…Bullough and Laurence, 1960). Recently, "chalone" was purified and its kinetics have been studied (Houck et al, 1972(Houck et al, , 1973. Cell contact may alter membrane conformation making it susceptible to "chalone".…”

Section: Discussionmentioning

confidence: 99%

Cell contact-dependent ganglioside changes in mouse 3T3 fibroblasts and a suppressed sialidase activity on cell contact

Yogeeswaran¹,

Hakomori²

1975

Biochemistry

100

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Certain enzyme activities for synthesis and degradation of gangliosides and the chemical quantity and incorporation of radioactivity from [14C] galactose into gangliosides have been studied in 3T3 cells and their transformed counterparts at various cell population densities. The chemical quantity of and the incorporation of radioactivity into GD1a ganglioside increased at the early stage of cell contact ("contact response" of ganglisoide), whereas response was not detectable in transformed 3T3 cells at any stage of cell contact. These phenomena were reproduced in five separate qualitative analyses and two quantitative determinations of gangliosides. As the basis of these phenomena, a membrane-bound sialidase activity which acted on gangliosides was suppressed in 3T3 cells at the "touching" stage of cell-to-cell contact. Transformed cells did not display the change of sialidase activity at any stage of cell contact.

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Section: Discussionmentioning

confidence: 99%

Cell contact-dependent ganglioside changes in mouse 3T3 fibroblasts and a suppressed sialidase activity on cell contact

Yogeeswaran¹,

Hakomori²

1975

Biochemistry

100

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“…'Chalone' activity has also been described in preparations from a variety of other tissues and cell types, including lymphocytes (Moorhead et al, 1970), granulocytes (Rytomaa & Kiviniemi 1968), fibroblasts (Houck, Sharma & Cheng, 1973), lung parenchyma (Simnett, Fisher & Heppleston, 1969) and kidney (Simnett & Chopra, 1969). Even antichalones have been proposed (Elgjo& Edgehill, 1973).…”

Section: Is Epidermal Homeostasis a Necessity?comments On Epidermal Gmentioning

confidence: 99%

Is epidermal homeostasis a necessity?—comments on epidermal growth control

Marks

1980

Br J Dermatol

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“…To discriminate between the two possibilities, a different kind of experiment is needed. The inhibitor (or 'chalone') hypothesis is supported by a number of recent observations on several tissues [3][4][5] including the kidney [6,7], and it remains unexplained why it was not considered in the paper of Lyons et at. [I], After the latter had been submitted, more arguments were reported by Dicker and Morris [8].)…”

mentioning

confidence: 63%

Letters to the Editor

1976

Nephron

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Fibroblast Chalone and Serum Mitogen (Anti-chalone)

Cited by 18 publications

References 5 publications

Cell contact-dependent ganglioside changes in mouse 3T3 fibroblasts and a suppressed sialidase activity on cell contact

Cell contact-dependent ganglioside changes in mouse 3T3 fibroblasts and a suppressed sialidase activity on cell contact

Is epidermal homeostasis a necessity?—comments on epidermal growth control

Letters to the Editor

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