Fibro-osseous pseudotumor of the digits

Dupree, William B.; Enzinger, Franz M.

doi:10.1002/1097-0142(19861101)58:9<2103::aid-cncr2820580923>3.0.co;2-c

Cited by 146 publications

(147 citation statements)

References 13 publications

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“…Healed fibular strut graft donor site Unfortunately plain radiographs demonstrating periosteal reaction, cortical erosions, and calcifications do not always aid in the diagnostic challenge as these features vary. [1][2][3]7] Spjut and Dorfman noted an agressive periosteal reaction noted on radiographs thereby naming it FRP.…”

Section: Discussionmentioning

confidence: 99%

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The diagnostic conundrum of Florid Reactive Periostitis: A case report and review of the literature

Goldman¹,

Frankenhoff

2016

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We report on a case of digital benign fibroblastic proliferative lesion that aggressively recurred after multiple excisions and showed histologic progression from a Fibrosseous Pseudotumor (FOPT) to Florid Reactive Periostitis (FRP). We recommend caution on incisional biopsies that do not excise the lesion fully based on the clinical course, radiographic, and histologic findings. Our case demonstrates the protean nature of this entity and the difficulty in obtaining an accurate diagnosis based on the clinical course and radiographic and histologic findings.

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Section: Discussionmentioning

confidence: 99%

“…[7] Other names, including nodular fasciitis [8] and parosteal fasciitis [9] have been commonly used to describe the same entity. MRI findings can be consistent with parosteal osteosarcoma, thereby further confusing the clinical picture.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic conundrum of Florid Reactive Periostitis: A case report and review of the literature

Goldman¹,

Frankenhoff

2016

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“…19 Fibro-osseous pseudotumors of the digits not only frequently contain cellular cartilaginous tissue but also exhibit a nodular fasciitis-like myofibroblastic component and woven bone production in various stages of maturation. [1][2][3] Tumoral calcinosis, which may on occasion involve Figure 2 The lesions typically arose in a subepidermal location (a) and showed a deep dermal/subcutaneous accumulation of basophilic ground substance with increased amount of wiry collagen (b). More heavily collagenized areas contained an increased number of bland fibroblastic cells (c).…”

Section: Discussionmentioning

confidence: 99%

“…Chondroid matrix may be seen in benign and malignant soft-tissue tumors (eg, chondromas and chondrosarcomas), as well as in reactive, nonneoplastic processes, such as the variously named pseudosarcomatous osteocartilaginous proliferations of the digits [1][2][3] and tumoral calcinosis. 4 The clinical significance and treatment of these different chondroid lesions varies greatly, and their correct classification is important.…”

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confidence: 99%

Myxochondroid metaplasia of the plantar foot: a distinctive pseudoneoplastic lesion resembling nuchal fibrocartilaginous pseudotumor and the equine digital cushion

Shon

Folpe

2013

Modern Pathology

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Cartilaginous tumors of soft tissue are uncommon, with benign chondromas of soft parts greatly outnumbering rare soft-tissue chondrosarcomas. Over the past several years, we have seen in consultation a distinctive, benign-appearing chondroid soft-tissue lesion of the plantar foot that differs in a number of respects from chondroma of soft parts. Herein we report our experience with this distinctive lesion. A retrospective review of all cases from the foot in our soft-tissue consultation and institutional surgical pathology archives identified 9 similar cases, most often previously coded as 'fibroconnective tissue with chondroid metaplasia'. Six cases were submitted in consultation due to concern for a neoplastic process, in particular chondroma of soft parts or fibro-osseous pseudotumor of the digits. The patients were 4 young males (age range 8-16 years, mean 11.5 years) and 5 older patients, including 4 women and 1 man (age range 34-78 years, mean 56.4 years). All cases occurred in the subcutaneous plantar soft tissues of the feet, including four cases confined to the toes, and presented as non-specific, variably painful masses. Radiographic studies, available in six cases, did not show any evidence of bone involvement. Histologically, the lesions were characterized by a partially circumscribed, variably cellular proliferation of bland fibroblastic cells in a fibromyxoid background in areas showing distinct stromal basophilia and a chondroid appearance. Small foci of true cartilaginous metaplasia with lacuna formation were occasionally seen. Cartilaginous differentiation was confirmed in three cases with immunohistochemistry for S100 and ERG proteins. Intralesional cystic change was common, as were a variety of other reactive-appearing changes in the surrounding connective tissue. Characteristic morphological features of chondroma of soft parts and/or fibro-osseous pseudotumor of the digits were absent. Clinical follow-up (7 patients, 2-115 months, median 38 months) showed all patients to be without recurrent disease. We have identified a morphologically distinctive lesion of the foot that appears to represent a reactive, metaplastic process, presumably secondary to chronic mechanical stress. The morphological features of myxochondroid metaplasia of the plantar foot are reminiscent of those of nuchal fibrocartilaginous pseudotumor and the equine digital cushion, further suggesting a reactive/reparative etiology. Awareness of the unique features of this lesion should allow its ready distinction from other neoplastic and pseudoneoplastic (osteo) cartilaginous lesions of the feet.

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“…The clinical differential may include exostosis, and in unusual, ulcerated cases, more exotic possibilities may be considered. [16][17][18] Cut surface is red-tan and has gritty calcifications, unlike the other fibrous tumors in this category. The microscopic appearance is of a subcutaneous, multinodular, fibroblastic proliferation arranged in short, haphazard fascicles merging with irregular spicules of woven bone (Figure 4).…”

Section: Fibroma Of Tendon Sheathmentioning

confidence: 99%

Acral manifestations of soft tissue tumors

Paral

Petronic‐Rosic

2017

Clinics in Dermatology

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This group of biologically diverse entities is united by topographic localization to the hands and feet. Categorizing tumors by body site narrows the differential into a short list of possibilities that can facilitate accurate and rapid diagnosis. The goal of this review is to provide a practical approach to soft tissue tumors of acral locations for clinicians, pathologists, and researchers alike. What ensues in the following text is that tight coupling of the clinical picture and histopathologic findings should produce the correct diagnosis, or at least an abbreviated differential. The salient clinicopathologic, immunohistochemical, and molecular features are presented alongside current treatment recommendations for each entity.

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Fibro-osseous pseudotumor of the digits

Cited by 146 publications

References 13 publications

The diagnostic conundrum of Florid Reactive Periostitis: A case report and review of the literature

The diagnostic conundrum of Florid Reactive Periostitis: A case report and review of the literature

Myxochondroid metaplasia of the plantar foot: a distinctive pseudoneoplastic lesion resembling nuchal fibrocartilaginous pseudotumor and the equine digital cushion

Acral manifestations of soft tissue tumors

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