Fibrinolytic system in normotensive subjects and hypertensive patients

Armas-Hernández, María José; Hernández-Hernández, Rafael; Pacheco, Beatriz; Sosa-Canache, Beatriz; Cammarata, Rosalba; Carvajal, Atiff R.; Armas-Padilla, M C; Guerrero, Jaime

doi:10.1016/j.amjhyper.2004.03.160

Cited by 2 publications

(3 citation statements)

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“…[14–19] A comparative cross-sectional study has also supported this finding showed that hypertensive patients tended to have an unbalanced fibrinolytic system and tendency towards a hypercoagulability and a more frequently thrombotic complications compared to normotensive subjects. [13] Finding of high fibrin D-DI in patients with HTN suggests hypercoagulable state and ongoing intravascular fibrin formation (and possibly early thrombus formation) that plays a role in the pathogenesis of cardiovascular diseases and complications of HTN. However, this finding was conflicting with another study done in Sudan and a study by Sechi et al who showed that the D-DI level was insignificantly increased in hypertensive patients when compared with healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…Commonly observed in hypertensive patients, the hypercoagulable state appears to act as an important risk factor for thrombotic complications and may play a role in disease progression. [13] Among the degradation products resulting from the proteolytic actions of plasmin on fibrin, D-dimer is the smallest fibrin degradation byproduct, exhibiting unique characteristics. D-DI can be used to estimate the state of activation of the coagulation system, which is elevated by increasing fibrin formation and fibrinolysis.…”

Section: Discussionmentioning

confidence: 99%

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Plasma D-dimer levels are correlated with disease severity among hypertensive patients: A comparative cross-sectional study

Long

Zhang

et al. 2022

Medicine

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It has been reported that inappropriate acute thrombus formation is the pathophysiological substrate underlying increased risk and severity of target organ damage in hypertension (HTN). However, the relationship between severity of HTN and D-dimer has not been well characterized. The study was aimed to assess plasma D-dimer level and its correlation with disease severity among hypertensives. A comparative cross-sectional study was conducted at Wuhan Asia Heart Hospital among 100 participants (60 hypertensives and 40 controls). The correlation between variables were determined using correlation coefficients, regression analysis, and also using different parametric and nonparametric tests. We observed higher D-dimer levels among hypertensives compared to the healthy controls (P < .001). The D-dimer levels were found to be increased significantly with the severity of HTN (P < .001). D-dimer was found to have a diagnostic power of 86.9% in differentiating complicated from uncomplicated HTN at 0.83 mg/L cutoff value. This study suggests that D-dimer level was higher among hypertensives than control groups and it was also increasing significantly with the severity of HTN. This suggests that hypercoagulability of fibrin plays a role in the occurrence of thromboembolic complications of hypertensive patients.Abbreviations: AUC = area under the curve, BMI = body mass index, BP = blood pressure, CHD = coronary heart disease, CI = confidence interval, CVD = cardiovascular disease, DBP = diastolic blood pressure, D-DI = D-dimer, HTN = hypertension, PAD = peripheral arterial disease, ROC = receiver operating characteristic, SBP = systolic blood pressure, TOD = target organ damage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasma D-dimer levels are correlated with disease severity among hypertensive patients: A comparative cross-sectional study

Long

Zhang

et al. 2022

Medicine

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“…108 There is accumulating evidence implicating PAI-1 in the development of hypertension, 109 and plasma PAI-1 is associated with several risk factors for hypertension, including obesity, 110,111 insulin resistance, 111,112 and inflammation. 113 Studies reveal a direct correlation between plasma PAI-1 and hypertension as well as its associated conditions, [114][115][116][117][118][119][120] namely, arterial stiffness 121 and atherosclerosis. 122 Interestingly, the 4G allele for PAI-1 is associated with increased systolic, diastolic, and mean arterial blood pressure, 123 disclosing a direct link between plasma PAI-1 and blood pressure.…”

Section: Pai-1 As a Biomarker For Obesity Diabetes And Metabolic Synd...mentioning

confidence: 99%

Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)

Morrow

Mutch

2022

Semin Thromb Hemost

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Plasminogen activator inhibitor 1 (PAI-1), a SERPIN inhibitor, is primarily known for its regulation of fibrinolysis. However, it is now known that this inhibitor functions and contributes to many (patho)physiological processes including inflammation, wound healing, cell adhesion, and tumor progression.This review discusses the past, present, and future roles of PAI-1, with a particular focus on the discovery of this inhibitor in the 1970s and subsequent characterization in health and disease. Throughout the past few decades diverse functions of this serpin have unraveled and it is now considered an important player in many disease processes. PAI-1 is expressed by numerous cell types, including megakaryocytes and platelets, adipocytes, endothelial cells, hepatocytes, and smooth muscle cells. In the circulation PAI-1 exists in two pools, within plasma itself and in platelet α-granules. Platelet PAI-1 is secreted following activation with retention of the inhibitor on the activated platelet membrane. Furthermore, these anucleate cells contain PAI-1 messenger ribonucleic acid to allow de novo synthesis.Outside of the traditional role of PAI-1 in fibrinolysis, this serpin has also been identified to play important roles in metabolic syndrome, obesity, diabetes, and most recently, acute respiratory distress syndrome, including coronavirus disease 2019 disease. This review highlights the complexity of PAI-1 and the requirement to ascertain a better understanding on how this complex serpin functions in (patho)physiological processes.

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Fibrinolytic system in normotensive subjects and hypertensive patients

Cited by 2 publications

References 0 publications

Plasma D-dimer levels are correlated with disease severity among hypertensive patients: A comparative cross-sectional study

Plasma D-dimer levels are correlated with disease severity among hypertensive patients: A comparative cross-sectional study

Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)

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