Fibrinolytic Parameters in Spermatozoas and Seminal Plasma

Maier, Ulrich; Kirchheimer, Johannes C.; Hienert, G; Christ, Günter; Binder, Bernd R.

doi:10.1016/s0022-5347(17)37958-2

Cited by 19 publications

(24 citation statements)

References 12 publications

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“…Two types of PA proteins have been identified in mammals based on biochemical, immunological and functional properties: (1) t-PA, which is synthesized by a large number of tissues and plays a major role in regulating intravascular fibrinolysis, and (2) u-PA, which was first identified in human urine and later in various tissues; the latter is involved mainly in the degradation of extracellular matrix proteins associated with cell migration and tissue remodelling phenomena (Dano et al., 1985). The presence of different PAS as well as fibrinolytic inhibitors has been shown in seminal plasma and/or spermatozoa from man and animals (Smokovitis et al, 1987;Huarte et al, 1987;Maier et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Plasminogen activator activity and fertilizing ability of human spermatozoa

et al. 1993

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Mature spermatozoa contain a number of proteases that are supposed to contribute to their fertilizing ability. The present study was directed at plasminogen activator (PA), a protease that belongs to the group of serine proteases and converts the zymogen plasminogen to the active broad-spectrum protease plasmin. To investigate the possible role of PA in the fertilization process, we have measured sperm-bound PA activity in 63 patients included in an in-vitro fertilization (IVF) programme and assessed their relationship to standard semen parameters and the rate of fertilization. PA activity was correlated significantly with the sperm count, as well as with sperm motility and morphology. Using logistic regression analysis, specific PA (pmol pNA 10(-6) cells min-2) was found to significantly influence the probability of fertilization. Other significantly predictive factors were motility and the percentage of spermatozoa with normal morphology. The sperm concentration (10(6) cells ml-1) did not significantly affect the outcome of IVF. We suggest that sperm-bound PA is involved in the fertilization process and may represent a potential indicator of sperm fertilizing capacity.

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Section: Discussionmentioning

confidence: 99%

Plasminogen activator activity and fertilizing ability of human spermatozoa

et al. 1993

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“…Maier et al observed significantly higher t-PA concentrations in the spermatozoa of patients with oligoasthenoteratozoospermia (OAT syndrome) than in normozoospermic men (34). Moreover, t-PA concentrations in the ejaculate were also significantly higher compared to u-PA, and the t-PA and u-PA concentrations in the ejaculate were comparable between normozoospermic and oligozoospermic men (34).…”

Section: Male Study Populationmentioning

confidence: 98%

Possible role of the plasminogen activation system in human subfertility

Ebisch

Steegers‐Theunissen

Sweep

et al. 2007

Fertility and Sterility

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“…Very recently the presence of high tissue plasminogen activator antigen has been reported again by Maier et al (10) both in spermatozoa and in seminal plasma. Little is known about the role of tissue plasminogen activator activity.…”

Section: Discussionmentioning

confidence: 72%

Coagulation and Fibrinolysis Markers in Seminal Plasma of Patients under Evaluation for Involuntary Childlessness

Wersch¹,

Vries-Hanje²,

Ubachs³

1992

Clinical Chemistry and Laboratory Medicine

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Semen specimens from four groups of patients were evaluated for coagulation and fibrinolysis factors: a group of patients with infertile semen and involuntary childlessness (n = 35), a group with fertile semen and involuntary childlessness (n = 39), a group with fertile semen and proven fertility before vasectomy (n = 34) and a group with infertile semen after vasectomy (n = 147).The third patient group with proven fertility before vasectomy was considered as a control group. Only small amounts of fibrinogen, factor VIII:c, plasminogen, antithrombin III, fibrin monomers and plasminogen activator inhibitor-1 were detected in seminal plasma. The thrombin-antithrombin HI, D-dimer and tissue plasminogen activator regular concentrations were measured and the D-dimer/thrombin-antithrombin III ratios calculated. The reference ranges were assessed and the quantities were compared in the different patient groups. Significant differences were demonstrated between the prevasectomy group (= control group) and both the postvasectomy and the infertility groups with respect to D-dimer and D-dimer/thrombin-antithrombin III ratio. We conclude that both coagulation and fibrinolysis play a part in coagulum formation and liquefaction of seminal plasma. The balance between coagulation and fibrinolysis (expressed as D-dimer/ thrombin-antithrombin III ratio) was significantly different between the control group and the three patient groups. The coagulation/fibrinolysis balance was impaired in the semen from post vasectomy patients and from those with involuntary childlessness and the D-dimer/thrombin-antithrombin HI -ratios in both these patient groups were very similar.

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Fibrinolytic Parameters in Spermatozoas and Seminal Plasma

Cited by 19 publications

References 12 publications

Plasminogen activator activity and fertilizing ability of human spermatozoa

Plasminogen activator activity and fertilizing ability of human spermatozoa

Possible role of the plasminogen activation system in human subfertility

Coagulation and Fibrinolysis Markers in Seminal Plasma of Patients under Evaluation for Involuntary Childlessness

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