Fibrinolytic markers and vasodilatory capacity following acute exercise among men of differing training status

Baynard, Tracy; Jacobs, Helena M.; Kessler, Craig M.; Kanaley, Jill A.; Fernhall, Bo

doi:10.1007/s00421-007-0534-4

Cited by 19 publications

(9 citation statements)

References 52 publications

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“…3). Although previous studies, focused on blood flow response to RH, have not paid attention to baseline blood flow [5,22,[29][30][31][32][33][34], we should emphasize that the increased RH in the COMBO group may be partly associated with an increase in baseline blood flow. The increase in baseline blood flow and RH may be induced by angiogenesis, muscular hypertrophy and improvements of endothelial and autonomic functions [5,35,36], but further study is warranted to clarify the mechanisms.…”

Section: Discussionmentioning

confidence: 83%

Effect of combined resistance and aerobic training on reactive hyperemia in men

et al. 2009

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Reduced response to reactive hyperemia (RH) in the extremities reflects impaired endothelium-dependent vasodilation of the microvasculature. The aims of the present study were to determine whether resistance training and a combination of aerobic and resistance training increase the endothelial vasodilation of the forearm assessed by RH. A total of 39 young men were assigned to either high-intensity resistance training (HIR; six types of exercises, 80% 1RM x 10 repetitions x 3 sets, n = 14) or moderate-intensity resistance training (MIR; six types of exercises, 50% 1RM x 16 repetitions x 3 sets, n = 14) or a combination of high-intensity resistance training and moderate-intensity endurance training (COMBO; HIR and 60% maximal heart rate x 30 min, n = 11) groups. We measured forearm blood flow response to RH before and after 4 months of exercise intervention. All training groups increased maximal strength in all muscle groups tested (all P < 0.05). After 4 months of training, the forearm blood flow during RH increased significantly in the MIR and COMBO groups, from 57 +/- 4 to 66 +/- 7 ml/min per 100 ml tissue and from 59 +/- 6 to 74 +/- 8 ml/min per 100 ml tissue, respectively (both P < 0.05). There was no change in the response to RH in the HIR groups. In conclusion, the findings in this study demonstrate that combined resistance and aerobic training may affect the vasoreactivity response to RH in the forearm, but not resistance training alone.

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Section: Discussionmentioning

confidence: 83%

Effect of combined resistance and aerobic training on reactive hyperemia in men

et al. 2009

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“…These results confirm the present findings and indicate that PAI-1 inhibits fibrinolysis in vivo. It suggests also that delivering PAI-1 to a forming thrombus is an important physiological mechanism for subsequent thrombus stabilization [47][48][49][50][51]. One obstacle in using wPAI-1 as a clinically useful haemostatic drug is its short half-life (2 h) [52,53].…”

Section: Discussionmentioning

confidence: 99%

Very long half‐life plasminogen activator inhibitor type 1 reduces bleeding in a mouse model

et al. 2010

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OBJECTIVE To investigate the potential for the future clinical use of a very long half‐life plasminogen activator inhibitor type 1 (VLHL PAI‐1) as a haemostatic agent. MATERIALS AND METHODS We developed a VLHL PAI‐1 (half‐life >700 h) recombinant mutant of PAI‐1 and assessed VLHL PAI‐1 for its ability to inhibit fibrinolysis in vitro using human, rabbit, mouse and rat blood. Fibrin clot lysis time, monitored by thromboelastometry, was determined at various concentrations of VLHL PAI‐1. Also, we determined total bleeding time and total blood loss of control, VLHL PAI‐1‐, tissue‐type plasminogen activator (tPA)‐ and tPA + VLHL PAI‐1‐treated mice. RESULTS Using a thromboelastometer, mouse blood was most similar to human blood in its coagulation and fibrinolytic characteristics. We evaluated the affect of VLHL PAI‐1 on haemostasis using the mouse model and showed that VLHL PAI‐1 is an effective inhibitor of fibrin clot degradation. It reduced time of bleeding and total blood loss. CONCLUSION VLHL PAI‐1 may provide an important physiological mechanism to protect clots from premature dissolution in surgical and trauma settings.

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“…28 Nagelkirk et al, 29 observed that in healthy women, AREX (6 sets of 10 leg extension repetitions at 70% e 1 MR) increased fibrinolytic stimulation; however, there was no change in PAI-1 activity. Further, Baynard et al 30 examined the effect of different physical activity patterns on fibrinolysis and vasodilatory capacity using a cross-sectional design with endurance-trained, resistance-trained, and untrained men. The authors found that the trained subjects demonstrated anti-atherogenic profile, showing lower PAI-1 levels than the sedentary group.…”

Section: Discussionmentioning

confidence: 99%

Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men

et al. 2014

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Background & aim: Dyslipidemia is involved with in development of cardiovascular diseases and obesity, exercise is recommended as a successful intervention. Dietary L-arginine (L-arg) supplementation may improve in lipid metabolism. However, these combined strategies on lipid profile were not tested yet. This study examines the effects of short term of L-arg supplementation and acute resistance exercise (AREX) on the blood lipid profile and inflammatory proteins in overweight men. Methods: Seven overweight men, 46 AE 5 yrs, body weight 93.1 AE 12.0 Kg and BMI 31.7 AE 3 kg/m 2 , participated in a randomized, double-blind and crossover study, distributed into exercise groups, based on the supplementation (6 g/day of placebo or Arginine for 7 days). Supplementation periods were separated by 7-days of wash-out. The AREX was comprised of eight exercises, with an exercise intensity of 60% 1RM. The glucose, lipid profile (NEFA, triglycerides, HDL cholesterol, LDL cholesterol and total cholesterol) and inflammatory proteins [plasminogen activator inhibitor-1 (PAI-1) and adiponectin] were determined at rest, immediately, after exercise and 1 h after exercise sessions. Results: Triglycerides, total cholesterol, and adiponectin levels not showed time-dependent changes under the different conditions. LDL cholesterol and NEFA levels decreased after 1 h recovery periods when compared to rest periods only in L-arg supplementation group (P < 0.05). PAI-1 was reduced and HDL cholesterol exhibits increases immediately after AREX and 1 h recovery periods when compared with rest periods in both groups (P < 0.05). Conclusion: These results indicate that L-arg supplementation can potentiate the effects of exercise inducing changes in the LDL cholesterol and NEFA levels.

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Fibrinolytic markers and vasodilatory capacity following acute exercise among men of differing training status

Cited by 19 publications

References 52 publications

Effect of combined resistance and aerobic training on reactive hyperemia in men

Effect of combined resistance and aerobic training on reactive hyperemia in men

Very long half‐life plasminogen activator inhibitor type 1 reduces bleeding in a mouse model

Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men

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