Fibrinolytic drugs prevent pericardial adhesions in the rabbit

Wiseman, David M.; Kamp, L.; Linsky, C. B.; Jochen, R.F.; Pang, Roy H. L.; Scholz, PM

doi:10.1016/0022-4804(92)90062-5

Cited by 38 publications

(19 citation statements)

References 29 publications

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“…It is probable that serosal injury, bleeding and fibrin deposition in the abdominal cavity, together with reduced fibrinolytic activity, are the main causative factors. Postoperative adhesions may have severe clinical consequences, including intestinal obstruction, chronic pelvic pain and infertility 1 , the treatment of which significantly increases healthcare costs 2 .…”

Section: Introductionmentioning

confidence: 99%

Effect of antiadhesive agents on peritoneal carcinomatosis in an experimental model

Pucciarelli

Codello

Rosato

et al. 2002

British Journal of Surgery

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Section: Introductionmentioning

confidence: 99%

Effect of antiadhesive agents on peritoneal carcinomatosis in an experimental model

Pucciarelli

Codello

Rosato

et al. 2002

British Journal of Surgery

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“…Subsequently, normal pericardial mesothelial cell growth is observed on the surfaces free of adhesions. [1] Therefore, the basic methods studied to prevent adhesions include fibrinolytic agents, [2] anti-inflammatory agents, [3,4] permanent physical barriers which involve pericardial closure either directly or using an ePTFE membrane as a substitute [5,6] and resorbable barriers to prevent early fibrin deposition [7][8][9][10][11][12][13][14][15][16][17] N-acetyl cysteine have been also shown to reduce adhesions probably through fibroblast inhibition, since it is in liquid form the ideal method of application is still undetermined. [21] The closure of pericardium has been used as a barrier method to decrease the adhesions.…”

Section: Discussionmentioning

confidence: 99%

“…[1] Among these methods, fibrinolytic agents have caused serious postoperative bleeding in the initial trials [2] and were not, therefore, further studied. Although anti-inflammatory agents have been shown to be effective in the experimental studies, [3,4] their potential for systemic side effects is an important drawback for their widespread use.…”

mentioning

confidence: 99%

Combined use of barrier methods to prevent pericardial adhesions: Is it always better?

Korun¹

2017

Turk Gogus Kalp Dama

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ÖZAmaç: Bu çalışmada bir tavşan modeli üzerinde perikard kapatılması, genişletilmiş politetrafloroetilen (ePTFE) membran ve rezorbe edilebilen adezyon bariyerinin (REPEL-CV ® ) kombine ya da ayrı ayrı kullanımının perikardiyal adezyonlar üzerine etkileri araştırıldı.Ça lış mapla nı:Otuz tavşan altı gruba randomize edildi: kontrol, perikard, genişletilmiş politetrafloroetilen, rezorbe edilebilen membran, genişletilmiş politetrafloroetilen + rezorbe edilebilen membran ve perikard + rezorbe edilebilen membran. Ameliyat sonrası beşinci haftada yapışıklıkların yoğunluğu kalitatif bir derecelendirme sistemi kullanılarak değerlendirildi ve histolojik örnekler incelendi. Bul gu lar:Rezorbe edilebilen membran grubunun tenasite skorları kontrol, perikard ve genişletilmiş politetrafloroetilen gruplarına kıyasla, anlamlı düzeyde düşük bulundu (p<0.01). Genişletilmiş politetrafloroetilen + rezorbe edilebilen membran ve perikard + rezorbe edilebilen membran gruplarının skorları, kontrol grubuna kıyasla, daha düşük bulundu (sırasıyla p<0.05 ve p<0.01). Rezorbe edilebilen membranın kombine kullanımında, tek başına kullanımına kıyasla, skorlarda anlamlı farklılık saptanmadı. Makroskopik olarak rezorbe edilebilen membran grubunda sternotomi sonrası perikard üzerinde parmak ile kolayca diseke edilebilir ince yapışıklıklar vardı. Genişletilmiş politetrafloroetilen + rezorbe edilebilen membran ve perikard + rezorbe edilebilen membran gruplarında sternum altında da yapışıklıklar izlendi.So nuç:Rezorbe edilebilen membran tek başına ya da genişletilmiş politetrafloroetilen membran veya perikard kapatılması ile kombine olarak kullanıldığında, perikardiyal adezyonları azaltmada etkiliydi. Genişletilmiş politetrafloroetilen membran ve perikardium kapanması substernal fibrozisi artırdığından, rezorbe edilebilen membranın kombine kullanımından ziyade tek başına kullanımı tercih edilebilir.Anah tar söz cük ler: Biyouyumlu malzemeler; tekrar ameliyat; cerrahi adezyonlar. ABSTRACTBackground: This study aims to investigate the effects of combined and individual use of pericardial closure, expanded polytetrafluoroethylene membrane and resorbable adhesion barrier (REPEL-CV

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“…On the other hand, it was demonstrated that systemic anti-inflammatory drugs and topical fibrinolytic agents reduce adhesion. However, both approaches impair wound healing and unfavorably influence bleeding [7]. Inflammatory response is important in the pathogenesis of adhesion formation.…”

Section: Discussionmentioning

confidence: 99%

Could the Material Wrapped Around the Heart Prevent Adhesion? A Case Report

2015

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Adhesions around the heart might enhance the difficulty in performing the second heart surgery. These fibrin adhesions between epicardium and pericardium increase not only the cost, but also bleeding, duration of surgery and poor clinical outcomes. A patient, who had undergone mitral commissurotomy with the assistance of heart-lung machine (CPB) in 1998 and in whom a material that was considered to reduce adhesion had been wrapped around the heart, underwent cardiac re-surgery in 2014. No detailed information could be obtained about film barrier performed during the first surgery from the center where the surgery was performed. In our clinic, we observed the effect of the material wrapped around the heart during mitral valve replacement on adhesion.

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Fibrinolytic drugs prevent pericardial adhesions in the rabbit

Cited by 38 publications

References 29 publications

Effect of antiadhesive agents on peritoneal carcinomatosis in an experimental model

Effect of antiadhesive agents on peritoneal carcinomatosis in an experimental model

Combined use of barrier methods to prevent pericardial adhesions: Is it always better?

Could the Material Wrapped Around the Heart Prevent Adhesion? A Case Report

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