Fibrinolytic activity is not dependent upon exercise mode in post-myocardial infarction patients

Abstract

In this study we investigated possible differences in fibrinolytic activity in cardiac patients while they performed treadmill and cycle ergometry. Thirteen post-myocardial infarction patients completed two maximal exercise tests on treadmill and cycle ergometers. Blood was collected before and after each exercise test and was analyzed for the fibrinolytic variables, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activity, and lactate. Maximal oxygen uptake, heart rate, and ventilation were greater (P < 0.05) on the treadmill than during cycle ergometry, however, blood lactate was similar between modes. t-PA activity significantly increased with exercise (P < 0.05) and there was a trend toward a reduction in PAI-1 activity with exercise, but this did not reach statistical significance. The fibrinolytic responses to maximal exercise did not differ between the two modes of exercise studied. Therefore, exercise intensity, but not the mode of exercise, appeared to be the primary determinant of the fibrinolytic response to acute exercise in these patients.

PAI-1, the Plasminogen System, and Skeletal Muscle

“…Furthermore, PAI-1 levels tend to be elevated even in healthy sedentary individuals [ 43 ]. A strong body of evidence has demonstrated the acute anti-fibrotic response following exercise [ 44 , 45 , 46 , 47 , 48 , 49 ]. Not only does exercise normalize PAI-1 levels in healthy subjects, but also in diseased populations [ 50 , 51 , 52 , 53 ].…”

“…Indeed, several studies have identified the importance of plasminogen system function but have yet to fully elucidate a role for PAI-1 in skeletal muscle [ 35 , 36 , 37 , 38 , 39 , 40 ], although recent evidence suggests that skeletal muscle is also a site of PAI-1 synthesis [ 29 , 41 , 42 ]. Control of PAI-1 levels in the circulation is of clinical importance and while studies generally indicate that circulating PAI-1 can be controlled with exercise [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ] or through the administration of pharmacological PAI-1 inhibitors [ 17 , 22 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ]. This review will summarize the biology of PAI-1 and the plasminogen system as it relates to overall tissue function and ECM remodeling, highlight the role of PAI-1 in skeletal muscle, and shed light on potential therapeutic strategies to reduce or normalize PAI-1 levels in an attempt to improve muscle and overall health.…”

Acute and subacute effects of strenuous exercise on platelet aggregation, coagulation and fibrinolysis in patients with stable coronary artery disease

“…Several studies have reported an increased fibrinolytic response following strenuous exercise in patients with CAD with decreased PAI-1 [35][36][37][38][39][40] and increased t-PA [35][36][37][38][39]41,42]. Three studies included a group with healthy controls, and all results were similar to the CAD group [37,38,40].…”

Άσκηση Και Αιμορρεολογικές Παράμετροι Σε Φυσιολογικά Άτομα

“…Οι Fernhall και συν. 148 υπέβαλαν σε οξεία μέγιστη ισοτονική ή/και ισομετρική σωματική κόπωση άτομα που είχαν υποστεί καρδιαγγειακό επεισόδιο. Οι ερευνητές αυτοί διαπίστωσαν ότι, αμέσως μετά το πέρας της προσπάθειας η δραστηριότητα του t-PA στο αίμα αυξήθηκε και εκείνη του PAI-1 παρουσίασε τάσεις μείωσης.…”