Fibrinolytic Activity in Plasma of Newborn Infants

Changes in Plasma Fibrinolytic Activity of Newborn Infants during First Hour after Birth

“…It i\as even ohservcd that the fibrinolytic activity \\ a\ rn~ore 1)ronouriced if the in oitro incubation \\a\ lmformed a t a lower pH (6.3) tlian a t a higher pH (7.1). Also in a similar invcstigation (in patients suffcring from liver cirrhosis) increased fihrinolytie activity nt n loicpr pH \$as observed, explnrlied I)y the authors as possibly due to an enhanced activation of plasminogen to plaimin a t a lower pH than a t a higlier one [4].The differences in fibrinolytic activity bet\\ ccn the single individuals in our previoiisly presented investigation [ 8 ] may he caused by blood sampling a t different points of time during the first hour after hirth. Rerglund [3] has shomn that the fibrinolytic activity of plasma disappears coinpletely during the first three d a j s after hirth a i d it is possible that the diminution is considerable already n ithiri tlw first hour.In order to evaluate h o \ 4 fast the &minution in fihrinolytic activity is during the first hour after birth folloir ing invest1g-nt ion as performed.…”

Enzyme replacement therapy for mucopolysaccharidosis VI: evaluation of long‐term pulmonary function in patients treated with recombinant human N‐acetylgalactosamine 4‐sulfatase

“…The MVV maneuver of rapid respiration is thought to replicate maximal ventilation during exercise (Stein et al 2003). Although MVV is generally well correlated with FEV1 (Fulton et al 1995; Stein et al 2003), a disproportionate decrease in MVV relative to FEV1 has been reported in neuromuscular disorders (Serisier et al 1982; Braun et al 1983) and upper airway obstruction (Engstroem et al 1964), and therefore, improvement in these areas with ERT may contribute to the earlier response on the MVV assessment.…”

Fibrinolytic Tissue Activity in the Urogenital Tract and the Adrenal Gland of Human Embryos and New‐born

“…The high activity in the fetal urinary tract might be related to the occurrence of the plasminogen activator urokinase in urine from human fetuses and new-born (22) in spite of the high glomerular filtration rate and small power of reabsorption in the fetal kidney (26). If the production of urokinase is based upon the content of tissue activator in the kidney and involved in the general fibrinolytic activity in blood (10, 12, 15, 17, 29) the large activity in fetal renal parenchyme may contribute to the spontaneous fibrinolytic activity and very small plasminogen content in blood from especially immature but also mature infants as compared to adults (3,9,11,13,14,16,20,30,32).…”