Fibrinolysis in Citrated and Oxalated Blood

Menon, I. S.

doi:10.1016/s0140-6736(67)92529-9

Cited by 19 publications

(10 citation statements)

References 3 publications

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“…Fibrinolytic activity was measured by the euglobulin lysis time (ELT) which was estimated by the method of von Kaulla (1963) modified by Menon (1967). The investigations were carried out at a constant time, the patients resting and fasting before the test was performed.…”

Section: Methodsmentioning

confidence: 99%

Effects of changes in temperature (local and central) on plasma fibrinolytic activity

Dodman¹,

Cunliffe²,

Roberts³

et al. 1973

J Clin Pathol

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SYNOPSISThe effect of local and whole-body heating and cooling on plasma fibrinolytic activity has been investigated in 59 subjects. An increase in whole-body temperature and both local cooling and heating increased the fibrinolytic activity. The results demonstrate that the application of local heat or cold will produce a local increase in fibrinolytic activity which is independent of general factors such as emotion and stress.Much is known about the physiological factors which influence blood fibrinolytic mechanisms, for example, exercise (Biggs, MacFarlane, and Pilling, 1947;Fearnley and Lackner, 1955) and emotion (MacFarlane, 1947;Ogston, McDonald, and Fullerton, 1962) increase fibrinolytic activity whereas increasing weight reduces fibrinolytic activity (Grace, 1967). In view of our interest in cutaneous vascular disorders and their possible precipitation by a cold environment, eg, Raynaud's phenomenon, we looked further into the effects of temperature on plasma fibrinolysis. In support of this investigation was the observation by Cunliffe and Menon (1969) that infusions of low molecular weight dextran have beneficial effects on the clinical state and blood fibrinolytic activity in patients with Raynaud's phenomenon. Subjects and MethodsThe investigation consisted of exposing 59 volunteers, 34 females and 25 males aged 17-47 years, to local and whole body heat and cold and measuring the blood fibrinolytic activity before and after exposure. Fibrinolytic activity was measured by the euglobulin lysis time (ELT) which was estimated by the method of von Kaulla (1963) modified by Menon (1967). The investigations were carried out at a constant time, the patients resting and fasting before the test was performed.Central temperature was measured orally and the skin temperature was measured by a thermister (Brighton Laboratories) placed on the skin. Twenty other subjects placed one arm up to the elbow in a water bath at 4°C for four minutes, the appropriate arm remaining at room temperature and acting as a control. A mean decrease in skin temperature of 11-5 degrees was produced in the immersed arm. There was no decrease in general body temperature.In 32 subjects the effect of heat was investigated: 18 of these subjects had a hot bath (45°C) for 10 minutes the subjects lying immersed in the bath up to the neck. This produced a significant increase in central body temperature of 2 1°C. Fourteen patients placed one arm in a water bath at 45°C for four minutes; this produced an increase in local skin temperature of 6 8°C in the immersed arm but in nopatient was there anyrise in body temperature.Blood was taken immediately before and immediately after the experiment in all subjects; wherever possible blood was taken from both arms before and after the investigation. ResultsThere was a significant (p < 0-01) increase in fibrinolytic activity after exposure to generalized heat ( fig. 1) but not (p < 0 1) after exposure to generalized cold ( fig. 2). Localized heat produced a significant increase (p < 0-01) in fibrinol...

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Section: Methodsmentioning

confidence: 99%

Effects of changes in temperature (local and central) on plasma fibrinolytic activity

Dodman¹,

Cunliffe²,

Roberts³

et al. 1973

J Clin Pathol

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show abstract

“…Fibrinolytic activity of the plasma was assessed by the euglobulin lysis time, which was estimated by the method of von Kaulla (1963) as modified by Menon (1967) using an automatic euglobulin clot-lysis recorder (Carmanen Instruments Ltd.). The F.R.-antigen titre was measured by the tanned red cell haemagglutination inhibition technique of Merskey et al, (1966).…”

Section: Methodsmentioning

confidence: 99%

Clinical and Laboratory Double-blind Investigation on Effect of Fibrinolytic Therapy in Patients with Cutaneous Vasculitis

Dodman¹,

Cunliffe²,

Roberts³

et al. 1973

BMJ

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“…The euglobulin-lysis time, which was chosen for its value as a measure of plasminogen activator content, was estimated in duplicate by von K a u l l a ' s meth od [5] slightly modified as previously described [6]. The fibrinolytic activity was derived from these lysis times and expressed in units by multiplying their reciprocal by 10,000.…”

Section: Methodsmentioning

confidence: 99%

Fibrinolytic Activity of Shunt Arterial Blood in Patients on Regular Dialysis Treatment

Rastogi¹,

Menon²

1970

J Vasc Res

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When fibrinolytic activity of arterial blood from arteriovenous shunts in patients on regular dialysis treatment was compared with arterial blood of age-matched subjects without renal disease no statistically significant difference was observed. It is suggested that this may be due either to the damaged kidneys continuing to produce plasminogen activator or to the smaller amount of activator produced by the diseased kidneys being compensated by a reduced removal of it in the lungs.

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Fibrinolysis in Citrated and Oxalated Blood

Cited by 19 publications

References 3 publications

Effects of changes in temperature (local and central) on plasma fibrinolytic activity

Effects of changes in temperature (local and central) on plasma fibrinolytic activity

Clinical and Laboratory Double-blind Investigation on Effect of Fibrinolytic Therapy in Patients with Cutaneous Vasculitis

Fibrinolytic Activity of Shunt Arterial Blood in Patients on Regular Dialysis Treatment

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