Fibrinolysis and Thrombosis in Behçet’s Disease

Sobel, Jack D.; Tabori, S; Tatarski, I.

doi:10.1159/000251604

Cited by 14 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diminished fibrinolytic activity has been demonstrated in Behcet's disease and in different clinical types of cutaneous vasculitis by several authors [3,7,8,12,18]. Chajek et al [3] showed an increase of the inhibi tory potential against plasmin as well as against plasminogen activation in the patients' sera.…”

Section: Discussionmentioning

confidence: 98%

Inhibition of the Fibrinolytic System in Behçet’s Disease?

Asbeck¹,

Meyer-Boernecke²,

Loo³

1977

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

Suppression of the fibrinolytic system is a well-known phenomenon in patients with Behçet’s disease. It is generally explained by an increase in the inhibitory potential. In order to prove this theory, the fibrinolytic system was investigated in 5 male patients with severe chronic Behçet’s disease. By the venous occlusion test, a marked suppression of the activatability of the system could be demonstrated (euglobulin lysis time, various fibrin plate assays). Results of analysis of the known inhibitors could not explain the phenomenon: antithrombin III, α₂-macroglobulin, fast-reacting α₂-antiplasmin, C1 inactivator, and the plasmin-antiplasmin complex were normal. The only change was an elevation of α₁-antitrypsin and fibrinogen in 4 patients possibly due to an acute phase reaction. In addition to the possibility of a hitherto unidentified inhibitor, therefore, a decrease in production or in release of vessel wall activators must also be considered in the pathogenesis of this disorder.

show abstract

Section: Discussionmentioning

confidence: 98%

Inhibition of the Fibrinolytic System in Behçet’s Disease?

Asbeck¹,

Meyer-Boernecke²,

Loo³

1977

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

show abstract

“…Although several authors (Kurban & Ryan, 1969;Vaithianathen & Takato, 1968} have found no significant changes in plasma fibritiolytic activity, most authors have found that some patients with a chronic cutaneous vasculitis do have a decreased plasma-fibrinolytic activity (Nilsson, 1967;Cunliffe, 196S;Isacson & Nilsson, 1972a;Parish, 1972;Chajek, Aronowski & Izak, 1973;Sobell, Tabori & Tatarski, 1974)-All our data have been performed on patients who were not overweight, not on drugs and who were fasting; such factors modify plasma-fibrinolytic activity. Fig.…”

mentioning

confidence: 99%

Dowling oration 1975. FIBRINOLYSIS AND VASCULITIS

Cunliffe

1976

Clin Exp Dermatol

View full text Add to dashboard Cite

“…BD is a recurrent multisystem inflammatory disorder characterized by vasculitis and arteritis [ 1 , 2 ] and involves blood vessels of all sizes [ 11 – 13 ]. Conversely, IgAV is defined as vasculitis with IgA1-dominant immune deposits; it affects small vessels, skin, and the gastrointestinal tract and causes arthritis [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Behçet’s disease (BD) is characterized by recurrent oral and genital ulceration, ocular disease, and several systemic manifestations, including skin lesions, gastrointestinal involvement, neurologic disease, vascular disease, and arthritis [ 1 ]. BD can involve blood vessels of all sizes; hence, most of its clinical manifestations are caused by vasculitis [ 2 ]. In 1963, the first occurrence of proteinuria and hematuria was reported in 13 of 65 BD patients [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

A novel case of renal pathergy reaction in a Behçet’s disease patient complicated by IgA vasculitis

et al. 2017

View full text Add to dashboard Cite

BackgroundA pathergy reaction is defined as a hyperreactivity of the skin in response to minimal trauma, which is important in the diagnosis of Behçet’s disease (BD). However, a pathergy reaction may not be restricted to the skin, and little is known about whether an invasive medical procedure can induce the reaction. Here we present a pathergy reaction induced by renal biopsy, an invasive procedure.Case presentationA 46-year-old man who was diagnosed with IgA vasculitis (IgAV) at the age of 38 was treated with prednisolone and mizoribine. However, complications such as common carotid arteritis or recurrent oral ulcer suggested the possibility of another pathophysiology. Later, increasing urine protein developed, suggesting disease aggravation. However, renal biopsy showed arteriosclerotic changes caused mainly by hypertension, negating exacerbation. After renal biopsy, his renal dysfunction and body temperature fluctuated, and detailed examinations revealed recurrent oral and genital ulcers and a folliculitis-like rash on his scrotum. Later, he complained of myodesopsia caused by hemorrhage in the ocular fundus due to occlusive vasculitis. Complete BD was diagnosed after development of the symptoms, and he was treated with prednisolone and colchicine.ConclusionCo-occurrence of BD with IgAV is very rare and may be associated with immune disorders. Interestingly, a renal biopsy revealed BD, which was masked by the presence of IgAV, and elucidated the etiology of the unexplainable symptoms. To the best of our knowledge, this is the first report of renal pathergy. This case enlightens clinicians to the fact that not only a needle stimulation but also an invasive procedure can cause a pathergy reaction.

show abstract

Fibrinolysis and Thrombosis in Behçet’s Disease

Cited by 14 publications

References 9 publications

Inhibition of the Fibrinolytic System in Behçet’s Disease?

Inhibition of the Fibrinolytic System in Behçet’s Disease?

Dowling oration 1975. FIBRINOLYSIS AND VASCULITIS

A novel case of renal pathergy reaction in a Behçet’s disease patient complicated by IgA vasculitis

Contact Info

Product

Resources

About