Fibrinolysis and Thromboplastic Activity in Relation to Hemorrage in Transvesical Prostatectomy

Ladehoff, Aa.; Rasmussen, John C.

doi:10.1080/00365516109137274

Cited by 11 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data presented here, supplemented with previously published data on the distribution of fibrinolytic activity in animal and human organs ( 1,2,18) show that large differences exist in the local balance between fibrin formation and fibrin resolution (6). It is seen that there are several possible combinations, examples of which are shown in Table 2.…”

Section: C2 Czsupporting

confidence: 65%

Assay and Content of Tissue Thromboplastin in Different Organs*

Astrup¹

1965

Thromb Haemost

View full text Add to dashboard Cite

Summary1. The assay of thromboplastin in tissues in terms of units of concentration by means of the double logarithmic graph is described and discussed. The significance of comparing thromboplastin in terms of concentrations and not in terms of activities is explained.2. The concentration of thromboplastin in some human and animal organs is estimated. Great variations are encountered in concentrations. The differences are larger than is generally assumed from activity assays only. The possible role of these differences in the local repair of tissue injuries as part of the hemostatic balance is mentioned.

show abstract

Section: C2 Czsupporting

confidence: 65%

Assay and Content of Tissue Thromboplastin in Different Organs*

Astrup¹

1965

Thromb Haemost

View full text Add to dashboard Cite

show abstract

“…Part of the variation in the results may be due to the fact that cancer originates and develops in the peripheral glandular zone of the prostate, while BPH involves the inner periurethral gland (see McNeal, 1970;Franks, 1977). Ladehoff and Rasmussen (1961) reported quantitative differences in various regions of hyperplastic prostates, and it is not certain if this reflects the degree of vascularization or if tumor itself contains activator (sGe also Astrup, 1966;Kester, 1969;Liedholm and Astedt, 1974;Coune et al, 1979). A study of activator activity in different sections of benign prostate using the methods described in this report is in progress.…”

Section: Discussionmentioning

confidence: 87%

Plasminogen activator content of neoplastic and benign human prostate tissues; fibrin augmentation of an activator activity

Camiolo

Markus

Evers

et al. 1981

Intl Journal of Cancer

View full text Add to dashboard Cite

The plasminogen activator content of the extracts of excise prostate cancers (25 specimens) was determined with an azocasein assay and found to be on the average 1.7 times higher than that of extracts of excised prostate benign hyperplasias (29 specimens). Both groups contained the same average percentage of human urokinase type activator (approximately 45%) as determined by the inhibition of activity when anti-human urokinase antibody was included in the assay system. The two types of activators were partially purified and found to have distinctly different properties. The most striking difference was the large augmentation of activity o the non-urokinase enzyme in fibrinolysis. The implications of an enhanced fibrinolysis relative to azocaseinolysis (or other) is discussed, particularly with respect to its importance in the quantitation and characterization of activators by different investigators. Highly purified urokinase-like activator was found to be similar to commercial urokinase preparation with respect to molecular weight, isoelectric point, inhibition by the antibody, and inhibition by placenta inhibitor.

show abstract

“…In our study (30) a rise of the fibrinolytic activity of the blood was observed immediately after enucleation of the prostate and the level remained increased for several hours, but was normal next day. This may partly explain that 80% of the average total blood loss was found within this time, but besides general fibrinolysis the bleed ing may be influenced by the individually variable local factors as fibrinolytic and thromboplastic tissue activity, especially of the "capsule" , in relation to which the size of the prostatic fossa, that is the amount of removed adenomatous tissue, may play a role.…”

Section: )mentioning

confidence: 75%