Fibrinolysis and Recurrence of Myocardial Infarction

Jespersen, Jørgen; Gram, Jørgen Brodersen; Kostis, J. B.

doi:10.1016/s0140-6736(87)91005-1

The Lancet

1987

DOI: 10.1016/s0140-6736(87)91005-1

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Fibrinolysis and Recurrence of Myocardial Infarction

Jørgen Jespersen

Jørgen Brodersen Gram

J. B. Kostis³

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1989

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Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Reduced endothelial prostacyclin (PGI 2 ) production; 2 2. Increased platelet aggregability and reduced platelet sensitivity to exogenous PGI 2 ; 3 3. reduced fibrinolytic activity, [4][5][6] possibly reflecting an increase of plasminogen activator inhibitor (PAI) concentrations; 7 and 4. increased levels of fibrinopeptide A, expressing an increase of thrombin activity. 8 ' 9 All these changes can modify the course of coronary thrombosis, since it was demonstrated that persistently elevated thrombin activity constitutes a relative obstacle to the recanalizing action of fibrinolytic agents 8 and involves a greater risk of reobstruction.…”

mentioning

confidence: 99%

Use of Defibrotide in the Treatment of Acute Myocardial Infarction

Milazzotto

Carelli²,

Citone³

et al. 1989

Semin Thromb Hemost

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The results of this preliminary clinical trial confirm the thrombolytic effect of defibrotide demonstrated in preclinical models; demonstrate the positive influence of the product on the natural history of early AMI; suggest that the optimal dosage range should include not less than 1.6 gm of defibrotide during the first hour of treatment; and justify further commitment in the study of defibrotide also beyond the scope of treating AMI.

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mentioning

confidence: 99%

Use of Defibrotide in the Treatment of Acute Myocardial Infarction

Milazzotto

Carelli²,

Citone³

et al. 1989

Semin Thromb Hemost

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Fibrinolyse und Blutgerinnung bei ischämischer Herzerkrankung

Jespersen

Munkvad²,

Gram

1991

Hamostaseologie

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ZusammenfassungDieser Bericht gibt einen Überblick über die mit der Entwicklung der ischämischen Herzkrankheit (IH) verbundenen Abweichungen der Hämostase und auch über solche Abweichungen, die für die Entwicklung des akuten ischämischen Herzsyndroms von Bedeutung sein könnten.Es wird gezeigt, daß Abweichungen im t-PA/PAI-1-System auf eine endotheliale Dysfunktion bei Patienten mit IH hinweisen. Es werden 3 Mechanismen vorgestellt, die eine derartige Endothelzelldysfunktion auslösen könnten, d.s. erhöhte Insulinproduktion, erhöhte Produktion von Entzündungsmediatoren und erhöhte Thrombinproduktion.Schließlich wird die enge Beziehung zwischen Gerinnung und Fibrinolyse bei Patienten mit IH diskutiert. Die besprochenen experimentellen und klinischen Studien liefern gute Beweise dafür, daß die Reaktionen von t-PA und PAI-1 in den Endothelzellen miteinander verbunden sind und daß eine enge Beziehung zwischen der Bildung von Thrombin und der Produktion bzw. Freisetzung von t-PA und PAI-1 mit der Endotheizellfunktion bei Patienten mit IH besteht..

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Fibrinolysis and Recurrence of Myocardial Infarction

Cited by 2 publications

References 12 publications

Use of Defibrotide in the Treatment of Acute Myocardial Infarction

Use of Defibrotide in the Treatment of Acute Myocardial Infarction

Fibrinolyse und Blutgerinnung bei ischämischer Herzerkrankung

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