Fibrinolysis: A possible factor in the control of postoperative hemorrhage in the patient with hemophilia

Bump, Robert L.; Kolodny, Scott

doi:10.1016/0030-4220(73)90237-5

Cited by 18 publications

(1 citation statement)

References 25 publications

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“…Due to the increased risk of postoperative bleeding or oral hematoma in patients on anticoagulant therapy, performing surgical procedures in such patients becomes a significant concern for a dentist [ 7 ]. According to a study by Bump et al, fear of hemorrhages may elevate stress levels in cardiac patients, which may induce fibrinolytic activity [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Direct Oral Anticoagulant Therapy (DOACs) on oral surgical procedures: a systematic review

Darwish

2023

BMC Oral Health

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Background Direct oral anticoagulants (DOACs) were developed to overcome the drawbacks of oral anticoagulants. However, not much has been discussed about the perioperative management of patients on DOACs during oral surgical procedures. Thus, we aim to determine the risk of perioperative and postoperative bleeding during oral surgical procedures in patients on DOACs. Methods A detailed literature search was performed to find potentially relevant studies using the Cochrane Library, Clinical Key, ClinicalTrials.gov, Google Scholar, Ovid, ScienceDirect, and Scopus. Every article available for free in English literature for the past 10 years, between 2012 and 2022, was searched. Results A total of 2792 abstracts were selected through a search strategy across various search engines. Based on inclusion and exclusion criteria, eleven clinical studies using DOACs as anticoagulants or studies comparing patients with and without DOACs under oral surgery procedures were found. The results were inconsistent and varied, with a few studies recommending DOAC administration with the bare minimum reported complications and others finding no statistically significant difference between discontinuation or continuation of drugs, especially across basic dental procedures. Conclusion Within the limitations of the study, it can be concluded that minor oral surgical procedures are safe for patients on DOAC therapy. However, the continuation or discontinuation of DOACs in patients undergoing oral surgical procedures remains controversial and requires further studies to extrapolate the results.

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Section: Introductionmentioning

confidence: 99%

The Effect of Direct Oral Anticoagulant Therapy (DOACs) on oral surgical procedures: a systematic review

Darwish

2023

BMC Oral Health

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Prostatectomy in an 85-Year-Old Hemophiliac

Wylin¹,

Schneider²

1976

Arch Surg

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Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions

Galen

Engelen

Mauser‐Bunschoten

et al. 2015

Cochrane Database of Systematic Reviews

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Despite the discovery of a beneficial effect of systemically administered tranexamic acid and epsilon aminocaproic acid in preventing postoperative bleeding in people with haemophilia undergoing dental extraction, the limited number of randomised controlled trials identified, in combination with the small sample sizes and heterogeneity regarding standard therapy and treatment regimens between the two trials, do not allow us to conclude definite efficacy of antifibrinolytic therapy in oral or dental procedures in people with haemophilia. No trials were identified in people with Von Willebrand disease.

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Fibrinolysis: A possible factor in the control of postoperative hemorrhage in the patient with hemophilia

Cited by 18 publications

References 25 publications

The Effect of Direct Oral Anticoagulant Therapy (DOACs) on oral surgical procedures: a systematic review

The Effect of Direct Oral Anticoagulant Therapy (DOACs) on oral surgical procedures: a systematic review

Prostatectomy in an 85-Year-Old Hemophiliac

Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions

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