Fibrinogen, inflammation and concentric left ventricular hypertrophy in chronic renal failure

Zoccali, Carmine; Benedetto, Frank; Mallamaci, Francesca; Tripepi, Giovanni; Cutrupi, Sebastiano; Parlongo, Saverio; Malatino, Lorenzo; Bonanno, Graziella; Rapisarda, Francesco; Fatuzzo, Pasquale; Seminara, Giuseppe; Nicocia, Giacomo; Buemi, Michele

doi:10.1046/j.1365-2362.2003.01169.x

Cited by 54 publications

(59 citation statements)

References 28 publications

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“…This is the first report demonstrating that plasma adiponectin levels predict progression of coronary atherosclerosis in both a T1DM and non-DM population, adding significantly to pre- vious limited evidence for an inverse relationship between circulating adiponectin levels and CAD. 2,15,16 In addition, a recent nested case-control study from the Health Professionals Follow-up Study reported that in men 40 to 75 years of age, high adiponectin levels were associated with a lower risk of myocardial infarction. 17 The use of CAC as a marker of CAD rather than traditional end points such as coronary artery stenosis, myocardial infarction, or death is one of the limitations of our study.…”

Section: Discussionmentioning

confidence: 99%

“…2,12,[15][16][17] Proposed mechanisms by which adiponectin exerts protective effects include suppression of tumor necrosis factor-␣-induced endothelial adhesion molecule expression, macrophage-to-foam cell transformation, and tumor necrosis factor-␣ expression in macrophage tissue. 9,12,27 Further clinical and mechanistic studies of adiponectin in relationship to CAD are needed.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, adiponectin has been shown to be lower in patients with advanced coronary artery disease (CAD) than in age-, gender-, and BMI-matched controls. 12 Prospective data demonstrating that adiponectin levels are significantly and independently related to development of atherosclerosis or CAD 12,15 have been reported in patients with end-stage renal disease (ESRD) 16 and in a nested case-control study within the Health Professionals Follow-up Study. 17 In contrast to a significant body of evidence linking low adiponectin to insulin resistance and T2DM, little is known about adiponectin levels in type 1 diabetes (T1DM), which is usually not characterized by insulin resistance.…”

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confidence: 99%

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Low Plasma Adiponectin Levels Predict Progression of Coronary Artery Calcification

et al. 2005

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Background-Circulating adiponectin levels are lower in men than in women and lower in advanced coronary artery disease, obesity, and type 2 but not type 1 diabetes. However, it is not known whether low adiponectin levels predict development of atherosclerosis independently of other cardiovascular risk factors. Methods and Results-Progression of coronary artery calcification (CAC) over an average of 2.6 years (range, 1.6 to 3.3)was assessed in a cohort of patients with type 1 diabetes and nondiabetic subjects 19 to 59 years of age. In this nested case-control substudy, plasma adiponectin levels were measured in 101 cases with significant CAC progression and in 205 controls. Controls were oversampled on the basis of age, gender, diabetes status, and presence of baseline CAC. In conditional logistic regression adjusted for baseline CAC volume and other significant predictors of CAC progression, adiponectin levels were inversely related to progression of CAC in diabetic (OR, 0.47; 95% CI, 0.24 to 0.94) and nondiabetic (OR, 0.15; 95% CI, 0.05 to 0.40 for a doubling in adiponectin levels) subjects. Adjustment for additional cardiovascular risk factors did not change this association. In conditional logistic regression models by quartiles of plasma adiponectin levels, the probability value for trend was statistically significant for all participants (PϽ0.001) and nondiabetic participants (PϽ0.001) and was borderline for type 1 diabetics (Pϭ0.08). Conclusions-Low

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Low Plasma Adiponectin Levels Predict Progression of Coronary Artery Calcification

et al. 2005

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“…In these studies, inflammation was determined to be present in a particular participant if serum level of an inflammatory biomarker exceeded its median value for the whole cohort. We computed a composite score ranging from 0 to 5 based on levels of the following biomarkers and the value at or above which a score of 1 was assigned hs-CRP .3 mg/L (21), fibrinogen .350 mg/dl (22), IL-6 $6 pg/ml (23), TNF-a $7 pg/ml, and IL-1b $0.39 pg/ml (23,24). The cut-off values for individual biomarkers were chosen from published literature.…”

Section: Calculation Of Inflammation Scorementioning

confidence: 99%

Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC

Gupta

Mitra

Kanetsky

et al. 2012

Clinical Journal of the American Society of Nephrology

433

344

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“…ref. 88,[366][367][368][369][370][371][372][373][374][375][376], and fibrin clot properties also vary in this way with various diseases (e.g. ref.…”

Section: Effects Of Fibrinogen Concentration On the Nature Of The Clotmentioning

confidence: 99%

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

Kell

Pretorius

2014

Integrative Biology

127

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Although the two phenomena are usually studied separately, we summarise a considerable body of literature to the effect that a great many diseases involve (or are accompanied by) both an increased tendency for blood to clot (hypercoagulability) and the resistance of the clots so formed (hypofibrinolysis) to the typical, 'healthy' or physiological lysis. We concentrate here on the terminal stages of fibrin formation from fibrinogen, as catalysed by thrombin. Hypercoagulability goes hand in hand with inflammation, and is strongly influenced by the fibrinogen concentration (and vice versa); this can be mediated via interleukin-6. Poorly liganded iron is a significant feature of inflammatory diseases, and hypofibrinolysis may change as a result of changes in the structure and morphology of the clot, which may be mimicked in vitro, and may be caused in vivo, by the presence of unliganded iron interacting with fibrin(ogen) during clot formation. Many of these phenomena are probably caused by electrostatic changes in the iron-fibrinogen system, though hydroxyl radical (OH ) formation can also contribute under both acute and (more especially) chronic conditions. Many substances are known to affect the nature of fibrin polymerised from fibrinogen, such that this might be seen as a kind of bellwether for human or plasma health. Overall, our analysis demonstrates the commonalities underpinning a variety of pathologies as seen in both hypercoagulability and hypofibrinolysis, and offers opportunities for both diagnostics and therapies.

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Fibrinogen, inflammation and concentric left ventricular hypertrophy in chronic renal failure

Abstract: Elevated fibrinogen is independently associated with LV concentric hypertrophy and systolic dysfunction in ESRD patients. These relationships may contribute to the negative prognostic impact of elevated fibrinogen levels in ESRD.

Cited by 54 publications

References 28 publications

Low Plasma Adiponectin Levels Predict Progression of Coronary Artery Calcification

Low Plasma Adiponectin Levels Predict Progression of Coronary Artery Calcification

Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

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