Fibrinogen, fibrin degradation products and risk of sarcopenia

Chen, Jinliang; Chen, Dongmei; Luo, Can; Sun, Yue; Zhao, Yutong; Huang, Changquan; Zhao, Kun; Xiao, Qian

doi:10.1016/j.clnu.2021.06.031

Cited by 9 publications

(3 citation statements)

References 41 publications

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“…Some studies have focused on the relationship between serum coagulation factor levels and sarcopenia. Chen et al reported that the fibrinogen levels were higher in patients with sarcopenia because of the high inflammatory conditions (25). This finding was not directly related to our results; however, sarcopenia may influence the coagulation pathway and systemic inflammation.…”

Section: Discussioncontrasting

confidence: 67%

Influence of sarcopenia on postoperative complications in patients undergoing autologous microsurgical breast reconstruction: an inverse probability of treatment weighting analysis

Lee,

Yang,

Lee

et al. 2023

Front. Oncol.

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BackgroundSarcopenia is characterized by the loss of skeletal muscle mass and power. Preoperative sarcopenia may be associated with an increased risk of postoperative complications after autologous free-flap breast reconstruction surgery; however, this relationship is controversial.ObjectivesThis study aimed to determine whether preoperative sarcopenia is associated with a high complication rate in patients undergoing autologous free-flap breast reconstruction.MethodsPatients who underwent autologous free-flap breast reconstruction at our hospital between 2019 and 2021 were included in the study. Data on significant complications requiring surgical intervention were retrospectively collected from the medical records. Sarcopenia was defined as having a skeletal muscle index value <41 cm2/m2. The skeletal muscle index was calculated by dividing the sum of the psoas and iliopsoas muscle areas at the level of the third lumbar vertebra by the patient’s height in meters squared. The relationship between preoperative sarcopenia and postoperative complications was investigated using an inverse probability of treatment weighting (IPTW) analysis.ResultsAmong the 203 participants, 90 (44.33%) had preoperative sarcopenia. The general patient characteristics were similar between the sarcopenia and non-sarcopenia groups after IPTW adjustment. Sarcopenia did not significantly increase the risk of flap failure or emergency surgery related to breast reconstruction before IPTW adjustment. However, after IPTW adjustment, the rates of recipient site infection and hematoma were significantly higher in participants with sarcopenia than in those without sarcopenia (p < 0.001 and p = 0.014, respectively).ConclusionPreoperative sarcopenia may influence certain complications of autologous free-flap breast reconstruction surgery.

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Section: Discussioncontrasting

confidence: 67%

Influence of sarcopenia on postoperative complications in patients undergoing autologous microsurgical breast reconstruction: an inverse probability of treatment weighting analysis

Lee,

Yang,

Lee

et al. 2023

Front. Oncol.

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“…While in our cohort women and men did not differ in their BMI, they could still differ in their adiposity patterns: higher visceral adiposity, more common in women than men, is known to be highly related to decreased gait speed 40 . In cohorts of older adults, who show elevated serum inflammatory markers, including CRP and fibrinogen, compared to middle aged adults, both markers were associated with decreased gait both in males and females 10 , 12 , 41 – 43 . This dynamic could suggest that the inflammatory stress induced by CRP and fibrinogen is significant only above a certain basal level, and that this threshold could vary between males and females, causing an earlier reaction among females.…”

Section: Discussionmentioning

confidence: 94%

CRP, but not fibrinogen, is associated with gait speed as early as middle age, in females but not males

Ahmed-Yousef,

Dilian,

Iktilat

et al. 2023

Sci Rep

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Low grade systemic inflammation and age-related gait speed decline are known to be related in older adults, but their relations in the early stages of the aging process are yet to be fully described. The aim of this study was to examine the relationship between gait speed and two inflammation markers—c-reactive protein (CRP) and fibrinogen—in a cohort of middle-aged adults in Israel. 326 healthy, middle-aged, Muslim-Arabs from three villages in northern Israel participated in this cross-sectional study. Serum CRP and fibrinogen were measured via blood tests, and gait speed was assessed with the 6-min walk test (6MWT). After adjusting for sex, age, height, BMI, systolic blood pressure, fasting blood glucose and triglycerides, executive function, smoking status and aerobic physical activity, gait speed was negatively and significantly associated with CRP (b = − 0.01, p = 0.029). When stratifying by gender, this link remained significant only among females (b = − 0.012, p = 0.041), such as that an increase of one SD unit of CRP was associated with a 0.047 m/s decrease in gait speed. No significant link was found between fibrinogen levels and gait speed. Blood CRP levels are associated with a slower walking speed already in middle age, independent of age, executive function and cardio-metabolic factors, among female Arab-Muslims in Israel. Future studies should examine this relationship longitudinally and investigate a broader array of inflammation markers. Systemic inflammation may serve as an early marker for people at risk of decreased walking or accelerated aging; Early identification and intervention among at-risk individuals may help prevent or slow gait speed decline, and promote healthier aging.

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“…Frail and pre-frail individuals in the Cardiovascular Health Study exhibited significantly higher fibrinogen levels than controls [140]. Elevated fibrinogen levels are longitudinally associated with frailty, slow gait speed, and low muscle strength [107,141,142]. Further, higher peripheral fibrinogen levels are associated with CI risk and severity [143,144].…”

Section: Fibrinogenmentioning

confidence: 98%

Inflammatory Markers Associated with Physical Frailty and Cognitive Impairment

2024

Aging dis

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In older adults, physical frailty and cognitive impairment contribute to adverse outcomes. However, the research on mechanisms underlying physical frailty and cognitive impairment is limited. Low-grade chronic inflammation is a characteristic of aging. Particularly, an imbalance in pro-and anti-inflammatory mechanisms may be involved in frailty and neurodegenerative disorders. Therefore, exploring the inflammatory markers of physical frailty and cognitive impairment is crucial to fully understanding these mechanisms and establishing a substantial link between these two disorders. Notably, few studies have focused on exploring inflammatory markers in both physical frailty and cognitive impairment, posing a major challenge in elucidating the link between them. Therefore, substantial efforts are required for the better prevention of physical frailty and cognitive impairment. In this review, we explored the role of inflammatory markers as a potential link between frailty and cognitive impairment.

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Fibrinogen, fibrin degradation products and risk of sarcopenia

Cited by 9 publications

References 41 publications

Influence of sarcopenia on postoperative complications in patients undergoing autologous microsurgical breast reconstruction: an inverse probability of treatment weighting analysis

Influence of sarcopenia on postoperative complications in patients undergoing autologous microsurgical breast reconstruction: an inverse probability of treatment weighting analysis

CRP, but not fibrinogen, is associated with gait speed as early as middle age, in females but not males

Inflammatory Markers Associated with Physical Frailty and Cognitive Impairment

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