Fibrinogen depletion coagulopathy predicts major bleeding after thrombolysis for ischemic stroke: A multicentre prospective study

Romoli, Michele; Vandelli, Laura; Bigliardi, Guido; Naccarato, Marcello; Balestrino, Maurizio; Moller, Jessica; Musolino, Rosa Fortunata; Gentile, Mauro; Forlivesi, Stefano; Dell’Acqua, Maria Luisa; Rosafio, Francesca; Maffei, Stefania; Migliaccio, Ludovica; Trenti, Tommaso; Mancini, Rita; Manganotti, Paolo; Melis, Maurizio; Zini, Andrea

doi:10.1016/j.jns.2021.117662

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, recent studies have shown that vascular abnormalities, including microaneurysms, exist in the brain tissue surrounding the hematoma and are likely to play a role in the pathogenesis of HE (36,37). Moreover, studies have also suggested that coagulation abnormalities and inflammation may contribute to the development of HE (38,39). Furthermore, the activation of the inflammatory cascade, generation of coagulation end-products, and hemoglobin degradation products lead to the initiation of a secondary injury cascade, which proceeds via diverse molecular pathways, The etiology of hematoma expansion in intracerebral hemorrhage (by Figdraw).…”

Section: Pathophysiologymentioning

confidence: 99%

Research advances in imaging markers for predicting hematoma expansion in intracerebral hemorrhage: a narrative review

Huang

2023

Front. Neurol.

View full text Add to dashboard Cite

IntroductionStroke is a major global health concern and is ranked as the second leading cause of death worldwide, with the third highest incidence of disability. Intracerebral hemorrhage (ICH) is a devastating form of stroke that is responsible for a significant proportion of stroke-related morbidity and mortality worldwide. Hematoma expansion (HE), which occurs in up to one-third of ICH patients, is a strong predictor of poor prognosis and can be potentially preventable if high-risk patients are identified early. In this review, we provide a comprehensive summary of previous research in this area and highlight the potential use of imaging markers for future research studies.Recent advancesImaging markers have been developed in recent years to aid in the early detection of HE and guide clinical decision-making. These markers have been found to be effective in predicting HE in ICH patients and include specific manifestations on Computed Tomography (CT) and CT Angiography (CTA), such as the spot sign, leakage sign, spot-tail sign, island sign, satellite sign, iodine sign, blend sign, swirl sign, black hole sign, and hypodensities. The use of imaging markers holds great promise for improving the management and outcomes of ICH patients.ConclusionThe management of ICH presents a significant challenge, and identifying high-risk patients for HE is crucial to improving outcomes. The use of imaging markers for HE prediction can aid in the rapid identification of such patients and may serve as potential targets for anti-HE therapies in the acute phase of ICH. Therefore, further research is needed to establish the reliability and validity of these markers in identifying high-risk patients and guiding appropriate treatment decisions.

show abstract

Section: Pathophysiologymentioning

confidence: 99%

Research advances in imaging markers for predicting hematoma expansion in intracerebral hemorrhage: a narrative review

Huang

2023

Front. Neurol.

View full text Add to dashboard Cite

show abstract

The Change in Fibrinogen is Associated with Outcome in Patients with Acute Ischemic Stroke Treated with Endovascular Thrombectomy

Wang

Cui

et al. 2023

Neurocrit Care

View full text Add to dashboard Cite

Fibrinogen depletion coagulopathy predicts major bleeding after thrombolysis for ischemic stroke: A multicentre prospective study

Cited by 2 publications

References 0 publications

Research advances in imaging markers for predicting hematoma expansion in intracerebral hemorrhage: a narrative review

Research advances in imaging markers for predicting hematoma expansion in intracerebral hemorrhage: a narrative review

The Change in Fibrinogen is Associated with Outcome in Patients with Acute Ischemic Stroke Treated with Endovascular Thrombectomy

Contact Info

Product

Resources

About