Fibrinogen Degradation Products and Periodontitis: Deciphering the Connection

Dikshit, Shweta

doi:10.7860/jcdr/2015/14729.6922

Cited by 11 publications

(10 citation statements)

References 22 publications

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“…For the severe cases, in which a persistent inflammatory status appears to act as a trigger for the coagulation cascade and is associated with increased levels of fibrinogen degradation products (e.g., D‐dimer) (Cao & Li, 2020), we believe that prior underlying untreated moderate or severe periodontitis may worsen COVID‐19. Conversely, periodontal therapy in individuals with initial COVID‐19 symptoms may reduce the risk of the condition to become severe by reducing the amount of D‐dimer in the plasma, which is what we see when patients with periodontitis are treated (Dikshit, 2015).…”

mentioning

confidence: 95%

Oral manifestations in coronavirus disease 2019 (COVID‐19)

Vieira

2020

Oral Diseases

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confidence: 95%

Oral manifestations in coronavirus disease 2019 (COVID‐19)

Vieira

2020

Oral Diseases

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“… 2 , 8 SARS-CoV-2 may also alter taste bud sensitivity. 9 Therefore, COVID-19 could contribute to several oral signs and symptoms, such as taste loss, nonspecific ulcers, blisters, desquamative gingivitis, and co-infections with fungal infections such as candida, 10 , 11 and few studies have been published regarding oral manifestations in specific. 12–14 However, it is still controversial whether these symptoms/signs are specific to COVID-19 disease as a result of the SARS-CoV-2 infection or as a result of other underlying conditions and consequences, such as co-infections, immune system impairment caused by the virus, or adverse effects of COVID-19 medications.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Oral Manifestations in Symptomatic Non-Hospitalized COVID-19 Patients: A Cross-Sectional Study on a Sample of the Saudi Population

Natto¹,

Afeef²,

Khalil³

et al. 2021

IJGM

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Purpose Few case reports and letters to the editor have been published regarding oral signs and symptoms in COVID-19 patients. The aim of the study therefore is to investigate different types of oral manifestations in COVID-19 patients as well as their prevalence. Patients and Methods The study is a cross-sectional study from a single medical center. A convenience sample was taken from all patients who were COVID-19 confirmed, symptomatic, and non-hospitalized. Demographic information, medical and travel history, general symptoms, and clinical examination results of the oral cavity were collected. Results This study included a total of 109 patients. Loss of taste was the most common oral manifestation of COVID-19 (43.4%), followed by erythema/desquamated gingivitis and coated tongue (7.3% each) and ulcers/blisters (6.4%). Loss of taste was the only symptom persisting for 10 days. Oral manifestations appeared as a single symptom (79.3%), and dorsum of tongue was the most common oral location (72.4%). Conclusion Loss of taste was the most prevalent specific reported oral manifestation. Other nonspecific oral lesions/symptoms are controversial. It has been suggested that oral examinations of COVID-19 patients should be conducted as part of routine examinations to investigate any possible correlation between the disease and the oral cavity.

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“…60,61 Fibrinogen is converted into fibrin and cleaved by plasmin yielding products such as D-dimer. 62 An important relationship exists between the fibrinolytic system and the RAA system. In fact, binding of COVID-19 to ACE2 prevents degradation of angiotensin 2 leading to excess and causing plasminogen activator inhibitor (PAI-1) which acts as the main inhibitor of fibrinolysis.…”

Section: Discussionmentioning

confidence: 99%

Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders

Alam

2021

SAGE Open Medicine

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Severe acute respiratory syndrome coronavirus-2 has emerged as a new viral pandemic, causing Coronavirus disease 2019 (COVID-19) leading to a wide array of symptoms ranging from asymptomatic to severe respiratory failure. However, coagulation disorders have been found in some patients infected with SARS-CoV-2, leading to either a clotting disorder or hemorrhage. Several mechanisms attempt to explain the mechanism behind the pro-coagulant state seen with COVID-19 patients, including different receptor binding, cytokine storm, and direct viral endothelial damage. SARS-CoV-2 has also been recently found to bind to CLEC4M receptor, a receptor that participates in the clearance of von Willebrand Factor and Factor VIII. The competitive binding of SARS-CoV-2 to CLEC4M could lead to decreased clearance, and therefore a promotion of a pro-coagulative state; however, an experimental study needs to be done to prove such an association.

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Fibrinogen Degradation Products and Periodontitis: Deciphering the Connection

Cited by 11 publications

References 22 publications

Oral manifestations in coronavirus disease 2019 (COVID‐19)

Oral manifestations in coronavirus disease 2019 (COVID‐19)

Characteristics of Oral Manifestations in Symptomatic Non-Hospitalized COVID-19 Patients: A Cross-Sectional Study on a Sample of the Saudi Population

Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders

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