Fibrinogen and fibrin: synthesis, structure, and function in health and disease

Wolberg, Alisa S.

doi:10.1016/j.jtha.2023.08.014

Cited by 20 publications

(11 citation statements)

References 57 publications

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“…FG can inhibit the generation of peroxides [ 36 ], synergizing with PEV to exert antioxidative effects within the intervertebral disc, thereby promoting disc repair. Additionally, FG can interact with various plasma proteins and cells to withstand biochemical and biomechanical disruptions, facilitating wound healing [ 37 ]. Firstly, FG@PEV effectively reinstates the equilibrium between ECM synthesis and catabolism by suppressing the inflammatory microenvironment within the medulla oblongata.…”

Section: Discussionmentioning

confidence: 99%

A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis

Wang,

Zhang,

et al. 2024

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis

Wang,

Zhang,

et al. 2024

Materials Today Bio

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“…Moreover, Fg deposition has been observed in the tumor extracellular matrix ( 5 ) and the walls of angiogenic blood vessels ( 6 ), implying associations between Fg and tumor angiogenesis and metastasis. These interactions are mediated by binding sites on Fg, which engage with diverse molecules, including various plasma proteins and cellular receptors ( 7 ). Furthermore, multiple pathways have been identified linking Fg to tumor progression ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen and tumors

Wu,

Yu,

Chen

et al. 2024

Front. Oncol.

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Elevated plasma fibrinogen (Fg) levels consistently correlate with an unfavorable prognosis in various tumor patient cohorts. Within the tumor microenvironment, aberrant deposition and expression of Fg have been consistently observed, interacting with multiple cellular receptors and thereby accentuating its role as a regulator of inflammatory processes. Specifically, Fg serves to stimulate and recruit immune cells and pro-inflammatory cytokines, thereby contributing to the promotion of tumor progression. Additionally, Fg and its fragments exhibit dichotomous effects on tumor angiogenesis. Notably, Fg also facilitates tumor migration through both platelet-dependent and platelet-independent mechanisms. Recent studies have illuminated several tumor-related signaling pathways influenced by Fg. This review provides a comprehensive summary of the intricate involvement of Fg in tumor biology, elucidating its multifaceted role and the underlying mechanisms.

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“…Human fibrinogen is a dimeric glycoprotein with a molecular weight of approximately 340 kDa ( 1 ), which consists of two identical halves synthesised exclusively by the liver. The conversion of soluble fibrinogen into insoluble fibrin is catalysed by thrombin, and it plays a pivotal role in clot formation and stabilisation.…”

Section: Introductionmentioning

confidence: 99%

Severe haemorrhagic diathesis due to acquired hypofibrinogenemia in a patient with early T-cell precursor acute lymphoblastic leukaemia/lymphoma: a case report

Spiezia,

Riva,

Gurrieri

et al. 2024

Front. Cardiovasc. Med.

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The most frequent haematological malignancy associated with acquired hypo/dysfibrinogenemia is multiple myeloma. We present an unusual case of severe haemorrhagic diathesis due to acquired hypofibrinogenemia in a patient with early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL). A 57-year-old male was admitted to the General Internal Medicine Department of Padova University Hospital for acute massive haematomas of the left lower extremity associated with macrohaematuria. Coagulation tests showed prolonged prothrombin time, activated partial thromboplastin time and thrombin time due to isolated severe hypofibrinogenemia (antigen 0.70 g/L and activity 26%). The radiological workup showed a bulky lesion located in the anterior mediastinum, and a biopsy led to the diagnosis of ETP-ALL/LBL. Fibrinogen replacement therapy failed to correct the bleeding diathesis and we were able to exclude other frequent causes of acquired hypofibrinogenemia (i.e., liver dysfunction, fibrinogen-specific antibody or drug toxicity); therefore, we hypothesised that hypofibrinogenemia might stem either from enhanced removal of fibrinogen from the circulation or consumptive coagulopathy. Notably, only after initiating a specific chemotherapy treatment did the patient start showing improvement in bleeding symptoms and achieve normal fibrinogen levels.

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Fibrinogen and fibrin: synthesis, structure, and function in health and disease

Cited by 20 publications

References 57 publications

A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis

A natural hydrogel complex improves intervertebral disc degeneration by correcting fatty acid metabolism and inhibiting nucleus pulposus cell pyroptosis

Fibrinogen and tumors

Severe haemorrhagic diathesis due to acquired hypofibrinogenemia in a patient with early T-cell precursor acute lymphoblastic leukaemia/lymphoma: a case report

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