Fibrinogen and fibrin degradation products in patients undergoing open-heart surgery

Rifón, J.; Fernández, J; Ja, Páramo; Cuesta, B; Rocha, Eduardo

doi:10.1097/00001721-199010000-00027

Cited by 5 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated fibrinogen levels, up to 14 days postoperatively, were ascertained in several studies. 16,33,34 Fibrinogen, and α 1 -proteinase inhibitor levels were significantly higher in the CABG group even before surgery. This may be explained by a pre-existing inflammatory state in patients with coronary artery sclerosis.…”

Section: Discussionmentioning

confidence: 87%

Acute phase and opsonin response in cardiac surgery patients: influence of underlying cardiac disease

Welters¹,

Menges

Ballesteros

et al. 1998

Perfusion

View full text Add to dashboard Cite

Cardiopulmonary bypass (CPB) leads to an activation of plasma cascade systems, complement activation, and an acute phase response. To evaluate the influence of the underlying cardiac disease on the activation pattern of these systems, we compared inflammatory changes in coronary artery bypass grafting (CABG) patients with patients undergoing aortic valve replacement. We investigated changes of the acute phase proteins alpha 1-proteinase inhibitor and fibrinogen, the unspecific opsonin fibronectin, and the complement components C3c and C4 induced by extracorporeal circulation in 12 patients undergoing aortic valve replacement and in 12 patients undergoing CABG. Concentrations of C3c and C4 decreased in both groups after the onset of CPB and C4 concentration remained below post-induction levels up to 24 h after onset of CPB (p = 0.04). Fibronectin levels dropped immediately before the onset of CPB (p = 0.01), reaching the lowest values after 20 min of extracorporeal circulation. Fibrinogen and alpha 1-proteinase inhibitor levels after induction of anaesthesia were significantly higher in the CABG group and remained higher throughout the entire study period (p < 0.001). As an indicator of a postoperative acute phase response, concentrations of both proteins rose in the postoperative period above post-induction levels (p < 0.02).

show abstract

Section: Discussionmentioning

confidence: 87%